Fifty Years is a venture capital firm that backs founders using technology to solve the world's biggest problems.  Entrepreneur-run and based in San Francisco, Fifty Years invests in companies that inspire. Specifically, they fund companies that, if successful, will be both massively profitable and make a serious dent in achieving one or more of the Sustainable Development Goals.

Fifty Years

Formic Ventures is a diversified venture capital firm that makes early-stage investments in biotechnology startups focused on human longevity as well as technology startups and companies that make human lives more meaningful.

Formic Ventures

Pareto Holdings is an early-stage investment vehicle founded by Jon Oringer and Edward Lando. We execute on dozens of investments per month and are often the first to back exceptional entrepreneurs. We are industry and geography agnostic, and specialize in pre-seeding companies. We’ve made 500+ investments to date. Unlike others, we only invest our own money with a small and mighty team around the world.

Pareto Holdings

We are a team of scientists and entrepreneurs engineering nanotechnology products to enable atomically precise manufacturing

OpenNano Pte. Ltd.

Hoxton Ventures focuses on startups that either disrupt existing industries or invent entirely new market categories. Hoxton typically invests between $500,000 and $5 million into pre-seed, seed, and Series A stage companies, and follows its capital through the life of the company.  The firm is based in London and invests all across Europe.

Hoxton Ventures

MMC Ventures is an investment firm that invests in technology companies at Seed and Series A. MMC commits to a deep understanding of each company’s underlying technology and business model to help make better decisions and be more effective partners. Transformative technology companies MMC has backed to date include Gousto, Interactive Investor, Copper, Signal AI, Synthesia, Peak and more.

MMC Ventures

Verve Ventures is a European startup investment platform for qualified and institutional investors. Their fully digital platform enables private investors to build a diversified portfolio with investments starting at CHF/EUR 10'000. Since its launch in 2010, Verve Ventures has invested more than EUR 130 million in over 100 startups. Their community consists of 5’000 registered qualified private investors, family offices, and pension funds. Several institutional investors such as a large Swiss pension fund and numerous corporates also rely on their expertise to invest in promising startups. Verve Ventures is backed by Switzerland's third-largest bank, Zürcher Kantonalbank. They have a dedicated investment team based in Zurich, Lausanne, Berlin, Paris, and Cambridge, that screens thousands of startups each year and selects the top 1% after a rigorous due diligence process. They are reshaping the European venture capital landscape and granting investors superior access to this traditionally intransparent asset class. They source the best deals, and structure rounds, and enable their investors to participate in competitive startup deals.

Verve Ventures

Ada Ventures is a venture capital fund that finds and funds extraordinary talent building breakthrough ideas for the hardest problems we face. Ada Ventures invests in UK companies at pre-seed and seed across climate, healthcare & ageing, economic empowerment.  Ada Ventures looks for underserved or unserved markets and opportunities for significant global scale and impact with a technology moat  and defensible tech, specifically a breakthrough idea.  Ada Ventures is named after Ada Lovelace, the pioneering computer programmer, and mathematician, who was never recognised during the time she lived for what she contributed to the advancement of technology and science.

Ada Ventures

Selvedge Venture operates as a venture capital firm investing for impact in age-related medical conditions.

Selvedge Venture

HOF Capital is a global multistage VC firm with $1 billion in AUM that partners with ambitious entrepreneurs from idea to IPO.

HOF Capital

MultiOmic Health

MultiOmic Health is an AI-enabled drug discovery (AIDD) start-up focused on metabolic syndrome-related diseases. It partners with carefully selected healthcare providers to source and analyse de-identified patient data and bio-samples. MultiOmic’s MOHSAIC® platform combines integrated multi-omics analysis and computational systems biology modelling with targeted wet laboratory experiments to originate novel precision therapeutic concepts that MultiOmic commercialises via partnerships with established biopharma companies.

<div>UK-based Multiomic Health is a next-generation precision medicine and an AI-enabled drug discovery company that applies computational systems biology to develop and commercialize data assets for metabolic syndrome.&nbsp;</div>

Artificial intelligence is identifying and testing new therapies faster than ever.

AI Drug Discovery

MultiOmic Health and Queen's University Belfast join forces to transform diabetic kidney disease dia

<div>
 
 UK-based Multiomic Health is a next-generation precision medicine and an AI-enabled drug discovery company that applies computational systems biology to develop and commercialize data assets for metabolic syndrome.&nbsp;
 
 
 The company&rsquo;s core product is a multi-omics data platform (MOHSAIC) that integrates genomic, epigenomic, transcriptomic, proteomic, metabolomic, and microbiome data to measure and model the molecular mechanisms of metabolic syndrome and its related conditions, such as type 2 diabetes, chronic kidney disease, atherosclerosis, and non-alcoholic fatty liver.&nbsp;
 
 
 The platform leverages AI and wet lab experimentation to generate high-fidelity datasets that can be used to identify novel biomarkers, drug targets, and therapeutic candidates. The platform also enables data-driven development of personalized therapies that can match the right treatments to the right patients based on their multi-omic profiles.
 
 
 Key customers and partnerships
 
 
 The company has entered a research collaboration with 
 <a href="https://multiomic.health/multiomic-health-forges-research-collaboration-with-northern-care-alliance-nhs-foundation-trust-in-diabetic-kidney-disease/">
 Northern Care Alliance
 </a>
 (NCA) NHS Foundation Trust in December 2022 to analyze de-identified biosamples and clinical histories collected by NCA to investigate patient stratifying biomarkers in diabetic nephropathy. It also partnered with 
 <a href="https://multiomic.health/multiomic-health-and-mesh-bio-partner-to-use-ai-to-develop-precision-medicines-and-diagnostics-for-chronic-metabolic-disease/">
 Mesh
 </a>
 in June 2022 to develop precision therapeutic and diagnostic products for patients with metabolic syndrome-related conditions.&nbsp;
 
 
 
 
 Funding and financials
 
 
 
 In May 2023, the company raised GPB 5 million (USD 6.2 million) in a 
 <a href="https://multiomic.health/multiomic-health-closes-6-2-million-funding-round-to-discover-precision-medicines-for-metabolic-syndrome-related-conditions/">
 seed funding
 </a>
 extension round led by Hoxton Ventures. The proceeds were used to demonstrate proof-of-concept of its multi-omics platform in diabetic kidney disease.
 
</div>

<div>
 
 HiberCell is a biotechnology company that develops novel therapies focused on oncology. It entered the AI drug discovery space when it acquired AI genomics analysis company Genuity Science (and its subsidiaries in Iceland and Ireland) in August 2021.&nbsp;
 
 
 Genuity Science&rsquo;s solutions include end-to-end therapeutic discovery and development services such as building custom disease datasets, discovering and prioritizing targets, identifying biomarkers, and optimizing clinical trials. Genuity Science leverages its AI-powered platform to manage, process, and analyze genomic data. HiberCell intends to use Genuity Science&rsquo;s AI/ML capabilities to advance its oncology pipeline of five programs, of which one has reached the Phase 2 clinical trial stage.
 
 
 As of March 2024, the company&rsquo;s pipeline included three drug candidates, namely: 1) HC-7366, targeting the general control nonderepressible 2 (GCN2) kinase as part of the integrated stress response (ISR) signaling pathway; 2) HC-5404, aimed at inhibiting the PKR-like endoplasmic reticulum kinase (PERK) involved in the unfolded protein response (UPR) signaling pathway; and 3) odetiglucan, a therapy targeting tumor-immune interactions within the tumor microenvironment​.&nbsp;
 
 
 Key customers and partnerships
 
 
 In December 2023, HiberCell and Merck &amp; Co partnered to conduct a Phase Ib trial to evaluate the combination therapy of belzutifan and HC-7366 for treating clear cell renal cell carcinoma. Further, in January 2021, the company partnered with Biodesix to develop an enzyme-linked immunosorbent assay as a companion diagnostic test.
 
 
 Funding and financials
 
 
 In 
 <a href="https://hibercell.com/news/hibercell-closes-67-4-million-series-b-financing-and-secures-30-million-debt-facility-from-hercules-capital/">
 May 2021
 </a>
 , HiberCell completed a Series B financing round, raising USD 67.4 million, and secured an additional USD 30 million in debt financing from Hercules Capital. The funds were expected to be used for clinical advancement of its novel therapeutic candidates. 
 
</div>

HiberCell

<div>
 
 Arbor Biotechnologies specializes in gene editing to develop novel therapeutics for a variety of indications, starting with liver-related diseases. It operates an AI-powered biodiscovery platform to discover novel CRISPR enzymes, which are sequences of repeating genetic code. To do this, its platform deploys computational search techniques, genome sequencing, gene synthesis, and high-throughput screening. This can eventually be turned into drugs or even applied to agriculture and other industrial uses. In 2018, the company announced the discovery of Cas13d, a new type of gene editing enzyme that helps to alter RNA to treat genetic diseases.&nbsp;
 
 
 As of February 2024, the company had five internal drug discovery programs, of which one was in the IND-enabling stage. It also has multiple collaborative programs under development focused on oncology and various other therapeutic areas.
 
 
 Key customers and partnerships
 
 
 The company has a long-standing partnership with Vertex Pharmaceuticals since
 <a href="https://www.businesswire.com/news/home/20190103005194/en/Vertex-and-Arbor-Biotechnologies-Establish-Collaboration-to-Discover-Novel-Proteins-to-Advance-Discovery-of-Gene-Editing-Therapies">
 January 2019
 </a>
 , which focused on developing gene-editing treatments for cystic fibrosis and four other diseases. The alliance was further extended in 
 <a href="https://www.biospace.com/article/vertex-and-arbor-strike-a-1-2-billion-deal-for-gene-editing-programs/">
 August 2021
 </a>
 and 
 <a href="https://sp-edge.com/updates/15741">
 January 2023
 </a>
 .&nbsp;
 
 
 Other partnerships included a collaboration with 
 <a href="https://www.prnewswire.com/news-releases/arbor-biotechnologies-announces-collaboration-with-ginkgo-bioworks-to-advance-the-discovery-and-development-of-precision-gene-editors-302011991.html">
 Ginkgo Bioworks
 </a>
 (December 2023) to leverage Ginkgo's R&amp;D services to further optimize Arbor's novel precision editors, a non-exclusive licensing agreement with 
 <a href="https://www.globenewswire.com/news-release/2022/02/08/2380680/0/en/EdiGene-and-Arbor-Biotechnologies-Announce-Worldwide-Non-exclusive-License-Agreement-to-Advance-Ex-Vivo-Engineered-Cell-Therapy-Programs.html">
 EdiGene
 </a>
 (February 2022) to leverage Arbor&rsquo;s platform for ex vivo oncology therapies, a strategic research and non-exclusive licensing agreement with 
 <a href="https://investors.tcr2.com/news-releases/news-release-details/tcr2-therapeutics-and-arbor-biotechnologies-establish">
 TCR2 Therapeutics
 </a>
 (January 2022) to develop allogeneic TRuC T-cell therapies using Arbor&rsquo;s CRISPR technology, and a license agreement with 
 <a href="https://www.lonza.com/news/2020-12-23-14-00">
 Lonza
 </a>
 (December 2020) to use Arbor&rsquo;s gene-editing technology for Lonza&rsquo;s bioproduction products and services.
 
 
 Funding and financials
 
 
 In its latest Series B funding round in November 2021, which was led by Ally Bridge Group, TCG Crossover, and Temasek, Arbor Biotechnologies raised USD 215 million. The proceeds of the round were earmarked to fuel the company&rsquo;s clinical development pipeline.
 
</div>

Arbor Biotechnologies

Based in the UK, Arctoris provides an automated drug discovery platform, offering fully validated research and development (R&amp;D) processes under an Experiments-as-a-Service model. The company works with biotechnology companies, AI drug discovery companies, pharma and academic institutions enabling these institutions to run experiments in Arctoris’s platform and provides on-demand access to a broad scale of datasets for AI drug discovery companies to train their algorithms.

Arctoris

<div>
 
 Frontier Medicines leverages AI/ML technologies to develop treatments for cancer-causing proteins that are dismissed by traditional pharma companies as undruggable.&nbsp;
 
 
 The company has a proprietary chemoproteomic platform which entails an approach based on the interaction of small-molecule compounds and proteins to screen a large number of targets and combine them with a protein database that contains more than 150,000 novel binding pockets (hotspots). This enables it to access 90% of the human proteome that were not previously targeted due to lack of hotspots. The platform&rsquo;s AI/ML engine incorporates a library of diverse compounds, a hotspot map that serves as the starting point for understanding the druggability of a potential therapeutic target, and lead design and generation.&nbsp;
 
 
 The company focuses on oncology and immunology target and, as of February 2024, it had five wholly-owned therapeutic programs and three AbbVie-partnered programs in its pipeline. All programs were in their discovery stage, except the company&rsquo;s lead candidate, FMC-376 (activated and inactivated forms), focused on treating different cancer types, including non-small cell lung cancer (NSCLC), colorectal carcinoma (CRC), and pancreatic ductal adenocarcinoma (PDAC), which is in the IND-enabling stage.
 
 
 Key customers and partnerships
 
 
 The company entered a USD 100 million partnership with 
 <a href="https://news.abbvie.com/2020-12-02-AbbVie-and-Frontier-Medicines-Establish-Global-Partnership-to-Discover-and-Develop-Novel-Therapies-and-E3-Degraders-Against-Difficult-to-Drug-Targets">
 AbbVie
 </a>
 In December 2020 to develop small-molecule therapeutics against hard-to-drug protein targets including around 600 E3 ligases (the enzymes that drive the ubiquitination and degradation of proteins.&nbsp;
 
 
 Funding and financials
 
 
 In July 2021, the company raised USD 88.5 million in a 
 <a href="https://sp-edge.com/updates/4347">
 Series B
 </a>
 funding round co-led by Woodline Partners LP and RA Capital Management, with equal participation from Deerfield Management Company. The proceeds were earmarked for advancing the company&rsquo;s drug pipeline and expanding operations in Boston, where its new facility was to complement the company&rsquo;s headquarters in California. 
 
</div>

Frontier Medicines

<div>
 
 Verge Genomics is a biotechnology company engaged in developing therapeutics for neurological diseases using human genomics and AI to accelerate drug discovery. The main target areas are Amyotrophic Lateral Sclerosis (ALS), Parkinson&rsquo;s Disease (PD), and Frontotemporal Dementia (FTD).&nbsp;
 
 
 It has built a proprietary all-human platform (unlike standard clinical trials that rely on animal data), called CONVERGE, that uses data sets from brain tissue samples of deceased patients with ALS and PD. While most drugs target only one gene at a time, the company claims its technology can identify hundreds of genes that cause disease and develop drugs that target all the genes at the same time. The company uses AI technology to optimize the drug discovery process as a whole.
 
 
 As of March 2024, Verge had one drug candidate in the clinical stage (Phase I) and 10 drug candidates in the discovery stage.&nbsp;
 
 
 Key customers and partnerships
 
 
 The company has partnerships with various tissue banks (such as Harvard University and University of Miami Miller School of Medicine) and several educational institutes and foundations (such as Target ALS, Answer ALS) that enabled its drug discovery platform.&nbsp;
 
 
 In addition, the company&rsquo;s customers include several pharmaceutical companies, such as 1) 
 <a href="https://www.vergegenomics.com/news-blog/verge-genomics-announces-research-collaboration-with-the-sheffield-institute-for-translational-neuroscience">
 Sheffield Institute for Translational Neuroscience (SITraN)
 </a>
 to accelerate the validation of novel drug targets and screening of drug compounds for Parkinson's disease (February 2021), 2) 
 <a href="https://sp-edge.com/updates/4146">
 Eli Lilly
 </a>
 to research and develop novel therapies to treat ALS (July 2021), 3) 
 <a href="https://sp-edge.com/updates/21707">
 Alexion
 </a>
 to identify novel drug targets for rare neurodegenerative and neuromuscular diseases (September 2023), and 4) 
 <a href="https://www.vergegenomics.com/news-blog/verge-genomics-and-the-pritzker-neuropsychiatric-disorders-research-consortium-form-cutting-edge-schizophrenia-research-collaboration">
 Pritzker Neuropsychiatric Disorders Research Consortium
 </a>
 to analyze data from schizophrenic patient&rsquo;s brain tissue with Verge&rsquo;s technology (October 2023).
 
 
 Funding and financials
 
 
 In December 2021, Verge raised USD 98 million in an oversubscribed 
 <a href="https://sp-edge.com/updates/7426">
 Series A
 </a>
 funding round led by BlackRock. The funds were used to scale up its pre-clinical and clinical candidate programs in the pipeline and enhance its lead therapeutics through clinical testing. 
 
</div>

Verge Genomics

SaaS (Software-as-a-Service) companies providing their ML platform to other pharma companies for drug discovery services such as target selection, validation and lead optimization.

SaaS (Software-as-a-Service) companies providing their ML platform to other pharma companies to design and run preclinical experiments.

SaaS (Software-as-a-Service) companies providing their ML platform to other pharma companies to identify biomarkers (measurable biological signs used to determine disease progression) and predict drug response. 

SaaS (Software-as-a-Service) companies aggregating and analyzing biomedical data with the help of AI to generate insights across the drug development pipeline.

Biotechnology companies that have integrated AI as a core component of their in-house drug development process. They typically have a few in-house drug development programs, and also collaborate with pharma companies to develop certain drugs.

Companies leverage GenAI to support drug discovery through accelerated drug designing

Companies offer AI/ML-based SaaS products to accelerate the discovery and development of novel therapeutics

Offers AI/ML-based solutions to accelerate drug discovery and development

PROMINENT_CATEGORY

<div>
 The AI drug discovery company MultiOmic Health, based in the UK, has developed unique biomarkers aimed at categorising patient profiles for diabetic kidney disease (DKD). The objective of this development is to enable accurate categorisation of DKD patients in relation to their disease progression.
These biomarkers are created to increase the efficiency and success rate of DKD trials through precise patient selection for clinical studies. The company's capability to recognise patient endotypes and forecast the rate of disease progression is predicted to assist in the determination of a proactive treatment plan.
</div>

MultiOmic Health

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