Founded in 2015, CSC Upshot Ventures is an early-stage venture fund focusing on providing seed capital to technology companies at scale. The firm seeks to invest in companies operating in the enterprise, artificial intelligence, healthcare, Fintech, and the marketplace. In close partnership with AngelList, CSC Upshot Ventures built a new model of venture investing based on the needs of founders, investors, and startup communities.

CSC Upshot

Lightspeed Venture Partners is a venture capital firm that engages in consumer, enterprise, technology, and cleantech markets. It focuses on seed, early-stage, later-stage, expansion-stage, start-ups, growth companies, and incubation, and specializes in debt financing for start-ups and growth companies. Lightspeed Venture Partners invests in various sectors that include enterprise, consumer, big data, bitcoin, enterprise technology, cleantech, mobile, internet, financial technology, cloud solutions, e-commerce, storage, media, networking, energy, and software, software-as-a-service, information technology, biotechnology, and social. It mainly invests in countries such as the United States, Europe, Israel, China, and India.

Lightspeed Venture Partners

Knoll Ventures is an early-stage venture capital firm that invests in B2B technology enabled companies prior to the Series A round.

Knoll Ventures

Moso Capital is a firm founded by Y Combinator alumni that makes small investments in early stage companies.

Moso Capital

Moonshots Capital makes seed stage investments in technology startups led by exceptional founders who are building products that “re-imagine” work and personal life in large and growing markets. We bring a disciplined approach to the investment process to identify companies with “moonshot” potential.

Moonshots Capital

Notable Capital is named for the founders we invest with, the ideas they pursue, the causes they champion, and the remarkable companies they build. Notable is a U.S.-based venture capital firm focused on early-to-growth stage companies in cloud infrastructure and business and consumer applications across the U.S., Israel, Europe, Latin America, and select go-global opportunities. Notable portfolio companies include Affirm, Airbnb, Block, Brightwheel, Drata, Handshake, HashiCorp, Ibotta, Orca Security, Quince, Slack, Slice, StockX, Stori, Vercel, Zendesk, and more.

Notable Capital

Western Technology Investment is a venture capital firm that specializes in offering acquisition financing to revenue-generating firms. The firm provides debt and lease financing to venture capital backed technology companies.

Western Technology Investment

Transformation Capital is the successor management company to Leerink Transformation Partners LLC (“LTP”).11  LTP was founded in 2016 by Todd Cozzens and Jared Kesselheim, MD together with SVB Leerink Capital LLC (formerly Leerink Capital Partners LLC) (“Leerink Capital”), an affiliate of SVB Leerink LLC (“Leerink”), a leading healthcare investment bank.  Leerink Capital provided seed capital to Fund I (approximately 3% of capital commitments) and operational support. In January 2019, SVB Financial Group (“SVB”), the holding company of Silicon Valley Bank, a U.S.-based high-tech commercial bank, acquired the Leerink businesses including Leerink Capital.  Todd Cozzens, Jared Kesselheim, MD, and SVB expect to agree to a mutually beneficial ongoing relationship in which Transformation Capital (as an independent management company owned by Todd Cozzens, Jared Kesselheim, MD, and Michael Dixon and not affiliated with SVB or Leerink Capital) shall manage Fund II and whereby Transformation Capital shall manage Fund I’s investment portfolio pursuant to a sub-advisory agreement with SVB (or an affiliate).  Transformation Capital has the same operational leader, Kevin Brown, formerly CFO of Leerink Capital, and Transformation Capital expects to continue to derive benefits from its ongoing relationship with Leerink and SVB.

Transformation Capital

PlushCare

PlushCare is a San Francisco-based tech startup that makes it easy to find and meet with a doctor online, even on the same day. Their mission is to provide patients with the best doctors and the best medical experience in a friendly and personalized way. The company's technology platform enables over 100,000 patients (and growing) to get care from a board-certified doctor online. With an NPS of 90 and an App Store rating of 4.9, they strive to provide the healthcare experience that patients deserve. PlushCare has also been developing Coronavirus at home testing.

<div><p>PlushCare is a telehealth provider which facilitates online video visits with a doctor. It allows users to connect with doctors through smartphones. The company's technology is integrated with most major insurers, labs, and pharmacies, further easing the access to patients. It treats many acute and chronic conditions and offers primary care, mental healthcare, and urgent care services. With over 225,000 patients treated as of September 2020, PlushCare visits are priced at USD 14.99 per month. In addition to the monthly fee, it charges a fee of USD 99 on the first visit of a non insured member (copay is payable by insured members for their first visit). Plushcare membership includes unlimited in-app messaging, access to an online care team, and same day appointments.</p></div>

More important now than ever, telehealth will long outlast the pandemic that drove its growth.

Telehealth

<div>
  <p>
    PlushCare is a telehealth provider which facilitates online video visits with a doctor. It allows users to connect with doctors through smartphones. The company's technology is integrated with most major insurers, labs, and pharmacies, further easing the access to patients. It treats many acute and chronic conditions and offers primary care, mental healthcare, and urgent care services. With over 225,000 patients treated as of September 2020, PlushCare visits are priced at USD 14.99 per month. In addition to the monthly fee, it charges a fee of USD 99 on the first visit of a non insured member (copay is payable by insured members for their first visit). Plushcare membership includes unlimited in-app messaging, access to an online care team, and same day appointments.
  </p>
  <p>
    Plushcare raised USD 23 million in June 2020 from investors led by Transformation Capital bringing the total funding of the company to USD 31 million. The funds are expected to be used for expanding its staff from 50 employees to 100 employees by June 2021 and fueling its marketing budget.
  </p>
</div>


<div>
  <p>
    Nice Healthcare is a US based telehealth company with a focus on primary care services to business-to-business (B2B) clients. Once the employer signs its employees with Nice (at a cost of USD 30 to USD 36 per employee per month), employees do not have to incur out of pocket expenses for Nice services and can schedule virtual or home visits within the time frames specified by the company. It connects patients with practitioners through a mobile app over video calls or text messages. Members can also request home visits which will be completed within a few hours, as claimed by the company. As of March 2022, Nice was operating in twelve states, and had over 400 small and medium enterprises (SMEs).
  </p>
  <p>
    In March 2022, the company raised USD 30 million in Series A financing led by DNA Capital which has been earmarked to expand its platform&rsquo;s reach among small and medium businesses. Additionally, the company is hiring three members for its management team to support the continuing growth of the organization.
  </p>
  <p>
  </p>
</div>


Nice Healthcare

<div>
  <p>
    Amicomed is a cloud-based Software-as-a-Service (SaaS) platform which provides blood pressure monitoring services. It collects blood pressure data of patients from at-home devices, applies algorithms, and assesses the fluctuations in the blood pressure. Physicians can be connected and provided with blood pressure data of their patients in order to facilitate their workload, enabling more personalized management of patients regarding medication and lifestyle indications. 
  </p>
  <p>
    Amicomed can also recommend actionable and personalized lifestyle interventions such as daily diet and exercises via virtual coaching.
  </p>
</div>


Amicomed

<div>
  <p>
    Winston is a men&rsquo;s health telemedicine platform that treats common issues impacting men such as sexual problems, hair loss, acne, and cold sores. Winston allows patients to consult doctors, place orders for prescription drugs, and offers free delivery to the homes of patients. 
  </p>
  <p>
    The Toronto-based company aims to avoid men deferring doctor visits or withholding sensitive information. The consultation fee is covered by the provincial health plan, but the prescriptions are billed to the customer.
  </p>
</div>


Winston

<div>
  <p>
    Eko Health is a cardiopulmonary digital health company that aims to improve heart and lung care for patients using sensors and artificial intelligence. The company produces connected handheld digital stethoscopes with electrocardiogram functionality to detect heart rhythm abnormalities using artificial intelligence (AI) algorithms. In 2020, the company obtained 501(k) FDA clearance for multiple algorithms that help detect heart murmurs and atrial fibrillation, or AFib. These algorithms were used in 2022 to develop the Eko App, which pairs to the company's stethoscopes for report generation, information sharing and carrying out examinations. 
  </p>
  <p>
    The company operates on a fee per unit B2B2C model and a D2C model, where it provides its technology to medical practitioners or patients for diagnostic purposes.
  </p>
  <p>
    In February 2023, Eko 
    <a href="https://sp-edge.com/updates/16677">
      launched SENSORA
    </a>
    , a cardiac disease detection platform that combines the company&rsquo;s existing digital stethoscopes with a machine learning-based platform. The platform enables primary care physicians to detect structural murmurs and assess heart arrhythmias by using a database of heart sounds to compare and identify anomalies in a patient's heart beat. 
  </p>
  <p>
    In April 2024, Eko 
    <a href="https://sp-edge.com/updates/28111">
      obtained FDA 510(k) clearance
    </a>
     for its AI-aided cardiac tool, Eko Low Ejection Fraction Tool (ELEFT). The tool is designed to assist providers in early detection of low ejection fraction, a significant sign of heart failure.
  </p>
  <p>
    <b>Funding and financials</b>
  </p>
  <p>
    In March 2022, raised a further USD 30 million in an extension to its Series C round, which began November 2020. The total funds raised by the company stood at USD 126 million as of March. These funds have been allocated to support further commercialization efforts and develop new products for the company.
  </p>
  <p>
  </p>
  <p>
  </p>
  <p>
  </p>
</div>


<div>
  <p>
    Dialogue partners with employers and health insurers to offer telehealth services to their employees and members. The users have 24/7 access to doctors, nurses, and other healthcare professionals via audio, video, and chat options for wide arrays of physical and mental health needs, artificial intelligence-enabled (AI-enabled) triage, referrals, and prescription renewals. 
  </p>
  <p>
    The company launched its trademarked Integrated Health Platform in January 2021 to consolidate its virtual care,  wellness programs, mental healthcare services, and Employee Assistance Program (EAP) onto a single platform. The company claims to be the only integrated health and wellness B2B platform in Canada. 
  </p>
  <p>
    <b>Key Customers and partnerships</b>
  </p>
  <p>
    Dialogue had direct relationships with over 2,000 customers across Canada and Germany as of December 2020 and served around 50,000 organizations through these partnerships. In addition, the number of members with access to the virtual platform topped 1 million in January 2021. 
  </p>
  <p>
    <b>Fundings and financials</b>
  </p>
  <p>
    As of March 2021, Dialogue was planning to raise CAD 100 million (USD 80 million) from an initial public offering that will be listed on the Toronto Stock Exchange under the ticker symbol &ldquo;CARE.&rdquo; 
  </p>
  <p>
    In Q2 2023, net losses reduced significantly YoY to CAD 5.8 million (USD 4.3 million) from CAD 8.4 million (USD 6.3 million) in Q2 2022. Top-line revenue met internal expectations, growing 17.2% YoY to CAD 25.5 million (USD 19.0 million), driven by &nbsp;an increase in new members (by 18.6% YoY), 
    an expansion of the attach rate as existing customers added more services, and full-quarter contributions from Tictrac.
     
    Dialogue Health has not provided any forward-looking guidance as the company has entered into an agreement to be 
    <a href="https://investors.dialogue.co/English/news/news-details/2023/Dialogue-to-be-Acquired-by-Sun-Life/default.aspx">
      <u>acquired by financial services company Sun Life Financial</u>
    </a>
     for a consideration of CAD 365 million (USD 270 million) or CAD 5.15 (USD 3.82) per share. The transaction is expected to close in Q4 2023. Post acquisition, Dialogue will delist from the Toronto Stock Exchange but will continue to operate as a standalone entity under the &ldquo;Sun Life Canada&rdquo; brand from its head office in Qu&eacute;bec. 
  </p>
  <p>
  </p>
</div>


Dialogue

IoT is used by most telehealth providers to operate virtual services

All telehealth players are involved in digital health via virtual offerings

Industry players offer varying degrees of personalization for each target audience

Some players offer technology and platforms to healthcare providers, converting physical-only services into virtual services

Specific telehealth offerings focus on diversity and inclusion, providing care to LGBTQ+ or BIPOC populations

Generative AI is used to streamline administrative tasks such as clinical note-taking

Primary care through virtual consultations for general health-related concerns using a digital platform or mobile app. 

PlushCare

Telehealth

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