AgeCurve

AgeCurve is a biotech company that uses cell lineage trees to unlock predictive power somatic mutations. Its approach, Cell Tree Rings, detects somatic mutations using single-cell RNA sequencing (scRNAseq) from hundreds of cells and constructs a cell lineage tree whose shape correlates with chronological age. In addition to providing a biological age, Cell Tree Rings unveils a temporal history of the aging process, revealing how clonal structure evolves over a lifespan. This platform complements existing aging clocks and may help reduce the current uncertainty in the assessment of geroprotective trials.

The company is working with the Healthy Longevity Clinic to turn its initial results into clinically useful and actionable insights through analysis of the actual underlying somatic mutations in the top cancer driver genes.

Cell Tree Rings have a broad range of applications, including clonal hematopoiesis of indeterminate potential (CHIP) studies, cancer drug efficacy testing, and cell therapies.

Funding and financials

In 2020 AgeCurve raised an undisclosed amount of pre-seed funding from Longevity Tech.fund.