Safeguard Scientifics, Inc. (NYSE: SFE) has a distinguished track record of fostering innovation and building market leaders. For more than 60 years, Safeguard has been providing growth capital and operational support to entrepreneurs across an evolving spectrum of industries. Today, Safeguard is focused specifically on healthcare and technology. Safeguard is a proven partner for entrepreneurs looking to accelerate growth and build long-term value in their businesses. Investors in NYSE:SFE have a unique opportunity to tap into the high potential of Safeguard's early- and growth-stage partners companies.

Safeguard Scientifics

MentorTech Ventures is a seed- and early-stage venture capital fund that invests in companies from the University of Pennsylvania ecosystem. These companies typically have key founders or managers who are students, faculty members or alumni of the university. Sometimes, the companies are based on intellectual property that originated at Penn.

MentorTech Ventures

ARC Angel Fund invests in seed and early-stage companies with high growth potential. We focus primarily on Software, IT, Internet, Tech-Enabled Services, Business Services, Digital Media, Mobile, Healthcare IT, among others. The Fund has a primary focus towards NYC and the surrounding North-East and Mid-Atlantic area companies. ARC Angel Fund invests in industries with which its members have experience, with investments averaging $50,000 to $150,000, each, over the life of the investment.  ARC Angel Fund is a member-led Angel Fund. An Angel Fund is, in essence, a hybrid model between an Angel Group and a Venture Fund. The members of ARC Angel Fund range from experienced Angel Investors and Partners in VC Funds, to executives of successful companies.  Their members bring their own expertise to the table and can actively participate as much as they like in the Fund's investment decisions.

ARC Angel Fund

Merck Global Health Innovation Fund (Merck GHI) is evolving corporate healthcare venture capital globally by utilizing their healthcare ecosystem strategy.  This investment strategy connects innovative companies with complementary technologies to develop integrated healthcare solutions.  Merck GHI has $500M under management and provides growth capital to emerging healthcare technology companies worldwide while leveraging the vast R&D-based, global resources of Merck.  With a vision that data will be the currency in healthcare, GHI invests broadly in digital health.  GHI invests in platform companies with proven technologies or business models where Merck's expertise and perspectives can accelerate revenue growth and enhance value creation.   Since late 2010, Merck GHI has made over 20 investments in Digital Health companies.

Merck Global Health Innovation Fund

CIGNA Corporation operates as a health service company in the United States. It helps to improve the health, well-being, and peace of mind of those it serves by making health care simple, affordable, and predictable.

Cigna

At Guardian, they know that promises matter. They’ve been keeping theirs for over 150 years. They’ve maintained their financial strength for more than a century and a half, despite the countless ups and downs of the economy, so they can meet their future obligations to the people and businesses that put their trust in us. See how their strength, vision, and values make Guardian a company you can rely on.

Guardian Life

Maywic Select Investments is an early stage and growth stage investor in consumer products and retail that promote healthy lifestyles, wellness, and wellbeing.  Founded by Fred Mayerson and Chad Wick, the firm is headquartered in Cincinnati, Ohio.

Maywic Select Investments

Hermed Capital is a Hong Kong-based financial services company that offers related advisory services.

Hermed Capital

HV will act as an instrument of strategic growth in broadening Hikma’s offerings; it will allow Hikma to tap into opportunities in the growing digital health space.HV will invest in companies where Hikma's expertise can accelerate revenue growth and enhance value creation by providing ventures with access to the resources of a multinational pharmaceutical company.We will invest in companies at all stages of development, including start-ups, spinouts, and consortia investments.Our initial investment size is up to $5 million per round. HV will look at global opportunities but with a focus on the US and the Middle East & Africa (MEA). We seek to actively partner with the management teams of portfolio companies to realize the potential of their products and technologies.

Hikma Ventures

Prognos Health

Prognos Health is a health tech company that is pushing the boundaries of healthcare analytics. The company’s platform, prognosFACTOR, has the power to query billions of lab and health records on more than 325 million de-identified patients to answer clinically-focused healthcare questions in minutes, not months. The platform enables the querying and purchasing of patient-centric, HIPAA-Compliant healthcare data from the Prognos Marketplace to address diverse applications, including cohort design, patient journey studies, health outcomes, and more. Customers include 25 of the top 30 pharmaceutical manufacturers and three of the top five payers.

Prognos Health is a leading healthcare data and analytics company that provides a cloud-based software platform and real-world data (RWD) marketplace. The company's platform, Prognos Factor, enables pharmaceutical companies, providers, and payers to access and analyze a vast repository of medical data, including over 30 billion lab records and 325 million de-identified patient records as of October 2022. This comprehensive dataset allows users to pinpoint insights, design patient cohorts, and map patient journeys with unprecedented speed and accuracy.

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Hospital Management

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Prognos Health is a leading healthcare data and analytics company that provides a cloud-based software platform and real-world data (RWD) marketplace. The company's platform, Prognos Factor, enables pharmaceutical companies, providers, and payers to access and analyze a vast repository of medical data, including over 30 billion lab records and 325 million de-identified patient records as of October 2022. This comprehensive dataset allows users to pinpoint insights, design patient cohorts, and map patient journeys with unprecedented speed and accuracy.
Prognos Factor leverages proprietary technology called healthLOGIC, a healthcare-specific software language that enables rapid querying of patient history without scanning or key lookups. This technology, combined with Prognos' expertise in harmonizing and integrating lab test results with medical and prescription claims data, provides clients with unparalleled clinical specificity and the ability to iterate quickly over the brand lifecycle.
In March 2021, Prognos launched its Prognos Marketplace, a diverse ecosystem of integrated, patient-centric data. The Marketplace allows life sciences companies to acquire healthcare data needed for various applications, such as cohort design, patient journey studies, and health outcomes analysis. Prognos continually adds new data sources to offer the most comprehensive and diverse healthcare data offering in the market.
In October 2022, Gradient AI, a leading enterprise software provider of artificial intelligence solutions in the insurance industry, acquired Prognos Health's analytics business underwriting unit. This acquisition enabled Gradient AI to expand its medical database capabilities by integrating Prognos Health's data, including lab data, into its SAIL medical underwriting solution.

Modernizing Medicine is a healthcare technology company that specializes in developing cloud-based electronic health record (EHR) systems and solutions tailored for specific medical specialties. Their flagship products, EMA and gGastro EHR, are designed to streamline clinical workflows and documentation processes, saving time for healthcare providers. These intuitive platforms incorporate built-in medical knowledge and can adapt to individual practice preferences.
Beyond EHRs, Modernizing Medicine offers an integrated suite of products and services, including practice management, revenue cycle management, endoscopy report writing, analytics, and advisory services. Their solutions aim to address the challenges of value-based care, such as population health management, quality measure reporting, and optimizing reimbursements.
Modernizing Medicine's innovative EHR architecture emphasizes speed, convenience, and adaptability, enabling doctors to complete exams efficiently. The systems can generate notes, suggest codes, and automate billing processes, reducing administrative burdens.
In November 2022, Modernizing Medicine agreed to pay USD 45 million to resolve allegations of accepting and paying illegal kickbacks, as well as causing users to report inaccurate information for federal incentive payments. The settlement addressed three marketing programs alleged to have violated the False Claims Act and the Anti-Kickback Statute.

Modernizing Medicine

Kyruus Health is a leading provider of care access solutions that connect patients with the right healthcare providers. The company's platform integrates comprehensive provider data, enabling informed decisions and seamless access to care across various touchpoints. Kyruus Health's offerings include provider search and scheduling tools, cost transparency solutions, and data management capabilities.
Kyruus Health's technology facilitates provider matching, appointment scheduling, and digital patient intake processes. The platform enhances the overall patient experience by streamlining access to care and ensuring transparency regarding provider expertise, availability, and costs. Additionally, Kyruus Health's solutions empower healthcare organizations, such as hospitals, medical groups, and health plans, to optimize provider utilization and comply with industry mandates.
Through strategic acquisitions and partnerships, Kyruus Health has expanded its network to encompass over 425,000 providers across more than 1,000 hospitals and 500 medical groups. As of 2023, the company served over 90 million health plan members from 100 different health plan brands, solidifying its position as a leading care access platform.
Key customers and partnerships
In July 2024, Kyruus Health announced a strategic partnership with XO Health, an innovative healthcare services organization designed for self-insured employers. This collaboration aimed to enhance XO Health's digital member experience by integrating Kyruus Health's provider search and cost transparency tools, ultimately creating a seamless healthcare journey for members, providers, and payers.
Furthermore, in May 2024, Kyruus Health expanded its national provider network by integrating virtual behavioral health providers, demonstrating its commitment to improving access to mental health services. This expansion added over 30,000 virtual behavioral health providers to the Kyruus Network, enabling health plans, hospitals, and medical groups to seamlessly integrate these providers into their online directories and address access gaps.
Kyruus Health also partnered with WellHive and V3 Gate to support the Veterans Health Administration (VHA), aiming to improve care for all Veterans by accelerating access to care through centralized appointment management across VHA sites.

Kyruus

AKASA is a healthcare technology company that leverages advanced generative AI and machine learning models to address administrative inefficiencies and financial challenges in the revenue cycle management (RCM) process. Their AI solutions are specifically trained on vast amounts of clinical and financial data to comprehend the nuances of the healthcare industry.
AKASA's platform is powered by large language models and generative AI capabilities akin to ChatGPT, but optimized and tailored for the healthcare domain. Their AI understands clinical context, grasps the intricate details of health systems, and is designed to integrate directly into staff workflows, enabling automation of routine tasks and improving operational efficiencies.
The company takes an "expert-in-the-loop" approach called Unified Automation, which combines machine learning with human expertise. This allows their technology to adapt to the dynamic nature of revenue cycle operations while benefiting from the judgement of AKASA's in-house team of RCM veterans with an average of over 15 years of industry experience.
AKASA's solutions aim to reduce the substantial administrative waste associated with billing and insurance communication failures, estimated at over USD 500 billion annually in the USD 4 trillion healthcare industry. By automating comprehensive and complex tasks, AKASA enables healthcare providers to reallocate staff toward patient-facing activities and enhance care delivery.

AKASA

XSOLIS is an AI technology company that offers a platform and solutions to create a more efficient healthcare system by facilitating improved communication and alignment between healthcare providers and payers. The company's flagship product, CORTEX, is an AI-driven platform that utilizes real-time predictive analytics to continuously assign an objective medical necessity score and assess the anticipated level of care for every patient. This technology aims to eliminate waste by leveraging data science, automation, transparency, and objective insights to ensure appropriate care settings.
XSOLIS's solutions streamline patient status communications, enabling providers and payers to align on medical necessity, length of stay timelines, and appropriate care levels. The platform's AI capabilities enable the creation of live clinical profiles for each patient, recognizing patterns to generate predictive analytics for determining the most suitable care setting. CORTEX reduces the administrative burden of case reviews through its proprietary Care Level Score (CLS), allowing teams to prioritize discharge planning tasks and driving optimal workflows.
By August 2022, XSOLIS achieved a three-year revenue growth of 388%, ranking No. 1795 on the 2022 Inc. 5000 list of America's fastest-growing private companies. The company reported 111% growth in its payer network and a 44% increase in hospital partnerships in the same year.

XSOLIS

Suki AI is a healthcare technology company that develops an AI-powered voice assistant, Suki Assistant, designed to help clinicians complete administrative tasks efficiently. The Suki Assistant utilizes natural language processing and generative AI to transcribe conversations between clinicians and patients into clinical notes, populating electronic health records (EHRs) with relevant data. By automating documentation, the company aims to reduce the time clinicians spend on paperwork, claiming to shrink it by as much as 72% in family medicine settings.
Suki Assistant offers multiple modes, including ambient note generation, dictation, and voice commands. The ambient mode leverages generative AI to listen to clinician-patient interactions and auto-generate clinical notes in real-time without human intervention. Clinicians can accept, reject, or edit the AI-generated content to ensure accuracy. In addition to documentation, Suki Assistant can retrieve patient information, such as medication lists and allergies, from EHRs and provide diagnosis code recommendations.
Suki Assistant is deeply integrated with major EHR systems, including Epic, Cerner, athenahealth, Elation, and Meditech, enabling bidirectional synchronization of notes and codes. The company expanded its capabilities to support inpatient care settings in October 2023, making it the first AI-powered voice solution tailored for clinicians in hospitals. Suki Assistant operates across various platforms, including iOS, Android, web, Windows, Mac, and as a Chrome extension.
In October 2023, Suki announced the acquisition of an undisclosed company to enhance its personalization features, allowing the assistant to adapt to individual user preferences and existing workflows.

Suki

Platforms used by hospitals to manage the various aspects of patient care to improve overall efficiency, such as automating routine tasks, improving communication and coordination among healthcare providers, and enhancing patient outcomes within the hospital setting

Platforms that enable patients to actively participate in their healthcare journey by educating and engaging them, along with improving communication with healthcare providers

Platforms that help healthcare organizations analyze patient data and other performance metrics to improve decision-making and optimize resource allocation

Platforms that are designed to help hospitals and health systems manage their financial operations from patient billing and insurance claims to revenue tracking and analysis

AI-powered software solutions that are designed to help healthcare organizations streamline and automate the process of documenting patient encounters

IoT medical solutions turn traditional hospitals into smart hospitals, allowing them to streamline workflows

AI/ML algorithms optimize workflows, enable predictive modeling, and analyze patient data in healthcare

Offers software platforms that streamline and improve hospital operations

Prognos Health

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