Natacor Inc. is a firm that provides financial and business advising as well as capital investments.

Natacor Inc.

The Golden Triangle Angelnet is a not-for-profit corporation operating under the Ontario Ministry of Research and Innovation's Angel Network Program. It is a members-only organization comprised of Angel investors seeking investment opportunities in promising, early-stage businesses. In addition to the financial support, as part of their all-encompassing commitment to assist the companies they invest in, its Angels often provide valuable mentorship and access to strong relationship capital networks to their investee companies. It is this priceless assistance that aids in the facilitation of learning, networking, and growth.

Golden Triangle Angel Network

NorthSpring Capital Partners provides risk capital to small and medium sized companies with the goal of creating value. Investments range between $250,000 and $1 million in the form of subordinated debt and/or equity across a variety of traditional industries located in Southern Ontario. NorthSpring takes a flexible approach when reviewing investment opportunities and tailors its investment structure to fit the unique aspects of the business.

NorthSpring Capital Partners

MaRS Investment Accelerator Fund (IAF) is an early stage venture capital firm based in Toronto. Since 2008, we have partnered with over 150 companies built by extraordinary founders. For more information, please visit www.marsiaf.com

MaRS Investment Accelerator Fund

Intellijoint Surgical

Intellijoint Surgical is a Canadian medical device company committed to assisting orthopedic surgeons to meet their surgical objectives. Focused first on hip surgery, Intellijoint Surgical’s affordable Smart Tools enhance surgeon accuracy, improve patient outcomes, and increase hospital economic efficiencies. Intellijoint HIP is a low cost, easy to use Smart Tool that assists surgeons with the accurate selection, positioning, and alignment of implants during hip replacement surgery. The device uses a combination of hardware and software and integrates miniature optical sensors and microelectronics. Without altering surgical techniques or workflow, intelligent HIP provides surgeons with quantitative intra-operative data regarding changes in cup position, leg length, and offset while adding approximately 3-5 minutes to surgery. This data expedites decision-making and improves accuracy in achieving pre-operative planned targets, ultimately improving patient outcomes and reducing outliers. In 2016, The company has received the North American Frost & Sullivan Enabling Technology Leadership Award.

Intellijoint Surgical develops and commercializes surgical planning and navigation solutions for total hip and knee replacements. Their flagship products are Intellijoint HIP, which provides real-time intraoperative implant measurements for accurate alignment and restoration of leg length and offset in total hip arthroplasty, and Intellijoint KNEE, which aids in intraoperative measurements, instrumentation alignment, and bony cuts for implant positioning in knee replacements. Intellijoint's technologies are designed to improve patient outcomes with fast, easy, and accurate navigation without adding time to surgical workflows. As of October 2023, the company announced a workforce reduction to streamline operations and achieve profitability, indicating challenges in scaling a medical technology business in Canada. Intellijoint has been generating annual sales of around USD 10 million. In March 2022, Humber River Hospital became the first public hospital in Canada to purchase Intellijoint HIP, funded by the hospital's foundation. This marked a significant milestone for the Kitchener-based company. The company's products are widely used globally, with over 20,000 procedures performed around the world as of March 2022, primarily in the US, Australia, New Zealand, and Japan.

Intellijoint Surgical Announces Reduction in Workforce, Focusing on Profitable Growth

Humber River first in Canada to buy Intellijoint HIP

For homegrown medical technology startups, Canada is a tough market to break into

Pushing the envelope in MedTech with emerging technologies

Next-gen Medical Devices

Intellijoint Surgical opens access for free use of its most differentiated product in orthopaedics

Intellijoint Surgical develops and commercializes surgical planning and navigation solutions for total hip and knee replacements. Their flagship products are Intellijoint HIP, which provides real-time intraoperative implant measurements for accurate alignment and restoration of leg length and offset in total hip arthroplasty, and Intellijoint KNEE, which aids in intraoperative measurements, instrumentation alignment, and bony cuts for implant positioning in knee replacements. Intellijoint's technologies are designed to improve patient outcomes with fast, easy, and accurate navigation without adding time to surgical workflows. As of October 2023, the company announced a workforce reduction to streamline operations and achieve profitability, indicating challenges in scaling a medical technology business in Canada. Intellijoint has been generating annual sales of around USD 10 million. In March 2022, Humber River Hospital became the first public hospital in Canada to purchase Intellijoint HIP, funded by the hospital's foundation. This marked a significant milestone for the Kitchener-based company. The company's products are widely used globally, with over 20,000 procedures performed around the world as of March 2022, primarily in the US, Australia, New Zealand, and Japan.

Convergent Dental, Inc. is a privately owned dental equipment and technology company. Its flagship product, Solea, is the only CO2 laser cleared by the FDA for all-tissue indications, delivering an anesthesia-free, blood-free, and suture-free experience for dentists and patients. Solea represents a breakthrough in dental laser technology, offering a distinct experience compared to traditional instruments or earlier laser treatments.
Solea is a novel 9.3-micron CO2 laser that nears the peak absorption of hydroxyapatite (enamel), enabling it to vaporize enamel with speed and precision. This unique wavelength, coupled with computer-controlled motors (galvos) that manipulate the beam thousands of times per second, allows dentists to perform procedures ranging from hard tissue to soft tissue with total control and efficiency.
A key feature of Solea is its variable-speed foot pedal, which lets dentists seamlessly transition from hard to soft tissue by adjusting the pressure applied. This intuitive design streamlines the learning curve for dentists accustomed to using a drill. Solea's three ergonomic handpieces – Contra-Angle, Straight, and Ultraguide – further enhance its versatility across various procedures.
Solea not only improves patient experiences but also offers practice benefits such as increased productivity, new patient flow, and efficiency gains. In October 2022, Convergent Dental received FDA clearance for Solea to aid in reducing mineral loss in dental enamel, protecting teeth against acid attack and caries development. This breakthrough application was commercially launched in November 2023 under the name Solea Protect.

Convergent Dental

Ossio is an orthopedic fixation technology company that has developed OSSIOfiber Intelligent Bone Regeneration Technology, a breakthrough implant material designed to securely fixate and fully integrate into the body's native anatomy without leaving any permanent hardware behind. This technology addresses the limitations of conventional metal and resorbable implants, combining unparalleled mechanical strength with natural bone healing.
Made from a proprietary mineral fiber matrix held together by a naturally degradable polymer, OSSIOfiber implants provide surgeons with a more biologically friendly way to restore patient stability and mobility. These implants are engineered to provide the strength required for functional fixation while allowing full integration into the native bone without adverse biological response.
Ossio's product portfolio includes compression screws, trimmable fixation nails, hammertoe fixation systems, suture anchors, and compression staples, all made with OSSIOfiber technology. These implants have received multiple FDA clearances since 2019, and the company has initiated commercialization of its products in the US. As of March 2022, over 6,000 implantations of OSSIOfiber products had been performed, demonstrating adoption of this innovative technology.
OSSIOfiber Intelligent Bone Regeneration Technology can address various surgical applications through the manufacturing of implant designs like nails, screws, staples, anchors, and plates. Ossio plans to pursue multiple applications in distal extremities, trauma, sports, reconstruction, pediatrics, and spine segments.
In February 2023, Ossio launched the world's first and only non-permanent compression staple made with OSSIOfiber technology, designed for predictable bone in-growth, regeneration, and replacement.

Ossio

Casana is a healthcare technology company that has developed the Heart Seat, an innovative toilet seat that enables effortless, integrated, and consistent in-home health monitoring. The Heart Seat is a replacement for a standard toilet seat and is designed to measure key clinical parameters such as heart rate, blood oxygen saturation (SpO2), and blood pressure.
In May 2023, Casana received FDA clearance for the Heart Seat to measure heart rate and SpO2 in adults aged 22 years and older, weighing between 90 to 350 pounds. The company plans to file for additional indications, including systolic and diastolic blood pressure, with the goal of launching the product in the market by the end of 2023.
The Heart Seat is equipped with sensors that passively capture health data whenever the seat is used, eliminating the need for user compliance or behavior changes. The data is automatically uploaded to the Casana Cloud, where it can be viewed by healthcare providers, enabling them to monitor patients' health trends and respond to changes in near real-time.
Casana's technology allows for the effortless collection of consistent and reliable data, assisting medical teams in monitoring chronic conditions beyond the hospital or physician's office. The company aims to unlock a new category in healthcare technologies that enables seamless, integrated, and continuous in-home health monitoring.
In January 2022, Casana was acquired by an undisclosed entity, further accelerating the commercialization of the Heart Seat.

Casana

Neurent Medical is a company pioneering innovative non-surgical interventions to treat chronic inflammatory sinonasal diseases, particularly chronic rhinitis. The company's flagship product is the NEUROMARK System, a device that received US Food and Drug Administration (FDA) 510(k) clearance in October 2021.
The NEUROMARK System is designed to gently apply controlled low-power radio frequency (RF) energy to target regions of the nasal cavity, disrupting the parasympathetic nerve signals that can trigger an inflammatory response. This alleviates chronic rhinitis symptoms such as persistent congestion, rhinorrhea (runny nose), swelling of the mucosal membrane, sneezing, and nasal itching. The system's unique flexible leaflet design and proprietary smart algorithms enable precise neurolysis (disruption) of the posterior nasal nerves (PNN) and accessory pathways, accommodating a range of patient anatomies while maintaining mucosal and vascular integrity.
Neurent Medical announced the limited market release of the NEUROMARK System in the US in February 2023, following the establishment of a new Category I Current Procedural Terminology (CPT) code by the American Medical Association (AMA) for PNN procedures, effective January 2024. The American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) also endorsed the PNN procedure in 2023.

Neurent Medical

Genetesis is a medical imaging company specializing in biomagnetic cardiac imaging solutions. It has developed CardioFlux, a flagship magnetocardiography (MCG) system that non-invasively identifies myocardial ischemia, a condition where blood flow to the heart muscle is reduced. The technology measures the magnetic fields generated by the heart's electrical activity to detect ischemia within minutes, without using pharmaceuticals or radiation. CardioFlux MCG is designed to provide advanced imaging while prioritizing patient comfort.
The company's solutions target the diagnosis of coronary microvascular disease (CMD), a condition that has been challenging to identify due to a lack of effective functional diagnostics. By offering an accurate and rapid test for CMD, Genetesis aims to address an unmet clinical need and enable timely management of the condition.
In April 2023, the US Food and Drug Administration (FDA) granted CardioFlux MCG Breakthrough Device designation for the non-invasive diagnosis of myocardial ischemia in patients suspected of having CMD.
Genetesis was founded in 2013 and is headquartered in Mason, Ohio. The company has received over USD 40 million in funding to date, including a USD 17.5 million Series C round in October 2022. In April 2020, TDK Ventures, the corporate venture capital arm of TDK Corporation, invested in Genetesis, providing access to TDK's expertise in areas like biomagnetic sensors and magnetic noise suppression.

Genetesis

Companies that develop diagnostic devices used in a hospital setting to identify a disease, condition, or injury, such as imaging systems and endoscopes

Companies that develop implantable medical devices designed to be surgically placed inside the human body, either temporarily or permanently, including devices such as pacemakers, artificial joints, stents, and cochlear implants

Companies that develop non-surgical devices that are used in a procedure or intervention to cure or relieve a patient from an illness or disease such as laser treatments, dental equipment, and wound care management

Companies that develop monitoring devices that are used in a hospital setting to measure patient vital signs and ensure patient well-being post-treatment, such as cardiac and respiratory monitoring systems

Providers of software that enhances the functionality of medical device hardware (diagnosis, treatment, and monitoring)

Companies that develop surgical devices involving invasive interventions (cutting into a patient's body tissues) to treat, cure, or relieve a patient of an illness or disease

Companies that develop devices to administer pharmaceutical substances into a patient's body, ensuring controlled release or targeted delivery, specifically for use in clinical settings to treat or manage medical conditions effectively

Providers of software that helps manage risks, ensure quality, and streamline audit processes during medical device development

IoT connects devices to EHR systems for precise patient diagnosis and treatment support

Devices are linked to software platforms that use digital technologies such as AI/ML and VR

Startups leverage AI/ML and deep learning to support patient diagnosis and early detection

Intellijoint Surgical

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