Twelve Below operates as a venture capital firm.

Twelve Below

Lerer Hippeau is a seed-stage venture capital firm founded and operated in New York City. Since 2010, they have invested in entrepreneurs with great ideas who aren’t afraid to do hard things. Their portfolio includes more than 400 enterprise and consumer businesses including Guideline, MIRROR, Blockdaemon, K Health, Allbirds, ZenBusiness, and Thrive. They’re experienced operators who invest early and stay in their founders’ corners as they build iconic companies.

Lerer Hippeau

Collaborative Fund is an investment fund that provides funding to companies based on creativity and collaborative consumption. The fund centers around two macro themes which drives business innovation in the coming years: the growth of the creative class and the concept of collaborative consumption. Craig Shapiro founded it in New York in 2010.

Collaborative Fund

Wireframe Ventures is a venture capital firm investing at the seed and pre-seed stage. We back missionary founders using technology to positively impact people & planet.

Wireframe Ventures

Factorial Capital

Ritual Capital is a seed-stage venture fund that invests in creators creating iconic brands.

Ritual Capital

Caladan Bio

Caladan Bio specializes in next-generation bioreactors, offering modular, affordable, and cutting-edge solutions.

Caladan Bio is a biotechnology company that specializes in the development of benchtop bioreactor systems. These systems offer modular and cost-effective solutions for various synbio applications and are claimed to be fully automated with high throughput. Moreover, it comes integrated with control software and a suite of sensors for real-time monitoring, analysis, and data collection.

Making meat sustainable over the long term

Cell-cultured Meat

Caladan Bio on LinkedIn: Caladan Bio raises $5m seed round to build next generation benchtop…

Caladan Bio is a biotechnology company that specializes in the development of benchtop bioreactor systems. These systems offer modular and cost-effective solutions for various synbio applications and are claimed to be fully automated with high throughput. Moreover, it comes integrated with control software and a suite of sensors for real-time monitoring, analysis, and data collection.Caladan’s first product, the Caladan 250, is a modular 250 ml bioreactor featuring enhanced sensors and integrations for AI and ML tools.Funding and financialsIn <a href="https://sp-edge.com/updates/29009">May 2024</a>, the company raised USD 5 million in seed funding led by Twelve Below, with participation from Lerer Hippeau, Collaborative Fund, and others. The funds were earmarked for team expansions and enhancing the platform.

Mosa Meat is a Dutch cell-cultured meat startup founded by Dr. Mark Post of Maastricht University, and was the first-ever company to produce a lab-grown meat burger. The startup produces meat by growing myosatellite cells (muscle stem cells) extracted from an animal in a bioreactor fed with a nutrient-dense medium.The company replaced the fetal bovine serum (FBS) from its growth medium in July 2020, which led to an 88x cost reduction in its medium. As of March 2024, Mosa Meat operated the Center for Advanced Meat Production, Upscaling, and Sustainability (CAMPUS), a facility spanning over 79,000 sq ft that was designed to be expandable as demand grows.In <a href="https://sp-edge.com/updates/21645">September 2023</a>, Mosa Meat became the first cultivated meat company to attain B Corp certification. The company also announced plans to apply for regulatory approval in countries worldwide. In <a href="https://sp-edge.com/updates/21645">September 2023</a>, Mosa Meat became the first cultivated meat company to attain B Corp certification. The company also announced plans to apply for regulatory approval in countries worldwide. In <a href="https://sp-edge.com/updates/31970">July 2024</a>, it conducted the first official tasting of its cultivated beef product, the Mosa Burger, in the Netherlands. This event gathered Dutch cattle farmers, food product developers, and industry representatives to collect expert feedback.Key customers and partnershipsIn <a href="https://sp-edge.com/updates/14175">November 2022</a>, Mosa Meat entered into an agreement with Singapore-based contract development and manufacturing organization (CDMO) Esco Aster to commercialize its cultivated beef in Singapore. Further, in <a href="https://sp-edge.com/updates/16845">March 2023</a>, the company partnered withNutreco to develop a cell feed supply chain that can expedite production and scalability while reducing cost.Funding and financialsIn its latest funding round in <a href="https://sp-edge.com/updates/28536">April 2024</a>, the company raised EUR 40 million (~USD 42.5 million) in an oversubscribed funding round co-led by Lowercarbon Capital and M Ventures, with participation from PHW Group, Invest-NL, LIOF, and LEF. The funds were earmarked for scaling production procedures, reducing production costs, and gearing up for commercialization.

Mosa Meat

SuperMeat is a cellular agriculture startup developing cultured chicken meat. The company uses chicken cells and claims to grow them in a culture medium free from antibiotics and contaminants to develop its products. SuperMeat also operates a test kitchen known as The Chicken. It is claimed to be the world’s first farm-to-fork facility where diners can observe the production of cultivated chicken.In <a href="https://sp-edge.com/updates/21733">September 2023</a>, The Orthodox Union (OU) certified SuperMeat’s cultivated chicken as “kosher.” Further, the OU and SuperMeat will collaborate on establishing guidelines for the industry.In&nbsp;<a href="https://sp-edge.com/updates/35765">November 2024</a>, the company announced it had achieved cost parity for its cultivated chicken and could produce it at at USD 11.79 per pound at scale, matching the price of premium US pasture-raised chicken.Key customers and partnershipsIn <a href="https://sp-edge.com/updates/9319">March 2022</a>, SuperMeat signed an MoU with PHW to supply cultivated meat products including chicken, turkey, and duck to the European market. The company also <a href="https://sp-edge.com/updates/8997">partnered</a> with Ajinomoto to set up a joint venture to accelerate the commercialization of cultivated meat while focusing on developing a cost-competitive cell growth media.In <a href="https://sp-edge.com/updates/11867">July 2022</a>, the company signed an MoU with Switzerland’s largest retail supermarket chain and leading meat manufacturer, Migros to expedite production and distribution of cultured meat at a commercial scale with a focus on European markets.&nbsp;

SuperMeat

Uncommon (formerly HigherSteaks) is a UK-based cell-cultured meat startup that uses cellular agriculture to grow pork from animal cells. The company leverages cellular agriculture and in-house developed RNA technologies to cultivate meat and claims its technology eliminates the need for genetic engineering and growth media.In July 2020, the company unveiled the world's first lab-grown pork belly prototype and the second cell-based bacon (behind Mission Barns cell-based bacon unveiled in early 2020). The pork belly and the bacon were produced from a combination of cell-cultured muscle and plant-based proteins and fat. Uncommon plans to commercialize its cell-cultured meat by 2022-2025, pending regulatory approval.Funding and financialsIn <a href="https://sp-edge.com/updates/19267">June 2023</a>, the company raised USD 30 million in Series A funding co-led by Balderton Capital and Lower Carbon Capital, with participation from Redalpine, East Alpha, and others. The funds were earmarked for the development of its innovative approach, expanding production, increasing the team, and initiating regulatory approvals.

Uncommon

Multus, a spin-off of SOSV’s IndieBio program, is a biotechnology company that specializes in the development of growth media solutions for cellular agriculture applications. Its portfolio includes serum-free FBS alternatives (Proliferum M and Proliferum LSR) and solutions that support cell adhesion (rh-Vitronectin) during the cultivation process.Multus leverages MediOp, a growth media formulation design platform, to develop its solutions. According to the company, this technology allows optimizing solutions using automated data analysis and insights. Multus also uses this platform to provide contract manufacturing services for custom formulation design and food-safe manufacturing compliant with ISO22000 to customers in North America, Europe, and Asia-Pacific. In December 2024, the company launched&nbsp;<a href="https://sp-edge.com/updates/37120">Proliferum B</a>, an animal component-free alternative to fetal bovine serum (FBS) for cultivated meat production.In <a href="https://sp-edge.com/updates/25572">January 2024</a>, the company unveiled what it claims to be the first large-scale production plant-making serum-free growth media in the cultivated meat industry.Key customers and partnershipsIn <a href="https://sp-edge.com/updates/24911">December 2023</a>, the company partnered with New Wave Biotech, a bioprocess optimization software company, under a project funded through an Innovate UK Engineering Biology grant. Through this partnership, Multus planned to use New Wave Biotech’s AI software to optimize its process of developing precision-fermented ingredients for cell cultivation.&nbsp;

Multus

Based in Israel, Believer Meats (Future Meat Technologies prior to November 2022) develops hardware and cell lines for the manufacturing of cell-cultured meat, to commercialize its manufacturing hardware and techniques.Believer Meats uses fibroblast cells that can be triggered with small molecules to develop either fat or muscle cells. Fat and muscle cells are cultured in a unique bioreactor that removes the waste material from the media, allowing the company to recycle parts of the media to reduce feed media input by as much as 50%. The startup replaced FBS with molecules derived from Chinese hamster ovaries (CHO) to reduce production costs and plans to achieve price parity with animal counterparts.In <a href="https://sp-edge.com/updates/12623">August 2022</a>, the company announced it has developed what it claims to be the world’s first cultivated lamb, using cell lines isolated from Awassi sheep.In <a href="https://sp-edge.com/updates/15195">December 2022</a>, the company announced it has begun development of a 200,000 sq foot production facility in Wilson, North Carolina with an annual capacity of ~22 million lbs, which is claimed to be the largest cultivation facility in the world. Believer Meats plans to produce cultured chicken, pork, beef, and lamb for US, European, and Asian markets.Key customers and partnershipsIn March 2022, the company <a href="https://sp-edge.com/updates/9320">partnered</a> with Charoen Pokphand Foods to develop cultivated meat products for Asia.In <a href="https://sp-edge.com/updates/17710">April 2023</a>, Believer Meats signed an MoU with Archer Daniels Midland (ADM) to collaborate on the development and commercialization of cultivated meat products. Further, ADM will offer its ingredient pantry and nutrition knowledge to enhance Believer's cell-cultivated meat process.In <a href="https://sp-edge.com/updates/30520">June 2024,</a> Believer Meats partnered with Abu Dhabi’s AgriFood Growth &amp; Water Abundance (AGWA), to advance cultivated meat production in the MENA region.&nbsp;&nbsp;

Believer Meats

Producers of cell-cultured seafood using cells extracted from fish. Startups have succeeded in developing prototypes of yellowtail and salmon

Producers of cell-cultured pork using cells extracted from animals. Startups have succeeded in developing prototypes of bacon and pork belly using cultured muscle and plant-based proteins and fat

Producers of cell-cultured beef using cells extracted from animals. Some producers in the industry are developing premium beef ranges such as Wagyu. Startups have only succeeded in developing prototypes in the minced form, with a few creating prototypes of (pieces of) steak using 3D bioprinters

Producers of cell-cultured chicken and duck using cells extracted from animals. Some producers in the industry are developing rare delicacies such as foie gras. Startups have only succeeded in developing products in the nugget form

Producers of growth media for cell-cultured meat production and ingredients for meat and meat analog (cell-cultured, plant-based) producers, which can include cell culture meat paste, culture fat, etc. Producers of growth media mainly focus on developing alternative growth media to FBS using plant-based or other sources

Developers of bioreactors and other technologies used in cell-cultured meat production. Industrial scaling and efficiency gains are key areas of interest for startups in the industry

Provide sustainable solutions for animal slaughter through the use of biotechnology

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 Caladan Bio, a startup specializing in bioreactor systems, has successfully raised $5 million in seed funding. The funding round was led by Twelve Below, and included contributions from Lerer Hippeau, Collaborative Fund, Wireframe Ventures, Ritual Capital, and Factorial Capital.
 The funds are set to be used for expanding the company's team and enhancing the company's bioreactor platform. As part of future plans, the startup is looking to establish pilot partnerships for installations within the second half of 2024.
 Founded in 2023, Caladan Bio's main product is the Caladan 250, a 250 ml modular bioreactor. The company's innovative systems aim to decrease the costs involved in experimentation for synbio companies, while also increasing the amount of data produced from these experiments. As a unique feature, the Caladan 250 has enhanced sensors and is integrated with AI and ML tools.
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Caladan Bio

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