UNIIQ is een investeringsfonds van € 22 mln. gericht op de proof-of-concept fase. UNIIQ helpt ondernemers in Zuid-Holland om hun unieke innovatie sneller naar de markt te brengen. Wij bieden ondernemers het startkapitaal om hun plannen te realiseren en de meest risicovolle fase van concept tot veelbelovend bedrijf te overbruggen.  Door intensieve samenwerking met kennisinstellingen en incubators kunnen we ondernemers actief ondersteunen in hun strategische ontwikkeling. De UNIIQ investering wordt gebruikt om de innovatie en het businessconcept te valideren. Het proces is erop gericht om de stap naar vervolgfinanciering te maken. Wij hanteren een helder proces met ondernemersvriendelijke voorwaarden.

UNIIQ

Delft Enterprises participates in innovative, early stage and technology-based spin off companies of Delft University of Technology.

Delft Enterprises

Graduate Entrepreneur is here to stimulate the start-up ecosystem in Delft and Rotterdam. We invest in founders of inspiring ventures from Pre-Seed to Seed & Series A, backed by an extensive network of successful entrepreneurs. We also provide you with a vast selection of supporters that help you along at every step.

Graduate Entrepreneur Fund

First  is a pre-seed fund that finances pioneering scientists in The Netherlands active in the emerging fields of regenerative medicine and cardiovascular diseases. We support the leading scientists in these fields to turn their breakthrough discoveries into sustainable, innovative companies that can develop the products needed to improve patient’s lives. We harness their excellent science, foster the development into a product vision, and leverage our extensive network to attract follow-on investments.

First

LEH focuses on investing in science-based startups.

The TTT program assists researchers in bringing their research ideas to the next level, validating them, and establishing a profitable spin-off. TTT promotes, assist, and expedite the development of prospective spin-off firms by combining the skills of the four Dutch technical universities with those of TNO

Thematic Technology Transfer

XS Innovations

XS Innovations is developing vascular access devices to avoid continuous high flow, dramatically reducing complications in patients.

XS Innovations is a medical technology company focused on developing innovative solutions for patients with end-stage kidney disease (ESKD). The company's primary product is the Dynamic AVF, a vascular access device designed to address complications associated with hemodialysis. Unlike traditional arteriovenous fistulas (AVF) that maintain continuous high blood flow, the Dynamic AVF connects the artery and vein only during dialysis, keeping the AVF closed at other times to ensure normal blood circulation. This approach aims to reduce complication rates and extend the lifespan of vascular access for ESKD patients. XS Innovations estimates that approximately 4 million patients globally are affected by ESKD, with 70% relying on hemodialysis for treatment. The company projects this number to increase to 5.4 million by 2030, driven by factors such as increasing access to treatment, exposure to lifestyle risk factors, and a growing elderly population worldwide. XS Innovations emerged as a spinout from Leiden University Medical Center (LUMC) and Delft University of Technology (TU Delft), leveraging research conducted at these institutions to develop its technology.

€1.1 million raised by XS Innovations for vascular access device

XS Innovations raises investment for vascular access device

Pushing the envelope in MedTech with emerging technologies

Next-gen Medical Devices

XS Innovations is a medical technology company focused on developing innovative solutions for patients with end-stage kidney disease (ESKD). The company's primary product is the Dynamic AVF, a vascular access device designed to address complications associated with hemodialysis. Unlike traditional arteriovenous fistulas (AVF) that maintain continuous high blood flow, the Dynamic AVF connects the artery and vein only during dialysis, keeping the AVF closed at other times to ensure normal blood circulation. This approach aims to reduce complication rates and extend the lifespan of vascular access for ESKD patients. XS Innovations estimates that approximately 4 million patients globally are affected by ESKD, with 70% relying on hemodialysis for treatment. The company projects this number to increase to 5.4 million by 2030, driven by factors such as increasing access to treatment, exposure to lifestyle risk factors, and a growing elderly population worldwide. XS Innovations emerged as a spinout from Leiden University Medical Center (LUMC) and Delft University of Technology (TU Delft), leveraging research conducted at these institutions to develop its technology.

Convergent Dental, Inc. is a privately owned dental equipment and technology company. Its flagship product, Solea, is the only CO2 laser cleared by the FDA for all-tissue indications, delivering an anesthesia-free, blood-free, and suture-free experience for dentists and patients. Solea represents a breakthrough in dental laser technology, offering a distinct experience compared to traditional instruments or earlier laser treatments.
Solea is a novel 9.3-micron CO2 laser that nears the peak absorption of hydroxyapatite (enamel), enabling it to vaporize enamel with speed and precision. This unique wavelength, coupled with computer-controlled motors (galvos) that manipulate the beam thousands of times per second, allows dentists to perform procedures ranging from hard tissue to soft tissue with total control and efficiency.
A key feature of Solea is its variable-speed foot pedal, which lets dentists seamlessly transition from hard to soft tissue by adjusting the pressure applied. This intuitive design streamlines the learning curve for dentists accustomed to using a drill. Solea's three ergonomic handpieces – Contra-Angle, Straight, and Ultraguide – further enhance its versatility across various procedures.
Solea not only improves patient experiences but also offers practice benefits such as increased productivity, new patient flow, and efficiency gains. In October 2022, Convergent Dental received FDA clearance for Solea to aid in reducing mineral loss in dental enamel, protecting teeth against acid attack and caries development. This breakthrough application was commercially launched in November 2023 under the name Solea Protect.

Convergent Dental

Ossio is an orthopedic fixation technology company that has developed OSSIOfiber Intelligent Bone Regeneration Technology, a breakthrough implant material designed to securely fixate and fully integrate into the body's native anatomy without leaving any permanent hardware behind. This technology addresses the limitations of conventional metal and resorbable implants, combining unparalleled mechanical strength with natural bone healing.
Made from a proprietary mineral fiber matrix held together by a naturally degradable polymer, OSSIOfiber implants provide surgeons with a more biologically friendly way to restore patient stability and mobility. These implants are engineered to provide the strength required for functional fixation while allowing full integration into the native bone without adverse biological response.
Ossio's product portfolio includes compression screws, trimmable fixation nails, hammertoe fixation systems, suture anchors, and compression staples, all made with OSSIOfiber technology. These implants have received multiple FDA clearances since 2019, and the company has initiated commercialization of its products in the US. As of March 2022, over 6,000 implantations of OSSIOfiber products had been performed, demonstrating adoption of this innovative technology.
OSSIOfiber Intelligent Bone Regeneration Technology can address various surgical applications through the manufacturing of implant designs like nails, screws, staples, anchors, and plates. Ossio plans to pursue multiple applications in distal extremities, trauma, sports, reconstruction, pediatrics, and spine segments.
In February 2023, Ossio launched the world's first and only non-permanent compression staple made with OSSIOfiber technology, designed for predictable bone in-growth, regeneration, and replacement.

Ossio

Casana is a healthcare technology company that has developed the Heart Seat, an innovative toilet seat that enables effortless, integrated, and consistent in-home health monitoring. The Heart Seat is a replacement for a standard toilet seat and is designed to measure key clinical parameters such as heart rate, blood oxygen saturation (SpO2), and blood pressure.
In May 2023, Casana received FDA clearance for the Heart Seat to measure heart rate and SpO2 in adults aged 22 years and older, weighing between 90 to 350 pounds. The company plans to file for additional indications, including systolic and diastolic blood pressure, with the goal of launching the product in the market by the end of 2023.
The Heart Seat is equipped with sensors that passively capture health data whenever the seat is used, eliminating the need for user compliance or behavior changes. The data is automatically uploaded to the Casana Cloud, where it can be viewed by healthcare providers, enabling them to monitor patients' health trends and respond to changes in near real-time.
Casana's technology allows for the effortless collection of consistent and reliable data, assisting medical teams in monitoring chronic conditions beyond the hospital or physician's office. The company aims to unlock a new category in healthcare technologies that enables seamless, integrated, and continuous in-home health monitoring.
In January 2022, Casana was acquired by an undisclosed entity, further accelerating the commercialization of the Heart Seat.

Casana

Neurent Medical is a company pioneering innovative non-surgical interventions to treat chronic inflammatory sinonasal diseases, particularly chronic rhinitis. The company's flagship product is the NEUROMARK System, a device that received US Food and Drug Administration (FDA) 510(k) clearance in October 2021.
The NEUROMARK System is designed to gently apply controlled low-power radio frequency (RF) energy to target regions of the nasal cavity, disrupting the parasympathetic nerve signals that can trigger an inflammatory response. This alleviates chronic rhinitis symptoms such as persistent congestion, rhinorrhea (runny nose), swelling of the mucosal membrane, sneezing, and nasal itching. The system's unique flexible leaflet design and proprietary smart algorithms enable precise neurolysis (disruption) of the posterior nasal nerves (PNN) and accessory pathways, accommodating a range of patient anatomies while maintaining mucosal and vascular integrity.
Neurent Medical announced the limited market release of the NEUROMARK System in the US in February 2023, following the establishment of a new Category I Current Procedural Terminology (CPT) code by the American Medical Association (AMA) for PNN procedures, effective January 2024. The American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) also endorsed the PNN procedure in 2023.

Neurent Medical

Genetesis is a medical imaging company specializing in biomagnetic cardiac imaging solutions. It has developed CardioFlux, a flagship magnetocardiography (MCG) system that non-invasively identifies myocardial ischemia, a condition where blood flow to the heart muscle is reduced. The technology measures the magnetic fields generated by the heart's electrical activity to detect ischemia within minutes, without using pharmaceuticals or radiation. CardioFlux MCG is designed to provide advanced imaging while prioritizing patient comfort.
The company's solutions target the diagnosis of coronary microvascular disease (CMD), a condition that has been challenging to identify due to a lack of effective functional diagnostics. By offering an accurate and rapid test for CMD, Genetesis aims to address an unmet clinical need and enable timely management of the condition.
In April 2023, the US Food and Drug Administration (FDA) granted CardioFlux MCG Breakthrough Device designation for the non-invasive diagnosis of myocardial ischemia in patients suspected of having CMD.
Genetesis was founded in 2013 and is headquartered in Mason, Ohio. The company has received over USD 40 million in funding to date, including a USD 17.5 million Series C round in October 2022. In April 2020, TDK Ventures, the corporate venture capital arm of TDK Corporation, invested in Genetesis, providing access to TDK's expertise in areas like biomagnetic sensors and magnetic noise suppression.

Genetesis

Companies that develop diagnostic devices used in a hospital setting to identify a disease, condition, or injury, such as imaging systems and endoscopes

Companies that develop implantable medical devices designed to be surgically placed inside the human body, either temporarily or permanently, including devices such as pacemakers, artificial joints, stents, and cochlear implants

Companies that develop non-surgical devices that are used in a procedure or intervention to cure or relieve a patient from an illness or disease such as laser treatments, dental equipment, and wound care management

Companies that develop monitoring devices that are used in a hospital setting to measure patient vital signs and ensure patient well-being post-treatment, such as cardiac and respiratory monitoring systems

Providers of software that enhances the functionality of medical device hardware (diagnosis, treatment, and monitoring)

Companies that develop surgical devices involving invasive interventions (cutting into a patient's body tissues) to treat, cure, or relieve a patient of an illness or disease

Companies that develop devices to administer pharmaceutical substances into a patient's body, ensuring controlled release or targeted delivery, specifically for use in clinical settings to treat or manage medical conditions effectively

Providers of software that helps manage risks, ensure quality, and streamline audit processes during medical device development

IoT connects devices to EHR systems for precise patient diagnosis and treatment support

Devices are linked to software platforms that use digital technologies such as AI/ML and VR

Startups leverage AI/ML and deep learning to support patient diagnosis and early detection

XS Innovations

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