CellRx

Based in the UK, CellRx is a manufacturer and supplier of an animal-free growth factor additive “Short-AE-IGF-1” produced using  a strain of E.coli and a proprietary fermentation process for use in research, bioprocessing and large-scale commercial cell-culture. “Short AE-IGF-1” (herein Short IGF 1) is the company’s first commercialized product. The company also offers microbial fermentation services (upto 2000 liters) using its technology and bioprocess optimization services including, process flow, unit operation selection and optimization, upstream and downstream process scale up and optimization, and cell bank establishment, maintenance and validation.

<div>Based in the UK, CellRx is a manufacturer and supplier of an animal-free growth factor additive “Short-AE-IGF-1” produced using  a strain of E.coli and a proprietary fermentation process for use in research, bioprocessing and large-scale commercial cell-culture. “Short AE-IGF-1” (herein Short IGF 1) is the company’s first commercialized product. The company also offers microbial fermentation services (upto 2000 liters) using its technology and bioprocess optimization services including, process flow, unit operation selection and optimization, upstream and downstream process scale up and optimization, and cell bank establishment, maintenance and validation.</div>

Making meat sustainable over the long term.

Cell-cultured Meat

<div>
 
 Based in the UK, CellRx is a manufacturer and supplier of an animal-free growth factor additive “Short-AE-IGF-1” produced using  a strain of E.coli and a proprietary fermentation process for use in research, bioprocessing and large-scale commercial cell-culture. “Short AE-IGF-1” (herein Short IGF 1) is the company’s first commercialized product. The company also offers microbial fermentation services (upto 2000 liters) using its technology and bioprocess optimization services including, process flow, unit operation selection and optimization, upstream and downstream process scale up and optimization, and cell bank establishment, maintenance and validation.
 
 
 CellRx’s Short IGF 1 claims to be 100x more potent than insulin and matches or outperforms other alternative growth factors such as IGF-1, Long-R3-IGF-1 with higher recombinant protein production, reduced cell death, and higher cell density. Short IGF 1 also comes in a liquid form which is reportedly more stable and can be directly added into cell culture media,  whereas the conventional growth factors come in a powder format that needs to be transformed back into a liquid, increasing the risk of influencing pH and presence of chemicals in cell culture. Short-AE-IGF-1 is priced at USD 8,000 per 0.5g whereas Long-R3-IGF-1 and insulin are priced at USD 25,000 per 0.5g and USD 17,000 per 50g respectively.
 
 
 As of March 2022,  The company offers its Short IGF 1 for laboratory research and large-scale in vitro biopharmaceutical manufacturing use only, and has signed NDA’S with cultivated meat players for the production of customized growth factors. The company also noted that the cost of growth factors have to be reduced further to enable large-scale cell-culture meat production and that it may have to modify its business model for producing growth factors for cultivated meat producers.
 
 
 
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 Dutch company Mosa Meat is a cell-cultured meat startup founded by Dr. Mark Post of Maastricht University, who produced the world's first lab-grown meat burger in 2013. The startup produces meat by growing myosatellite cells (muscle stem cells) extracted from an animal in a bioreactor fed with nutrient-dense medium.
 
 
 <a href="https://sp-edge.com/updates/2765">
 In May 2021
 </a>
 , Mosa Meat announced that it was able to reduce the cost of its cell-cultured fat by 66x, setting it on course to achieve price parity with conventional meat. The company successfully replaced the fetal bovine serum (FBS) from its growth medium in July 2020, which led to an 88x cost reduction in its medium. According to the company, the replacement of FBS and the selection of the cheapest suppliers have contributed to the reduction in cost. The company claimed its fat medium was only 1.52% of the cost reported back in September 2019. The startup planned to bring down the production cost and price of the burger to EUR 9 at commercialization from the initial EUR 250,000 (approximately USD 297,000) per burger cost in 2013.&nbsp;&nbsp;In May 2023, the company opened the new 30,000 sq foot facility completing its Center for Advanced Meat Production, Upscaling, and Sustainability (C.A.M.P.U.S), increasing its total production footprint to over 79,000 sq feet. Claimed to be the largest cultivated meat campus in the world, the facility is capable of producing tens of thousands of cultivated hamburgers and is designed to be expandable as demand grows.
 
 
 In 
 <a href="https://sp-edge.com/updates/21645">
 September 2023
 </a>
 , Mosa Meat became the first cultivated meat company to attain B Corp certification. The company also announced plans to apply for regulatory approval in countries worldwide.
 
 
 
 
 Key customers and partnerships
 
 
 
 
 In 
 <a href="https://sp-edge.com/updates/14175">
 November 2022
 </a>
 , Mosa Meat entered into an agreement with Singapore-based contract development and manufacturing organization (CDMO) Esco Aster to commercialize the company&rsquo;s cultivated beef in Singapore.
 
 
 
 
 Funding and financials
 
 
 
 In its last funding round (
 <a href="https://sp-edge.com/updates/2734">
 February 2021
 </a>
 ), it raised USD 10 million in a third Series B round led by Blue Horizon Ventures as well as existing and new investors including Nutreco and Jitse Groen. Mosa Meat intended to use this to scale up its production, expand its pilot plant facility, expand its labor force, develop an industrial-sized production line, and commercialize its products. It planned to commercialize its product by 2022 and to commission the first high-volume production plant by 2025. 
 <a href="https://sp-edge.com/updates/6188">
 In October 2021
 </a>
 , Mosa Meat&rsquo;s and animal nutrition company Nutreco&rsquo;s joint venture &ldquo;Feed for Meat,&rdquo; received a grant of USD 2 million from the European REACT-EU recovery assistance program. The funds were expected to be allocated to R&amp;D and to lower the expense of the base media.
 
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Mosa Meat

<div>
 
 Eat JUST (known as Hampton Creek prior to 2018) is a food technology company founded in 2011 that initially developed plant-based alternatives, such as Just Mayo made from yellow peas and Just Egg made from mung bean. It then expanded to cell-cultured chicken and beef. In 2018, the startup developed cell-cultured chicken nuggets that cost USD 50 each to produce. In December 2020, the company became the first startup to sell cultured meat following approval from the Singapore Food Agency (SFA), selling to 1880, a restaurant in Robertson Quay, Singapore. The cultured meat is sold under Eat JUST&rsquo;s &ldquo;GOOD Meat&rdquo; brand. In 
 <a href="https://sp-edge.com/updates/15768">
 January 2023
 </a>
 , the company received regulatory approval from the SFA for the use of serum-free media in the production of cultivated meat, marking another milestone for the company. The company also stated that it is on track to reach price parity with conventional meats by 2027, and plans on installing vessels that can handle 100,000 liters or more to further drive down the price of its serum-free media.
 
 
 In 
 <a href="https://sp-edge.com/updates/17221">
 March 2023
 </a>
 , GOOD Meat received a &ldquo;no questions&rdquo; letter from the Food and Drug Administration (FDA) in the US, indicating that the FDA has accepted the company&rsquo;s conclusion that its first poultry product, cultivated chicken, is safe to eat. In June 2023, the company became the first cultivated meat producer to receive label approval from the USDA. Later that month, the company 
 <a href="https://sp-edge.com/updates/19588">
 received the grant of inspection
 </a>
 from the USDA for its Alameda demonstration plant, and JOINN Biologics (GOOD Meat&rsquo;s contract manufacturing partner), allowing the company to begin the sale of its cultivated chicken in the US.
 
 
 Following necessary approvals from the USDA, GOOD Meat&rsquo;s chicken will first be available to customers at a restaurant operated by Jos&eacute; Andr&eacute;s Group in Washington, D.C. Jos&eacute; Andr&eacute;s Group operates more than 30 restaurants across the US.
 
 
 The company was also working on gaining approval elsewhere in the world for the sale of its cell-cultured meat. In 
 <a href="https://sp-edge.com/updates/5242">
 September 2021
 </a>
 , the startup stated that the authorities in Qatar intended to grant regulatory approval for the sale of cell-cultured meat &ldquo;very soon,&rdquo; while it announced plans to build a commercial plant to produce cell-cultured meat in the country, in partnership with Doha Venture Capital and the Qatar Free Zone Authority. The startup is also expected to build two manufacturing facilities in northern California and Singapore to scale up the production capacity to more than 50,000-liter vessels of lab-grown chicken in the US and Asia (from the current 1,200 liters). 
 <a href="https://sp-edge.com/updates/9244">
 In March 2022
 </a>
 , the company announced breaking ground on its new manufacturing facility in Singapore&mdash;the largest in Singapore post-completion&mdash;slated to be complete in two years at a cost of USD 120 million. Further, in 
 <a href="https://sp-edge.com/updates/11035">
 June 2022
 </a>
 the company also broke ground in JTC Bedok Food City, which will house Asia&rsquo;s largest bioreactor for cultivated meat production, slated to begin operations in Q1 2023.
 
 
 Key customers and partnerships
 
 
 In April 2021, it collaborated with the food delivery partner, foodpanda, for the world's first home delivery service of cell-cultured meat in Singapore, produced under its GOOD Meat brand. The dishes were prepared by 1880 and included katsu chicken curry, chicken coconut rice, and chicken caesar salad. It was priced at SGD 20 (USD 15), starting on Earth Day (April 22). In May 2021, GOOD Meat&rsquo;s cell-cultured meat was added to JW Marriott Singapore South Beach&rsquo;s menu. 
 <a href="https://sp-edge.com/updates/8755">
 In February 2022,
 </a>
 Eat Just announced that it will be selling GOOD Meat chicken in Singapore&rsquo;s food hawker stalls. The company partnered with Loo&rsquo;s Hainanese Curry Rice, a food stall in the Tiong Bahru region, and sold curry rice dishes with cultivated chicken for SGD 4 (~USD 3). The company also launched its cultivated chicken satay at Singapore&rsquo;s food hawker stalls in 
 <a href="https://sp-edge.com/updates/10542">
 May 2022
 </a>
 , this time partnering with family-run, Michelin-plate hawker Kee Eng Kee (KEK). KEK served customers cultivated chicken satay alongside a cucumber slaw, peanut sauce, Singapore bee hoon (stir-fried vermicelli), and KEK signature tofu in a dish priced at SGD 13.8 (~USD 9.94).&nbsp;
 
 
 To accelerate development of its cultivated chicken products, Eat JUST partnered with US-based multinational food processing company Archer Daniels Midland (ADM) 
 <a href="https://sp-edge.com/updates/10516">
 in May 2022
 </a>
 . The partnership&rsquo;s focus was to develop a low-cost growth media with ADM optimizing GOOD Meat&rsquo;s existing nutrient mix. The company also partnered with ABEC 
 <a href="https://sp-edge.com/updates/10724">
 in May 2022
 </a>
 to build the world&rsquo;s first large-scale cultivated meat facility. In 
 <a href="https://sp-edge.com/updates/15193">
 December 2022
 </a>
 , the company partnered with Huber&rsquo;s Butchery in Singapore to sell and serve cultivated chicken products.
 
 
 
 
 
 Funding and financials
 
 
 
 In
 <a href="https://sp-edge.com/updates/12427">
 
 August 2022
 </a>
 , the company bagged a USD 25 million investment along with a strategic partnership from Alibaba Group-backed private equity firm C2 Capital partners. Together, the companies are set to work toward expanding Eat JUST&rsquo;s footprint in the Chinese market. Later, in 
 <a href="https://sp-edge.com/updates/21471">
 September 2023
 </a>
 , the company raised an undisclosed amount in new funding led by VegInvest/Ahimsa Foundation. The funding was to be deployed towards improving the quality and profitability of Eat JUST's products.
 
 
 
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Eat JUST

<div>
 
 SCiFi Foods (previously Artemys Foods) is a start-up developing cell-cultured beef. The startup uses pluripotent stem cells that differentiate into muscle or fat cells, which it separates into different bioreactors to cultivate. With the successful production of cultured beef, the company plans to launch a hybrid burger made from a blend of plant-based meat and cell-cultured meat by 2024 following regulatory approval. The startup believes it will be difficult to replicate the texture of beef burgers just by combining muscle and fat cells, without the connective tissues. Hence it sees blending muscle cells and fat cells with plant-based proteins as the best method to replicate the beef burger. In 
 <a href="https://sp-edge.com/updates/11598">
 July 2022
 </a>
 the company announced a breakthrough in R&D which allowed them to grow beef cells in single-cell line suspension leading to a reduction in cost by more than thousand fold. The company expects to reach price parity following this milestone.
 
 
 In
 <a href="https://sp-edge.com/updates/13063">
 September 2022
 </a>
 the company partnered up with Michigan State University to finalize development and test scaling of its hybrid beef burger.
 
 
 In 
 <a href="https://sp-edge.com/updates/10966">
 June 2022
 </a>
 , the company raised USD 22 million in a Series A funding round led by Andreessen Horowitz(a16z) which brings the total funding raised by the company to USD 29 million. The planned use of the funds are to scale up R&D, attract new hires and marketing strategy expenses.
 
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SCiFi Foods

SuperMeat is a cellular agriculture startup developing cultured chicken meat. The company hopes to initially launch blended products that will include both plant-based and cell-cultured meat (70% plant-based meat to 30%&nbsp; cell-cultured meat) offering a better taste profile than plant-based meat while costing less than 100% cell-cultured meat.&nbsp;SuperMeat filed a patent application in April 2018, covering the manufacturing of blended products by combining cell-cultured chicken and plant-based meat.In November 2020, the startup opened the world’s first cell cultured meat restaurant in Tel Aviv to give the opportunity to select diners to taste its products. The establishment operates similar to a test kitchen, for SuperMeats products that are still in the development phase. In <a href="https://sp-edge.com/updates/21733">September 2023</a>, The Orthodox Union (OU) certified SuperMeat’s cultivated chicken as “kosher.”Further, the OU and SuperMeat will collaborate on establishing guidelines for the industry.Key customers and partnershipsIn January 2018, SuperMeat entered into a strategic partnership with PHW, one of Europe's biggest poultry producers. According to the partnership, PHW will support SuperMeat in R&amp;D and strategic positioning of their products in Europe. <a href="https://sp-edge.com/updates/9319">SuperMeat signed an MoU with PHW</a> in March 2022 to supply cultivated meat products to Europe. <a href="https://sp-edge.com/updates/8997">In March 2022</a>, SuperMeat partnered with Ajinomoto to set up a joint venture to accelerate the commercialization of cultivated meat while focusing on developing a cost-competitive cell-growth media. In <a href="https://sp-edge.com/updates/11867">July 2022</a>, the company signed an MoU with Switzerland’s largest retail supermarket chain and leading meat manufacturer, Migros to expedite production and distribution of cultured meat at a commercial scale with a focus on European markets.Funding and financialsSuperMeat raised an undisclosed amount in a Series A funding round held in February 2021. In <a href="https://sp-edge.com/updates/10945">June 2022</a> the company received grant funding from the Israel Innovation Authority to set up what SuperMeat claims to be the world's largest high throughput screening system for identification and optimization of cultured meat ingredients, supplemental inputs, and cellular scaffoldings for the production of cultivated meat.

SuperMeat

<div>
 
 Gourmey is a startup developing foie gras using cell culture technology. The startup is developing cell-cultured foie gras using cells from a duck egg grown in a cultivator with feed media matching the nutrients of a duck's natural diet. Once the cells are multiplied, the company adjusts the nutrients in the media, increasing the plant based fats to replicate the effects of forced feeding at the cellular level. Gourmey has not unveiled a prototype or stated an expected market entry date for its product. In July 2021, the startup announced development of “Structured restaurant-grade meats” including poultry filets in the style of duck, chicken, and turkey. Gourmey is said to be co-developing the product line with chefs ahead of a soft launch in various restaurants.
 
 
 In 
 <a href="https://sp-edge.com/updates/13534">
 October 2022
 </a>
 , the company raised EUR 48 million (~USD 48 million) in a Series A funding round led by Earlybird Venture Capital with the participation of Keen Venture Partners, Omnes Capital, Discovery, and others. The funding was intended for advancing from R&D toward commercialization.
 
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Gourmey

Provide sustainable solutions for animal slaughter through the use of biotechnology

Developers of bioreactors and other technologies used in cell cultured meat production. Industrial scaling and efficiency gains are key areas of interest for the startups in the industry.

Producers of growth media for cell cultured meat production and ingredients for meat and meat analogue (cell cultured, plant-based) producers; which can include cell culture meat paste, culture fat etc. Producers of growth media, mainly focuses on startups developing alternative growth media to fetal bovine serum (FBS) using plant-based or other sources.

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