Lyndra Therapeutics

Lyndra Therapeutics is a clinical-stage biopharmaceutical company pioneering long-acting oral therapies. The company's proprietary LYNX drug delivery platform enables the creation of medicines that can last for a week or longer in an oral dosage form. This platform represents a significant advance in oral drug delivery, aiming to dramatically reduce dosing frequency compared to traditional daily pills. Lyndra's lead product candidate is oral weekly risperidone (LYN-005), which is being developed for the treatment of schizophrenia and bipolar I disorder. In January 2024, Lyndra reported positive results from the Phase III STARLYNG-1 clinical trial of LYN-005, meeting its primary endpoint. The company is also developing other long-acting oral therapies, including oral weekly dapagliflozin (LYN-045) for diabetes and oral weekly aripiprazole (LYN-006) for mental health conditions. Additionally, Lyndra is working on oral biweekly ivermectin (LYN-163) as a potential tool in the fight against malaria. The LYNX platform originated from technology invented at the Massachusetts Institute of Technology (MIT) and has progressed rapidly since 2015 through preclinical and human studies. Lyndra has a state-of-the-art GMP manufacturing facility in Lexington, Massachusetts.

Key customers and partnerships

Lyndra Therapeutics has established partnerships with several notable organizations to advance its long-acting oral therapies. The company has received product funding from the Bill & Melinda Gates Foundation, particularly for the development of oral biweekly ivermectin. In December 2023, as part of a USD 101 million Series E financing round, Lyndra entered into an agreement with Sun Pharmaceutical Industries Limited. This partnership grants Sun Pharma an exclusive license to manufacture and market Lyndra's oral weekly risperidone, dapagliflozin, and aripiprazole in six countries, including India and Brazil, pending further clinical development. Lyndra has previously received funding from AbbVie and Gilead Sciences, Inc., indicating potential interest from major pharmaceutical companies in its technology platform. The company's focus on developing therapies for conditions like schizophrenia, bipolar disorder, and opioid use disorder suggests potential future partnerships or customers in the mental health and addiction treatment sectors.