Viola Ventures (formerly Carmel Ventures) is a venture capital firm that invests in Israeli-related early stage companies with significant ideas that can lead to transformational companies. Founded in 2000 by [Avi Zeevi](https://www.crunchbase.com/person/avi-zeevi) and [Shlomo Dovrat](https://www.crunchbase.com/person/shlomo-dovrat), Viola Ventures manages over $1.2B across six funds, and is the only Israel-based VC fund with seven investing partners solely dedicated to early-stage tech investments. This allows for unique depth and diversification that spans across a wide range of backgrounds and verticals. With over 20-year legacy in Israel’s vibrant technology ecosystem, Viola Ventures is known for repeatedly backing global tech companies and unicorns, such as ironSource, Payoneer, Lightricks, Redis Labs, and Outbrain. The fund holds a substantial share of Israel’s significant exits, including Actimize, RedBend, ECI, Samanage, Perfecto, Tapingo, and more. Viola Ventures invests in exceptional teams with a strong focus on AI technologies looking to transform traditional markets, the semiconductors and deeptech industries, and consumer facing products.

Viola Ventures

Exor Ventures is the venture capital arm of Exor, one of Europe's largest diversified holding companies. Exor Ventures focuses on early and growth-stage investments in technology-driven companies across various sectors, including digital services, fintech, cybersecurity, and mobility. Exor Ventures leverages its strategic insights and global network to identify promising startups with disruptive potential and supports them through funding, mentorship, and access to its extensive resources.   EXOR Seeds offers a truly different type of partnership to the select group of entrepreneurs that it backs: - As a fifth-generation family-led business, we proved that we are builders not traders; - Our permanent capital allows us to take a long-term view and put the interest of the companies We invest in first; - Our global network, across industries and geographies, is a unique advantage to entrepreneurs

Exor Ventures

LionBird is a Tel Aviv- and Chicago-based venture capital firm investing in early-stage software companies operating in the healthcare, commerce, and enterprise sectors. Founded in 2012, LionBird has developed an investment strategy around early-stage startups that leverages online technology to re-imagine traditional offline business processes and models.

LionBird

GETTY backs era-defining engineering and applied math — from inception to pre-IPO.

GETTY

Inception to Seed — engineering and applied math.

stealth.vc

PhaseV

PhaseV is creating tools and cutting-edge statistical approaches to transform trial design, execution, and analysis. PhaseV recognizes hidden signals in clinical data and extracts actionable insights to help determine the best next moves. The company's technology provides optimal adaptive clinical trial design and closed-loop execution, enhancing efficiency and success rates. PhaseV is developing clinical trial paradigm shifts in order to provide novel therapies to more people in a more precise and efficient manner.

Israel- and Massachusetts-based PhaseV specializes in machine-learning technology that optimizes clinical trial design and analysis. Its platform is also designed to analyze and interpret trial data at any point during ongoing trials to help refine and optimize trials for a closed-loop executive of adaptive trials.

Incorporating technology to improve efficiency and success rate of clinical trials

Clinical Trial Technology

PhaseV to Present Novel Causal Machine Learning Method for Understanding Patient Treatment Response at ML4H Symposium

Quanticate

To create a service focused on streamlining and improving adaptive clinical trials. Through the partnership, Quanticate’s statistical programming, biostatistics, and clinical data management solutions will be used in conjunction with PhaseV's machine learning software.

Companies that provide software tools that help with the design of clinical trials, including identifying protocol violations, collecting participant input on potential design ideas for the trial, and crowdsourcing of protocol ideas for clinical trials

Ørsted

To create a service focused on streamlining and improving adaptive clinical trials. Through the partnership, Quanticate’s statistical programming, biostatistics, and clinical data management solutions will be used in conjunction with PhaseV's machine learning software. 

Israel- and Massachusetts-based PhaseV specializes in machine-learning technology that optimizes clinical trial design and analysis. Its platform is also designed to analyze and interpret trial data at any point during ongoing trials to help refine and optimize trials for a closed-loop executive of adaptive trials.Additionally, PhaseV’s platform can retroactively analyze trial data to create insights from clinical trial data to evaluate endpoints and subpopulations with the aim of identifying new alternate uses for tested drugs. The platform has been used in several clinical trials, including those developing therapeutics in the fields of oncology, endocrinology, autoimmune diseases, and rare diseases. Key customers and partnerships In November 2023, PhaseV partnered with 9xchange, a provider of an ecosystem transaction platform, to provide PhaseV’s clinical trial design and analysis platform on 9xchange’s platform. Through the partnership, 9xchange members, which include life science and biotechnology companies, investors, entrepreneurs, and certain academic centers, will have access to Phase V's proprietary technology. In April 2024, PhaseV partnered with biometric contract research organization Quanticate to create a service focused on streamlining and improving adaptive clinical trials. Through the partnership, Quanticate’s statistical programming, biostatistics, and clinical data management solutions were used in conjunction with PhaseV's machine learning software. The alliance aided in evaluating whether a proposed clinical trial will benefit from an adaptive design, a system that permits changes based on interim results. Funding and financials PhaseV raised USD 15 million in a funding round in October 2023. The round was co-led by Viola Ventures and Exor Ventures, with participation from LionBird and angel investors. The funds were set aside to expand the company’s operations and support product development efforts.

Headquartered in Amsterdam, Castor is a cloud-based e-clinical data platform that can be used for a range of tasks and processes during a clinical trial. It offers four solutions: 1) electronic data capture (EDC) to capture and process data from multiple sources including researchers, 2) electronic patient-reported outcomes (ePRO) to collect and manage patient-reported data on a centralized platform, 3) e-consent - to enable patients to be recruited, screened, and enrolled remotely, and 4) a decentralized clinical trials (DCT) platform to assist operators with managing DCT technologies and devices through a central platform. The company’s solutions are targeted at industries like biotech and pharma, diagnostics, and clinical research organizations. Its solutions are built in line with industry-standard compliance and data protection standards including HIPAA, GDPR, and ISO 27001.Castor aimed to collect enough clinical trial research data to enable the reuse of data for AI-driven clinical trials, which would lower the costs of operating clinical trials and reduce the time taken to bring new drugs to market.Key customers and partnershipsAs of June 2024, the company had supported 14,000+ studies and 6 million patients through clinical trials across 90+ countries, since launching in 2007. In terms of therapeutic areas, Castor had supported a range of different areas, including oncology, cardiovascular diseases, and diabetes. The company had been engaged by 500+ organizations, including the World Health Organization, Click Therapeutics, and Stryker. It was the first to incorporate machine learning into its system for the identification of Covid-19 patients. The company offered free access to its system for Covid-19 research projects, with over 200 projects using the platform as of June 2022. In February 2024, the company partnered with Microsoft to use Microsoft Azure to bring modern AI to clinical trials. The feature was released to help Castor users develop their studies faster by simplifying complex tasks in the study build process. The company additionally noted that it was planning to release its first in a line of Practical AI features to all its users in public Beta. Funding and financialsThe company raised USD 45 million in Series B funding in July 2021, led by Eight Roads Ventures and F-Prime Capital. The funds were earmarked for product development, interoperability with partner systems, and market research on decentralized trials. The company had a headcount of 150 at the time of the Series B and was planning to expand to 200 by the end of 2021.

Castor

Florence Healthcare offers a platform for clinical trial management. It has four key components: 1) SiteLink to start-up and monitor remote clinical sites, 2) eBinders to digitize and store research binders, 3) eConsent to simplify and digitize the consent process, and 4) Electronic Trial Master File to digitize the storage and transfer of files between sites and research sponsors. The platform is compliant with standard industry requirements including HIPAA, 21 C.F.R Part 11, ICF/GCP, and GDPR.Key customers and partnershipsAs of June 2024, Florence supported over 18,000 research sites, across 55+ countries, with key customers including Pfizer. The usage of the company’s software tripled in 2020, driven by an industry shift toward digitalization as a result of the Covid-19 pandemic. In February 2022, the company was ranked as the best clinical trial platform out of a group of 190 for ease of setup, ease of use, and customer support.Florence partnered with Greenphire, a company focusing on patient convenience and financial management for clinical trials, in Janauary 2024. Through the partnership, Florence's platform will be integrated with Greenphire's to improve payment systems within clinical trials. Benefits of the partnership included reduced manual work for sites, faster payments, and better visibility of site activity for sponsors and Contract Research Organizations (CROs). Funding and financialsThe company raised USD 80 million in Series C funding in May 2021 led by Insight Partners. The proceeds were to be used to scale up its sales and marketing teams and improve the value proposition of the platform by reducing the time required by customers to implement and manage clinical trials.

Florence Healthcare

Huma is a UK- and US-based clinical trial tech startup that provides a digital platform to manage clinical trials, including decentralized clinical trials. The platform can be used throughout the clinical trial process, including patient recruitment, screening, electronic consent, clinical outcome assessments, patient-reported outcomes, and telemedicine. The platform is built up to industry standards in data privacy and security, including ISO 27001, 21 C.F.R. Part 11, and TxP.In June 2023, the company <a href="https://sp-edge.com/updates/19352">received FDA 510(k) Class II FDA clearance </a>for its configurable disease-agnostic platform, including its cardiovascular risk score algorithm. The company received this FDA clearance in partnership with Health Canada and it allows Huma's platform to be used to monitor patients of all ages with any condition, including pediatrics and pregnancy. The Class II clearance also enables the platform to host algorithms that provide automated AI-driven data analytics for diagnosis, screening, clinical decision-making, predictions on health outcomes, and recommendations on dosage.In July 2024, the company was <a href="https://sp-edge.com/updates/31552">estimated to be valued at nearly USD 1 billion</a> when it secured a Series D investment of USD 80 million. Key customers and partnershipsSome of the key partners working with Huma include AstraZeneca, Johnson &amp; Johnson, Bayer, Stanford University, and the University of Cambridge. As of July 2024, the platform supported 3,000+ hospitals and clinics, screened over 35 million individuals, and had 1.8 million active users across 70 countries. Huma was awarded the 2021 Prix Galien Award, which is widely considered the “Nobel Prize” for pharmaceuticals and life sciences.The company announced a partnership with Xyla Elective Care in June 2022, to provide support to the UK’s National Health Service in delivering and managing virtual wards.

Huma

Based in California and founded in 2015, Medable is a digital clinical trial management platform with a range of modules for different processes. These modules include a decentralized clinical trial platform to support decentralized trials using remote tools for data gathering, monitoring, televisits, and consent; digital patient screening to screen patients remotely and at scale; e-consent to enable patients to digitally consent for clinical trials; electronic clinical outcome assessments; and patient-reported outcomes to document data in real time and provide easy access for researchers. It also includes remote patient monitoring to make it easy for patients to record and share data with clinical research teams.Medable operates on a SaaS business model, with customers having the option of selecting and deploying only the modules required as part of their uniquely customized solution.In <a href="https://sp-edge.com/updates/32647">August 2024</a>, Medable launched 'Medable Studio', an all-in-one application for configuring, translating, validating, and launching electronic clinical outcome assessment (eCOA) Plus solutions (which include eCOA, e-consent, televisits, and sensors) into clinical trials. The no-code suite aimed to simplify the complex eCOA launch process, offering biopharmaceutical companies greater control and transparency. Medable Studio includesda point-and-click builder for creating assessments and instruments, a visual schedule of assessments builder, a translation workbench, and a content library. The platform enabled users to rapidly build and launch complex clinical trials, with the ability to create protocol-fit study designs in hours instead of months.In <a href="https://sp-edge.com/updates/35913">November 2024</a>, Medable launched Medable AI, a suite of GenAI capabilities integrated into its Studio platform. The suite aimed to streamline digital and decentralized clinical trials for sponsors and research organizations. The AI suite features automated eCOA creation that converts existing outcome assessments into a digital format, a ChatGPT-like interface for editing assessments, and scalable assessment-generation capabilities.&nbsp;As of <a href="https://hitconsultant.net/2024/10/30/medable-partners-with-google-cloud-to-accelerate-clinical-trials/">October 2024</a>, the company offered its platforms across 60 countries and was used across 300 decentralized and hybrid clinical trials. The company’s platform is compliant with industry standards, including HIPAA, FDA’s 21 CFR Part 11, and GDPR.Key customers and partnershipsAs of <a href="https://www.businesswire.com/news/home/20240607926468/en/Medable-Wins-2024-Prix-Galien-UK-Award-for-Best-Digital-Health-Solution">June 2024</a>, Medable claimed to work with 14 out of the top 20 pharmaceutical companies, in addition to working with a range of partners, including Cognizant, Accenture, Oracle, and PwC.In <a href="https://sp-edge.com/updates/35456">October 2024</a>, the company partnered with Google Cloud to offer its decentralized clinical trial platform on Google Cloud's marketplace. The collaboration combined Medable's clinical trial technology with Google Cloud's infrastructure and AI capabilities to streamline trial processes.In <a href="https://sp-edge.com/updates/29843">May 2024</a>, Medable partnered with Masimo, a medical technology provider, to incorporate new wearable devices in clinical research. Medable announced it would include the MightySat Rx pulse oximeter by Masimo in its platform for various major clinical trials, particularly in lung and breast cancer research.In <a href="https://sp-edge.com/updates/22394">October 2023</a>, the company partnered with Pluto Health, a healthcare coordination company, to enhance the clinical trial experience for participants and improve data collection during trials. Through the partnership, the companies aimed to connect patients to the right medical resources including access to clinical trials and home delivery of medication.&nbsp;In <a href="https://www.fiercebiotech.com/biotech/gsk-taps-medable-decentralized-clinical-trials-patient-diversity">September 2022</a>, the company announced a four year agreement with GlaxoSmithKline to use Medable’s platform for clinical trials across multiple products. Financial terms of the agreement were not disclosed.

Medable

Headquartered in New York, Obvio Health provides a full service for clients, supporting them throughout the clinical trial process from the design and recruitment stages to outcome measurement and reporting. In addition to its technological platform, the company provides professional services to execute clinical trials using its in-house clinical operations team. The platform caters to 17 therapeutic areas, including cardiology, oncology, respiratory, men's and women's health, dermatology, gi, hepatology, mental health, oral health, and infectious disease (Covid-19). The platform is compliant with industry standards including 21 CFR Part 11, ICH-GDP, GDPR, and ISO 27001.According to the company, its platform was designed from the ground up to cater to digital trials run by virtual clinical teams, which resulted in faster patient recruitment (three months for Obvio compared to 12 months for physical site trials). In January 2022, the company launched an augmented electronic patient-reported outcome (augmented ePRO) module, which incorporates AI and manual scoring by experts/clinicians. The company claims this improves the accuracy and quality of data collected.In April 2024, the ObvioHealth launched ObvioGo 2.0, an enhanced platform and mobile application designed to meet the unique needs of trial sites and sponsors. The upgraded platform allows the combination of hybrid and virtual trial designs within one study. It includes features such as the ability to create site-specific workflows, integration with other clinical systems, and a streamlined translation process. Additional features include a built-in virtual assistance team, COACH, for trial tasks support and a patient identifier tool for patient registration and data correlation.As of June 2024, the platform catered to 17 therapeutic areas, including cardiology, oncology, respiratory, men's and women's health, dermatology, GI, hepatology, mental health, oral health, and infectious disease (Covid-19). The platform is compliant with industry standards including 21 CFR Part 11, ICH-GDP, GDPR, and ISO 27001.Key customers and partnershipsAs of June 2024, Obvio Health’s client base included companies like GlaxoSmithKline, Pfizer, Bayer, Danone, and General Mills. As of June 2024, the company’s operations were spread over 28 countries and had supported obtaining consent from 40,000+ patients across 40 clinical trials since its launch.In March 2022, Obvio partnered with Renovia to conduct the first fully virtual trial in urogynaecology, based on Renovia’s Leva device. The device helped patients with performing kegel exercises more effectively, in addition to monitoring compliance over the trial period.In November 2023, Obvio then partnered with Chemist Warehouse, the largest retail pharmacy chain in Australia, to improve the reach and efficiency of clinical trials. Through the partnership, Chemist Warehouse agreed to promote ObvioHealth-managed trials to its customers in Australia, using both offline and online channels. Additionally, ObvioHealth agreed to utilize Chemist Warehouse's Telehealth services for studies that require clinician assessments. The collaboration aimed to increase the awareness and convenience of clinical trials, addressing two major hurdles in participant recruitment. The long-term goal of the partnership was to expedite the introduction of innovative therapies to the market more efficiently and economically.&nbsp;

Obvio Health

Companies offering data and workflow management platforms and solutions to assist with the operational management of a clinical trial, including site management, monitoring processes in terms of risk and documentation, and payment automation

Companies using remote patient monitoring tools and other connectivity solutions to enable remote collection of patient data and monitoring and run trials virtually without requiring the patient to be physically present at the clinical trial site

Companies that offer workflow management platforms that are used to manage logistics tasks and processes for clinical trials, primarily the randomization of assigning patients in a clinical trial and automation of logistics workflows based on clinical trial data

This is the use of software, incorporating AI and machine learning technology to improve the matching process of patients with suitable clinical trials

Companies that offer software solutions for identifying and evaluating potential trial sites, along with documentation and workflow management systems to complete the processes before launching, including electronic patient consent and other required regulatory tasks

Includes companies that provide digital data management platforms to collect and store patient reported outcome data. These platforms are also incorporating data analytics to help understand the results and identify trends and patterns. Additionally, the platforms enable connectivity with remote monitoring devices, including the Medical Internet of Things

Companies that use GenAI as a core part of their product offering for Clinical Trial Tech

Startups in this hub use IoT to support report patient monitoring and data gathering

AI/ML algorithms can be used to automate the analysis of patient data

Offers digital platforms that accelerate clinical trials and evaluations

Most CTT platforms are offered on a B2B basis to companies carrying out clinical trials

Startups in this hub seek to improve clinical trial diversity by including underrepresented communities

Clinical Trial Technology providers incorporate GenAI to enhance their platform’s capabilities and utility

PROMINENT_CATEGORY

<div>
 
 PhaseV, a firm specializing in optimizing clinical trial design and analysis, has formed a partnership with Quanticate, a biometric contract research organization. The collaboration is aimed at enhancing the efficacy of adaptive clinical trials.
 The partnership will amalgamate Quanticate’s expertise in statistical programming, biostatistics, and clinical data management with PhaseV's machine learning software. The objective is to assess the applicability of an adaptive design in a proposed clinical trial, which allows modifications based on interim outcomes. The collaboration is aimed at resolving the difficulties encountered by sponsors in implementing adaptive trial designs effectively. Quanticate will be at the forefront in optimizing the trial design and management after determining its suitability.
 
</div>

PhaseV

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