Y Combinator is a startup accelerator that provides funding and mentorship to early-stage companies. It offers a program where startups receive guidance from experienced entrepreneurs and investors. The organization helps founders in their business models and develop their products. Y Combinator serves industries such as technology, healthcare, and finance.

Y Combinator

CoreNest is a powerhouse for nurturing and funding startups in cutting-edge sectors like AI, Blockchain, and Fintech. With a commitment to shaping a bright future of innovation, CoreNest provides more than just funding. It offers a complete support system, ensuring every new venture grows and thrives. From the early stages to full-fledged growth, startups receive personalized assistance and strategic investment opportunities. At CoreNest, it's not just about funding startups; it’s about ensuring shared growth and helping every innovative idea rise to its peak of success and impact.

CoreNest Capital

Early-stage: backing the daring — building the mighty.

10 BOND

Lionheart Ventures is a global, seed-stage venture capital firm focused on mitigating civilizational risk. We do this by supporting the wise development of transformative technologies. Our main areas of investment focus are transformative artificial intelligence and frontier mental health technologies. Leading academics estimate a 1-in-6 chance of human extinction by the year 2100, largely driven by risks from emerging technologies. And now, with the exponential growth of AI, predictions are getting worse. Our startups are part of the solution. We invest in exceptional, ethical founders who are developing transformative technologies that have the potential to impact humanity on a meaningful scale, while generating attractive returns for our LPs.

Lionheart Ventures

Adverb Ventures is a new venture capital firm.

Adverb Ventures

Piramidal

Piramidal offers artificial intelligence software that transforms brain activity into easy-to-understand health data to help diagnose neurological diseases.

Piramidal is a startup founded by Dimitris Fotis Sakellariou and Kris Pahaju, backed by Y Combinator (YC). The company has developed a foundational artificial intelligence (AI) model designed to understand and detect brain activity for instant diagnosis of neurological conditions. This model is trained on a massive and diverse dataset of brainwaves, which Piramidal refers to as "brain language," similar to how large language models (LLMs) work with human language.

Piramidal’s Foundational AI Brain Model for Neurology Diagnostics

Bridging the gap between the human brain and computer

Brain-computer Interfaces

Piramidal is a startup founded by Dimitris Fotis Sakellariou and Kris Pahaju, backed by Y Combinator (YC). The company has developed a foundational artificial intelligence (AI) model designed to understand and detect brain activity for instant diagnosis of neurological conditions. This model is trained on a massive and diverse dataset of brainwaves, which Piramidal refers to as "brain language," similar to how large language models (LLMs) work with human language.
Piramidal's AI model aims to address the widespread shortage of neurologists in the US and the inefficiencies associated with the manual review process of electroencephalograms (EEGs), which are crucial tests for diagnosing neurological disorders. The company claims that its brain foundation AI model can diagnose a vast majority of neurological conditions swiftly, reducing the time wasted on manually analyzing EEG data.
Beyond diagnostics, Piramidal's model is also intended to be useful in drug and biomarker discovery for clinical trials, as well as remote monitoring of brain abnormalities for generating treatment for less critical neurological illnesses or disorders, such as sleep irregularities. The model is designed to accommodate modern technology, enabling real-time brain health tracking using helmets for monitoring cognition or head injuries, with potential applications in sports and the military. Additionally, the brain AI model can translate brain signals into everyday actions through virtual reality (VR) technology like Apple Vision Pro and Meta Quest.
Piramidal's first and only product as of March 2024 is a copilot for epilepsy diagnosis powered by its brain model. This product aims to assist neurologists in obtaining diagnostic insights in real-time, reducing the time required to review patients' EEGs from hours to seconds. The startup claims that the copilot will standardize EEG analysis, reducing error margins, misdiagnoses, and recurrent hospital visits.

Neuralink is a neurotechnology company founded by Elon Musk with the goal of developing brain-computer interfaces (BCIs). The company's flagship product is the N1 Implant, a coin-sized device that is surgically implanted in the brain. The implant contains 1,024 electrodes distributed across 64 ultra-thin threads that can monitor neural activity and electrically stimulate the brain. It wirelessly transmits brain data to external devices, allowing users to control computers or mobile devices directly with their thoughts.
Neuralink's initial focus is on providing digital freedom for people with quadriplegia by enabling them to interact with technology using neural signals. The N1 Implant will be placed in the motor cortex region of the brain that controls movement intention. As of March 2024, Neuralink has implanted its device in at least one human participant, allowing them to control a computer mouse cursor and play video games purely by thinking.
The implant surgery is performed using a custom robotic system developed by Neuralink. This surgical robot automatically inserts the electrode threads into the desired brain region with high precision. Neuralink claims the robotic implantation process aims to be as minimally invasive as procedures like LASIK eye surgery.
Key customers and partnerships
In November 2023, Neuralink announced its first clinical trial, dubbed the "Prime Study," to evaluate the N1 Implant's safety and functionality in human participants with quadriplegia caused by cervical spinal cord injury or amyotrophic lateral sclerosis (ALS). The study is expected to enroll participants aged 22 and older over a period of six years.
Neuralink has previously collaborated with the University of California, Davis to conduct animal testing of its brain implants on monkeys and other research animals. However, this partnership ended in 2020 amid allegations from an animal rights group regarding the treatment of monkeys during experiments.

Neuralink

Kernel is a neurotechnology company developing non-invasive brain imaging devices. Their flagship product, Kernel Flow, is a wearable headset that uses time-domain functional near-infrared spectroscopy (TD-fNIRS) technology to measure brain activity. Kernel Flow emits near-infrared light and detects changes in blood oxygenation levels in the brain's cortical areas, similar to functional magnetic resonance imaging (fMRI). However, it offers advantages such as portability, affordability, and the ability to measure brain activity in natural environments.
Kernel Flow features 52 modules arranged in four plates that fit on either side of the head. Each module contains two laser sources that generate picosecond pulses of light and six detectors that capture the reflected light. By recording the photon arrival times, the system can measure changes in oxyhemoglobin and deoxyhemoglobin concentrations, providing insights into brain function.
Kernel has conducted studies demonstrating the efficacy of Kernel Flow in various applications, including measuring the psychedelic effects of ketamine, predicting gaming expertise, and assessing cognitive decline. As of January 2022, the company had provided 50 systems to partners for evaluation and launched commercial sales for research teams.

Kernel

Synchron is a neurotechnology company developing an implantable brain-computer interface (BCI) system designed to enable patients with severe paralysis to wirelessly control digital devices through their thoughts and improve functional independence. Their flagship technology, the Stentrode, is an endovascular brain implant that is inserted into the brain's motor cortex via the jugular vein using a minimally invasive endovascular procedure, eliminating the need for open brain surgery.
The Stentrode contains electrodes that detect motor intent signals from the brain, which are wirelessly transmitted to an external device. Using machine learning algorithms and signal processing techniques, these neural signals are then translated into digital commands, allowing the user to control personal devices like computers and smartphones for tasks such as texting, emailing, online shopping, and accessing telehealth services.
In August 2020, Synchron received FDA Breakthrough Device designation, followed by the first Investigational Device Exemption (IDE) in July 2021 for evaluating a permanently implanted BCI. The company has conducted clinical trials in Australia and the US, with the first US implantation occurring in July 2022 at Mount Sinai Health System in New York. As of January 2023, Synchron reported that the Stentrode remained safe and functional in four Australian patients after 12 months, with no serious adverse events or significant signal deterioration.

Synchron

Paradromics is an Austin, Texas-based neurotechnology company developing a high data-rate brain-computer interface (BCI) called the Connexus Direct Data Interface (DDI). The Connexus DDI is designed to collect an unprecedented number of individual neural signals from the brain using a fully implantable device intended for long-term daily use.
The first application of the Connexus DDI is an assistive communication device that translates brain signals into speech and movement in real-time. This revolutionary technology aims to restore the ability to communicate and interact with technology independently for people with conditions like ALS, spinal cord injuries, and stroke that cause severe motor impairment.
In May 2023, Paradromics raised USD 33 million in a Series A funding round led by Prime Movers Lab, with participation from Westcott Investment Group, Dolby Family Ventures, and Green Sands Equity. This investment will enable the company to launch its first-in-human clinical trial for the Connexus DDI.
Additionally, in a significant milestone, the US Food and Drug Administration (FDA) granted the Connexus DDI a Breakthrough Device Designation in May 2023. This designation recognizes the transformative potential of the device and allows for an expedited review process, accelerating its availability to patients.

Paradromics

Cognixion is a leading developer of non-invasive Brain-Computer Interface (BCI) and Augmented Reality (AR) technology. Their flagship product, the Cognixion ONE Axon, utilizes electroencephalogram (EEG) technology to provide a non-invasive brain-computer interface. It enables patients with advanced disease progression, such as Amyotrophic Lateral Sclerosis (ALS), Motor Neuron Disease (MND), traumatic injuries, and cerebral palsy, to communicate their responses with their thoughts and mental attention in a wearable, augmented reality headset.
The Cognixion ONE Axon integrates Artificial Intelligence (AI), including GPT large language models, to rapidly support the user's communication intentions and desired outcomes. It provides contextual predictions and suggestions that can be quickly selected and communicated audibly and visually on the front visor as a communication aid. The device aims to become the first FDA-cleared device allowing fully paralyzed or locked-in patients to communicate via a non-invasive brain-computer interface once eye-tracking is no longer usable due to ocular motor decline.
Cognixion's technology combines AI, Augmented Reality, and Assistive Technology, designed to help people with severe motor impairments communicate and interact more effectively and independently with the world around them. Unlike invasive BCI technologies, Cognixion's device can be prescribed and utilized without surgical procedures or significant training, providing a new level of independence and autonomy.
Key customers and partnerships
In May 2023, the Cognixion ONE Axon received US Food and Drug Administration (FDA) Breakthrough Device designation, which will streamline its development and validation process with prioritized feedback from FDA review staff. This designation is awarded to devices that demonstrate the potential to provide more effective treatment for life-threatening or debilitating conditions where no clear alternatives exist.

Cognixion

Non-invasive hardware typically involving wearable devices that can record, monitor and interact with brain activity using methods like electroencephalography (EEG), enabling the control of prosthetic limbs, operating computers, and more

Physical devices implanted in the body, often in the brain, to interface with neural signals such as electrodes or neural implants

Companies that offer software platforms for BCI applications, including cloud platforms that enables neural data storage

Companies that gather, store, analyze, and interpret neural data collected via BCIs in order to generate valuable insights for clinical decision making

Most BCI companies personalize the BCI devices based on the patient's condition and goals

Most BCI companies leverage a digital means of extracting and interpreting neural data, some of which use mobile applications to provide insights

The products/platforms offered by most companies utilize AI/ML in enhancing their offering

Piramidal

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