Cascade Investment Group offers clients personal, custom investment advice, and solutions. Cascade Investment Group is a team of investment professionals, with over 100 years of combined investment experience, who have established an investment firm that puts the interests of the client and investment manager on the same side of the table. When asked to define their basic philosophy, the following statement best describes what we believe: An investment portfolio is as individual as every client is. It should be designed to complement the client's particular needs and objectives, whatever they may be. Criteria for the safety of principal, current income, growth of capital, and total return should be what directs and controls the management of all investment assets.

Cascade Investment

The Bill & Melinda Gates Foundation is a grant-making foundation that supports initiatives in education, world health and population, and community giving in the Pacific Northwest. In its local region, the foundation promotes strategies and programs that help low income families.The Bill & Melinda Gates Foundation was co-founded by Bill Gates and Melinda Gates in 2000 and is based in Seattle, Washington, with regional offices in Washington, D.C.; New Delhi, India; Beijing, China; and London, United Kingdom. Its trustees are Bill and Melinda Gates, and Warren Buffett.

Bill & Melinda Gates Foundation

WuXi AppTec provides a broad portfolio of R&D and manufacturing services that enable companies in the pharmaceutical, biotech and medical device industries worldwide to advance discoveries and deliver groundbreaking treatments to patients. As an innovation-driven and customer-focused company, WuXi AppTec helps our partners improve the productivity of advancing healthcare products through cost-effective and efficient solutions,With industry-leading capabilities such as R&D and manufacturing for small molecule drugs, cell and gene therapies, and testing for medical devices, WuXi AppTec's open-access platform is enabling more than 3,900 collaborators from over 30 countries to improve the health of those in need – and to realize our vision that ''every drug can be made and every disease can be treated''.

WuXi AppTec

Founded in 2006, Qiming Venture Partners is a leading China venture capital firm with offices in Shanghai, Beijing, Suzhou, Hong Kong in China, and Singapore. Currently, Qiming Venture Partners manages eleven US Dollar funds and seven RMB funds with $9.5 billion in capital raised. Since our establishment, we have invested in outstanding companies in the Technology and Consumer (T&C) and Healthcare industries at the early and growth stages. Since our debut, we have backed over 530 fast-growing and innovative companies. Over 200 of our portfolio companies have achieved exits through IPOs at the NYSE, NASDAQ, HKEX, Shanghai Stock Exchange, or Shenzhen Stock Exchange, or through M&A or other means. There are also over 70 portfolio companies that have achieved unicorn or super unicorn status.

Qiming Venture Partners

Google Ventures invests in sectors including life sciences, consumer, enterprise, crypto, climate, and frontier technology. With Alphabet as its sole limited partner, Google Ventures focuses on long-term investments. Its operating partners assist startups in design, equity, diversity & inclusion, talent, and engineering and help them connect with Google for technology and expertise. Founded in 2009 as Google Ventures, Google Ventures manages over $8 billion in assets with 400 active portfolio companies in North America and Europe. Some notable investments include Uber, Nest, Slack, GitLab, and One Medical. Google Ventures is based in the San Francisco Bay Area with offices in Cambridge, New York, and London.

Google Ventures

Deerfield is an investment management firm. They provide a healthcare ecosystem through information and investment. They also provide private and public investments across the life science, medical device, diagnostic, digital health, and health service industries.

Deerfield

Our primary purpose as an organization is to deliver high quality financial investment services and products. We will continue to be known as the firm where personal attention will never become obsolete. We want to employ people who are extremely satisfied and who go the extra mile for clients. We want a culture of growth, profitability and enthusiasm throughout the firm.

Baron Capital Management

Invus recognizes that every company is unique and that extraordinary business performance cannot be achieved by following a formulaic approach. Due to their unique structure, they have a great deal of flexibility in the types of companies and situations where they can get involved. They know that real transformation takes time and that it is never a straight line. They fully align their incentives with their partners and have the wherewithal and long-term commitment to see through any bumps along the way. They have been successfully empowering owner-managers since 1985. They have been reinvesting the same pool of money from the same group of European families (through their Artal investment vehicle) since their founding. Today they manage over $4 billion in an evergreen fund and work out of offices in New York, London, Paris and Hong Kong.

Invus

Pavilion Capital Partners is a growth-oriented private equity investor. It provides capital and strategic support to companies in the United States and Asia. In particular, the focus is on industries experiencing high growth due to globalization, technology, or demographic trends.  It actively works with company founders/management to assist in strategic initiatives, mergers and acquisitions, and eventual liquidity. The pavilion is partnered with family offices and private equity funds and is based in New York City.

Pavilion Capital Partners

Sixty Degree Capital is a North American VC that invests in companies creating meaningful change in their industries, across sectors (software, digital infrastructure, healthcare, biotech) and across stages (as early as Series A, as late as pre-IPO). The firm has a global investment mandate, but currently focuses on the US market.

Sixty Degree Capital

Laurion Capital Management is an investment firm that provides a multi-disciplinary approach to capital markets investing. To collect qualitative and quantitative perspectives and data points, the company's research and investing teams use a wide aperture. Laurion Capital Management pursues investment opportunities across a variety of asset classes at the point where the qualitative and quantitative meet.

Laurion Capital Management

Schrödinger

Artificial intelligence is identifying and testing new therapies faster than ever.

AI Drug Discovery

<div>
 
 Nimbus Therapeutics is a biotechnology company designing small molecule compounds targeted at various diseases. It utilizes the chemical simulation computational platform built by co-founder Schr&ouml;dinger Inc., which incorporates artificial intelligence and machine learning, and co-develops drugs by partnering with pharma companies. Its pipeline includes programs in metabolic diseases, cancer, and immune-inflammatory disorders.&nbsp;
 
 
 As of March 2024, the company was developing five targets, of which one is in the clinical stage, two are in the preclinical stage, and others remain at a discovery stage. The company initiated investigational new drug (IND)-enabling studies on two novel agents in 2022.
 
 
 Takeda Pharmaceuticals acquired Nimbus Therapeutics&rsquo;s fully owned subsidiary, Nimbus Lakshmi, and its tyrosine kinase 2 (TYK2) (intracellular enzyme) program 
 <a href="https://sp-edge.com/updates/16314">
 in February 2023
 </a>
 . Following the acquisition, Nimbus&rsquo; drug candidate, NDI-034858, for psoriasis was renamed to &ldquo;TAK-279.&rdquo;&nbsp;
 
 
 Key customers and partnerships
 
 
 Nimbus Therapeutics&rsquo;&nbsp; pharma partners include Roche&rsquo;s Genentech, Celgene, and Gilead.
 
 In 
 <a href="https://sp-edge.com/updates/24983">
 December 2023
 </a>
 , Nimbus Therapeutics partnered with Anagenex to discover small-molecule drugs for various complex targets. Further, in October 2022, the company partnered with Eli Lilly to progress the development of novel targeted therapies that activate AMPK to potentially treat a broad range of metabolic disorders.
 
 
 Funding and financials
 
 
 In September 2023, the company raised USD 210 million in a 
 <a href="https://sp-edge.com/updates/21624">
 private funding round
 </a>
 co-led by GV (Google Ventures) in September 2023 to advance Nimbus Therapeutics' pipeline of drugs for various disorders. 
 
</div>

Targeting complex diseases with complex molecules

Large-molecule Therapeutics

Structure Therapeutics Inc. is a clinical-stage global biopharmaceutical company focused on developing novel oral small molecule therapeutics for metabolic and pulmonary diseases. The company's platform enables the conversion of biologics and peptide therapeutics into orally available small molecule drugs with enhanced pharmaceutical properties, including improved bioavailability and stability. This is achieved by leveraging structure-based drug discovery and computational chemistry expertise.
Structure Therapeutics targets G-protein-coupled receptors (GPCRs), a family of receptors that sense and respond to external signals. As of September 2022, the company completed Phase 1 single ascending dose (SAD) and multiple ascending dose (MAD) studies for its lead candidate GSBR-1290, a selective GLP-1 receptor agonist targeting type two diabetes mellitus and obesity. Positive results from the Phase 1 billion MAD study in overweight or obese individuals demonstrated significant weight loss supporting once-daily dosing.
In September 2022, Structure Therapeutics also completed a Phase 1 SAD and MAD study for ANPA-0073, targeting the apelin receptor for treating idiopathic pulmonary fibrosis and pulmonary arterial hypertension. The company is additionally advancing a differentiated lysophosphatidic acid one receptor antagonist for idiopathic pulmonary fibrosis.
Structure Therapeutics successfully went public on the Nasdaq in February 2023, raising USD 161 million in an upsized initial public offering. The company was co-founded by Raymond Stevens, Ph.D., a pioneer in structure-based drug discovery, and Schrödinger, a computational physics-based drug design company.

Ajax Therapeutics is an NYC-based biotechnology company applying computational chemistry and structure-based technologies to develop novel small molecules for hematologic malignancies

Structure Therapeutics creates life-changing medicines for patients using advanced computational and structure-based technology. Our platform combines the latest advancements in computational chemistry, visualization of molecular interactions, and data integration to design orally available, superior medicines that overcome current limitations in biologic and peptide drugs. We are advancing our clinical-stage pipeline of differentiated, efficacious and safe treatments focused on chronic diseases with high unmet need, including cardiovascular, metabolic and pulmonary conditions. At Structure, our team’s deep experience with complex biological targets and mechanisms, structure-based drug design, and global drug discovery and development enables our bold vision: to design and develop world-class medicines with tremendous patient impact and broad commercial opportunity.

Bright Angel Therapeutics is a developer of novel therapeutics designed to provide treatment of drug-resistant and life-threatening fungal infections. The company's services increases efficacy of current treatments and eradicates drug resistance by targeting the stress responses required by fungi for survival, virulence and drug resistance, enabling users to overcome the frequent emergence of clinical resistance largely responsible for the severe morbidity and mortality associated with infection by diverse fungal pathogens.

Morphic Therapeutic is a biotechnology company that develops oral integrin therapies to treat serious chronic diseases, including autoimmune, cardiovascular, and metabolic diseases, fibrosis, and cancer. The company offers the development of therapies for patients with immunological, fibrotic, neoplastic, and vascular diseases, focusing on creating small molecule inhibitors of various integrin targets.

Nimbus Discovery is now Nimbus Therapeutics to reflect our transition into a clinical-stage company. Nimbus Therapeutics is a biotechnology company headquartered in Cambridge, Mass., that is pioneering a new computational technology-driven paradigm to rapidly advance a diverse pipeline of novel small molecule product candidates into clinical development. Nimbus Therapeutics designs highly selective and potent medicines to disrupt known drivers of serious diseases, including metabolic disease, cancer, and immune-inflammatory disorders.

Schrödinger develops a computational platform that facilitates the research efforts of biopharmaceutical and industrial companies, academic institutions, and government laboratories worldwide. Schrödinger also has wholly-owned and collaborative drug discovery programs in a broad range of therapeutic areas. Schrödinger is deeply committed to investing in the science and talent that drive its computational platform.

<div>Schr&ouml;dinger operates a physics-based software platform to provide computational services for drug discovery. Its platform has been built on the foundation of physics, combined with the rapid data processing and scaling advantages of machine learning. Schr&ouml;dinger claims physics-based simulation is capable of predicting the binding affinity of a drug molecule with a high degree of accuracy, which can, in turn, lead to the accelerated discovery of new efficacious therapies.&nbsp;</div>

Schrödinger Reports Inducement Grants under Nasdaq Listing Rule 5635(c)(4) - December 17, 2024

Novartis

To identify and advance therapeutics for undisclosed targets in Novartis' core therapeutic areas.

Biotechnology companies that have integrated AI as a core component of their in-house drug development process. They typically have a few in-house drug development programs, and also collaborate with pharma companies to develop certain drugs.

Ajax Therapeutics

Goldman Sachs Asset Management

RA Capital Management

EcoR1 Capital

Vivo Capital

Boxer Capital

Point72 Ventures

Eli Lilly & Company Foundation

Inning One Ventures

Eli Lilly

Schrödinger collaborates with Eli Lilly for small molecule compound discovery and optimization.

Structure Therapeutics

Biotechnology Value Fund

Lilly Asia Ventures

Casdin Capital

TF Capital

Cormorant Asset Management

Eight Roads Ventures

F-Prime Capital

Sage Partners

Monashee Capital Corp.

HongShan

Janus Henderson Investors

Surveyor Capital

Terra Magnum Capital Partners

Woodline Partners

Stork Capital

TCG Crossover

Companies specializing in peptide-based treatments leverage short amino acid chains, known as peptides, to target and modulate various biological processes for therapeutic applications

Memorial Sloan - Kettering Cancer Center

NYU Langone Health

NVIDIA

Schrödinger partners with Nvidia expand the speed and accuracy of Schrödinger’s computational drug discovery platform

Bristol-Myers Squibb

Schrödinger, Inc. partners with Bristol Myers Squibb to develop and commercialize therapeutics across various diseases, leveraging advanced computational platforms and drug discovery capabilities.

Bayer

To develop a comprehensive de novo design solution with the objective to accelerate the discovery of innovative high-quality drugs.

SaaS (Software-as-a-Service) companies providing their ML platform to other pharma companies for drug discovery services such as target selection, validation and lead optimization.

Bright Angel Therapeutics

MaRS Investment Accelerator Fund

Toronto Innovation Acceleration Partners

Lumira Ventures

Viva BioInnovator

adMare Bio Innovations

AstraZeneca

To incorporate its machine learning and molecule-modelling platform within its drug discovery work. AstraZeneca’s researchers hope to use the programs to identify new therapeutics, while Schrödinger’s staff will work to integrate the platform within the drugmaker’s workflows and share best practices, according to the companies.

Focused on refining a biologics modeling solution with the aim of speeding up the development of antibody and protein-based therapeutic candidates.

<div>
 
 Schr&ouml;dinger operates a physics-based software platform to provide computational services for drug discovery. Its platform has been built on the foundation of physics, combined with the rapid data processing and scaling advantages of machine learning. Schr&ouml;dinger claims physics-based simulation is capable of predicting the binding affinity of a drug molecule with a high degree of accuracy, which can, in turn, lead to the accelerated discovery of new efficacious therapies.&nbsp;
 
 
 The company operates in two main segments: 1) a software segment that licenses its platform for molecular discovery in the life sciences and materials science industries, and 2) a drug discovery segment which focuses on creating a portfolio of preclinical and clinical programs, both internally and through collaborations.&nbsp;
 
 
 As of March 2024, the company had seven wholly-owned disclosed programs, with two in Phase 1 clinical stage, one in preclinical stage, and the rest in the discovery stage. In addition, the company had several undisclosed programs, which are in the discovery stage.&nbsp;
 
 
 Key customers and partnerships
 
 
 Schr&ouml;dinger has established drug discovery collaborations with various pharma companies, including Sanofi, Loxo Therapeutics, Bristol Myers Squibb, Lilly, Nimbus Therapeutics, Morphic Therapeutic, Structure Therapeutics, and Takeda Pharmaceutical.&nbsp;
 
 
 Further, through the software segment, the company has supported the development of two drugs in collaboration with Agios which were approved by the FDA in 2017.&nbsp;
 
 
 Funding and financials
 
 
 The company filed for an IPO in February 2020, raising USD 202 million. For 
 <a href="https://ir.schrodinger.com/press-releases/news-details/2024/Schrdinger-Reports-Strong-Fourth-Quarter-and-Full-Year-2023-Financial-Results/default.aspx">
 FY2023
 </a>
 , the company recorded revenue of USD 216.7 million, a 19.7% YoY increase. Further, the company recorded a net income of USD 40.7 million in FY2023, compared to a net loss of USD 149.2 million in FY2022.
 
</div>

<div>
 
 HiberCell is a biotechnology company that develops novel therapies focused on oncology. It entered the AI drug discovery space when it acquired AI genomics analysis company Genuity Science (and its subsidiaries in Iceland and Ireland) in August 2021.&nbsp;
 
 
 Genuity Science&rsquo;s solutions include end-to-end therapeutic discovery and development services such as building custom disease datasets, discovering and prioritizing targets, identifying biomarkers, and optimizing clinical trials. Genuity Science leverages its AI-powered platform to manage, process, and analyze genomic data. HiberCell intends to use Genuity Science&rsquo;s AI/ML capabilities to advance its oncology pipeline of five programs, of which one has reached the Phase 2 clinical trial stage.
 
 
 As of March 2024, the company&rsquo;s pipeline included three drug candidates, namely: 1) HC-7366, targeting the general control nonderepressible 2 (GCN2) kinase as part of the integrated stress response (ISR) signaling pathway; 2) HC-5404, aimed at inhibiting the PKR-like endoplasmic reticulum kinase (PERK) involved in the unfolded protein response (UPR) signaling pathway; and 3) odetiglucan, a therapy targeting tumor-immune interactions within the tumor microenvironment​.&nbsp;
 
 
 Key customers and partnerships
 
 
 In December 2023, HiberCell and Merck &amp; Co partnered to conduct a Phase Ib trial to evaluate the combination therapy of belzutifan and HC-7366 for treating clear cell renal cell carcinoma. Further, in January 2021, the company partnered with Biodesix to develop an enzyme-linked immunosorbent assay as a companion diagnostic test.
 
 
 Funding and financials
 
 
 In 
 <a href="https://hibercell.com/news/hibercell-closes-67-4-million-series-b-financing-and-secures-30-million-debt-facility-from-hercules-capital/">
 May 2021
 </a>
 , HiberCell completed a Series B financing round, raising USD 67.4 million, and secured an additional USD 30 million in debt financing from Hercules Capital. The funds were expected to be used for clinical advancement of its novel therapeutic candidates. 
 
</div>

HiberCell

<div>
 
 Arbor Biotechnologies specializes in gene editing to develop novel therapeutics for a variety of indications, starting with liver-related diseases. It operates an AI-powered biodiscovery platform to discover novel CRISPR enzymes, which are sequences of repeating genetic code. To do this, its platform deploys computational search techniques, genome sequencing, gene synthesis, and high-throughput screening. This can eventually be turned into drugs or even applied to agriculture and other industrial uses. In 2018, the company announced the discovery of Cas13d, a new type of gene editing enzyme that helps to alter RNA to treat genetic diseases.&nbsp;
 
 
 As of February 2024, the company had five internal drug discovery programs, of which one was in the IND-enabling stage. It also has multiple collaborative programs under development focused on oncology and various other therapeutic areas.
 
 
 Key customers and partnerships
 
 
 The company has a long-standing partnership with Vertex Pharmaceuticals since
 <a href="https://www.businesswire.com/news/home/20190103005194/en/Vertex-and-Arbor-Biotechnologies-Establish-Collaboration-to-Discover-Novel-Proteins-to-Advance-Discovery-of-Gene-Editing-Therapies">
 January 2019
 </a>
 , which focused on developing gene-editing treatments for cystic fibrosis and four other diseases. The alliance was further extended in 
 <a href="https://www.biospace.com/article/vertex-and-arbor-strike-a-1-2-billion-deal-for-gene-editing-programs/">
 August 2021
 </a>
 and 
 <a href="https://sp-edge.com/updates/15741">
 January 2023
 </a>
 .&nbsp;
 
 
 Other partnerships included a collaboration with 
 <a href="https://www.prnewswire.com/news-releases/arbor-biotechnologies-announces-collaboration-with-ginkgo-bioworks-to-advance-the-discovery-and-development-of-precision-gene-editors-302011991.html">
 Ginkgo Bioworks
 </a>
 (December 2023) to leverage Ginkgo's R&amp;D services to further optimize Arbor's novel precision editors, a non-exclusive licensing agreement with 
 <a href="https://www.globenewswire.com/news-release/2022/02/08/2380680/0/en/EdiGene-and-Arbor-Biotechnologies-Announce-Worldwide-Non-exclusive-License-Agreement-to-Advance-Ex-Vivo-Engineered-Cell-Therapy-Programs.html">
 EdiGene
 </a>
 (February 2022) to leverage Arbor&rsquo;s platform for ex vivo oncology therapies, a strategic research and non-exclusive licensing agreement with 
 <a href="https://investors.tcr2.com/news-releases/news-release-details/tcr2-therapeutics-and-arbor-biotechnologies-establish">
 TCR2 Therapeutics
 </a>
 (January 2022) to develop allogeneic TRuC T-cell therapies using Arbor&rsquo;s CRISPR technology, and a license agreement with 
 <a href="https://www.lonza.com/news/2020-12-23-14-00">
 Lonza
 </a>
 (December 2020) to use Arbor&rsquo;s gene-editing technology for Lonza&rsquo;s bioproduction products and services.
 
 
 Funding and financials
 
 
 In its latest Series B funding round in November 2021, which was led by Ally Bridge Group, TCG Crossover, and Temasek, Arbor Biotechnologies raised USD 215 million. The proceeds of the round were earmarked to fuel the company&rsquo;s clinical development pipeline.
 
</div>

Arbor Biotechnologies

Based in the UK, Arctoris provides an automated drug discovery platform, offering fully validated research and development (R&amp;D) processes under an Experiments-as-a-Service model. The company works with biotechnology companies, AI drug discovery companies, pharma and academic institutions enabling these institutions to run experiments in Arctoris’s platform and provides on-demand access to a broad scale of datasets for AI drug discovery companies to train their algorithms.

Arctoris

<div>
 
 Frontier Medicines leverages AI/ML technologies to develop treatments for cancer-causing proteins that are dismissed by traditional pharma companies as undruggable.&nbsp;
 
 
 The company has a proprietary chemoproteomic platform which entails an approach based on the interaction of small-molecule compounds and proteins to screen a large number of targets and combine them with a protein database that contains more than 150,000 novel binding pockets (hotspots). This enables it to access 90% of the human proteome that were not previously targeted due to lack of hotspots. The platform&rsquo;s AI/ML engine incorporates a library of diverse compounds, a hotspot map that serves as the starting point for understanding the druggability of a potential therapeutic target, and lead design and generation.&nbsp;
 
 
 The company focuses on oncology and immunology target and, as of February 2024, it had five wholly-owned therapeutic programs and three AbbVie-partnered programs in its pipeline. All programs were in their discovery stage, except the company&rsquo;s lead candidate, FMC-376 (activated and inactivated forms), focused on treating different cancer types, including non-small cell lung cancer (NSCLC), colorectal carcinoma (CRC), and pancreatic ductal adenocarcinoma (PDAC), which is in the IND-enabling stage.
 
 
 Key customers and partnerships
 
 
 The company entered a USD 100 million partnership with 
 <a href="https://news.abbvie.com/2020-12-02-AbbVie-and-Frontier-Medicines-Establish-Global-Partnership-to-Discover-and-Develop-Novel-Therapies-and-E3-Degraders-Against-Difficult-to-Drug-Targets">
 AbbVie
 </a>
 In December 2020 to develop small-molecule therapeutics against hard-to-drug protein targets including around 600 E3 ligases (the enzymes that drive the ubiquitination and degradation of proteins.&nbsp;
 
 
 Funding and financials
 
 
 In July 2021, the company raised USD 88.5 million in a 
 <a href="https://sp-edge.com/updates/4347">
 Series B
 </a>
 funding round co-led by Woodline Partners LP and RA Capital Management, with equal participation from Deerfield Management Company. The proceeds were earmarked for advancing the company&rsquo;s drug pipeline and expanding operations in Boston, where its new facility was to complement the company&rsquo;s headquarters in California. 
 
</div>

Frontier Medicines

<div>
 
 Verge Genomics is a biotechnology company engaged in developing therapeutics for neurological diseases using human genomics and AI to accelerate drug discovery. The main target areas are Amyotrophic Lateral Sclerosis (ALS), Parkinson&rsquo;s Disease (PD), and Frontotemporal Dementia (FTD).&nbsp;
 
 
 It has built a proprietary all-human platform (unlike standard clinical trials that rely on animal data), called CONVERGE, that uses data sets from brain tissue samples of deceased patients with ALS and PD. While most drugs target only one gene at a time, the company claims its technology can identify hundreds of genes that cause disease and develop drugs that target all the genes at the same time. The company uses AI technology to optimize the drug discovery process as a whole.
 
 
 As of March 2024, Verge had one drug candidate in the clinical stage (Phase I) and 10 drug candidates in the discovery stage.&nbsp;
 
 
 Key customers and partnerships
 
 
 The company has partnerships with various tissue banks (such as Harvard University and University of Miami Miller School of Medicine) and several educational institutes and foundations (such as Target ALS, Answer ALS) that enabled its drug discovery platform.&nbsp;
 
 
 In addition, the company&rsquo;s customers include several pharmaceutical companies, such as 1) 
 <a href="https://www.vergegenomics.com/news-blog/verge-genomics-announces-research-collaboration-with-the-sheffield-institute-for-translational-neuroscience">
 Sheffield Institute for Translational Neuroscience (SITraN)
 </a>
 to accelerate the validation of novel drug targets and screening of drug compounds for Parkinson's disease (February 2021), 2) 
 <a href="https://sp-edge.com/updates/4146">
 Eli Lilly
 </a>
 to research and develop novel therapies to treat ALS (July 2021), 3) 
 <a href="https://sp-edge.com/updates/21707">
 Alexion
 </a>
 to identify novel drug targets for rare neurodegenerative and neuromuscular diseases (September 2023), and 4) 
 <a href="https://www.vergegenomics.com/news-blog/verge-genomics-and-the-pritzker-neuropsychiatric-disorders-research-consortium-form-cutting-edge-schizophrenia-research-collaboration">
 Pritzker Neuropsychiatric Disorders Research Consortium
 </a>
 to analyze data from schizophrenic patient&rsquo;s brain tissue with Verge&rsquo;s technology (October 2023).
 
 
 Funding and financials
 
 
 In December 2021, Verge raised USD 98 million in an oversubscribed 
 <a href="https://sp-edge.com/updates/7426">
 Series A
 </a>
 funding round led by BlackRock. The funds were used to scale up its pre-clinical and clinical candidate programs in the pipeline and enhance its lead therapeutics through clinical testing. 
 
</div>

Verge Genomics

SaaS (Software-as-a-Service) companies providing their ML platform to other pharma companies to design and run preclinical experiments.

SaaS (Software-as-a-Service) companies providing their ML platform to other pharma companies to identify biomarkers (measurable biological signs used to determine disease progression) and predict drug response.

SaaS (Software-as-a-Service) companies aggregating and analyzing biomedical data with the help of AI to generate insights across the drug development pipeline.

Includes companies that use GenAI as a core part of their product offering for drug discovery & development

Companies leverage GenAI to support drug discovery through accelerated drug designing

Companies offer AI/ML-based SaaS products to accelerate the discovery and development of novel therapeutics

Offers AI/ML-based solutions to accelerate drug discovery and development

INCUMBENTS_PRESENT

PROMINENT_CATEGORY

<div>
 Schrödinger, a provider of a computational drug discovery platform, has entered into a partnership with Novartis for therapeutic development and for the expansion of software licensing for drug discovery programs.
 The partnership, set to last multiple years, involves joint research endeavors aimed at identifying and advancing therapeutics for undisclosed targets within Novartis' core therapeutic areas. Novartis will gain increased access to Schrödinger's technology which includes computational predictive modeling and an enterprise informatics platform.
 As part of the agreement, Schrödinger will receive USD 150 million upfront from Novartis. Potential earnings could reach up to USD 892 million in milestone payments, and USD 1.38 billion in commercial milestones. Additionally, royalties on product sales will also be paid to Schrödinger. Novartis will be responsible for clinical development, manufacturing, and global commercialization.
</div>

Schrödinger

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