HealthInvest Equity Partners (“HealthInvest”) is an investment firm focused on starting and growing successful healthcare businesses. Over the past 15 years, the principals of the firm have invested in many successful healthcare services start-up companies, including American Renal Associates (sold to Wachovia Capital Partners), Ascend Health Corporation (sold to Universal Health Services - NYSE: UHS), Medicus (sold to NORCAL Mutual Insurance Co.), Odyssey Healthcare, Inc. (NASDAQ: ODSY, later sold to Gentiva – NASDAQ: GTIV), Sempercare, Inc. (sold to Select Medical – NYSE: SEM), US Healthworks (sold to Dignity Health), Free and Clear (sold to Inverness (now Alere)). Current active healthcare services investments managed by the principals include CareWell Urgent Care Centers of New England, Inc., Dicom Grid, Inc., Ella Health, Inc., Fidelis SeniorCare, Inc., and Medmark Services, Inc. In all of these companies, the HealthInvest Equity Partners principals were founding or among the first institutional investors.

HealthInvest Equity Partners

Canaan is an early stage venture capital firm that invests in entrepreneurs with visionary ideas. With $5B under management, a diversified fund and over 190 exits to date, Canaan has invested in some of the world's leading technology and healthcare companies over the past 30 years. Canaan’s focus areas include fintech, enterprise/cloud, marketplaces, frontier tech, biopharma, digital health, and medtech.

Canaan Partners

Flywheel Ventures is a seed and early-stage venture capital firm focused on information technology and physical sciences ventures in the Southwest/Rockies region. Flywheel's goal is to be the premier early-stage technology venture capital firm in the Southwest/Rockies region and a catalyst for its emergence as a world-class technology center.

Flywheel Ventures

Techammer is an angel investor who helps founders solve important problems. Designers invest in data science, digital health, and companies that accelerate science. Companies that improve the lives of ordinary Americans pique our interest. The designers are both Midwesterners (Jeff from Michigan/Indiana and Halle from Ohio), and we both started our careers bagging groceries. Designers met in San Francisco, where we both lived for three months. The designers got married in Italy and just moved to the East Coast.

Techammer

Illumina Ventures is an independently managed venture fund in a strategic partnership with Illumina. Illumina provides the majority of their capital and access to the expertise and vision of the world's leading genomics solutions provider. They invest primarily in early stage companies, in areas where their expertise and special relationship with Illumina can add value. They typically syndicate with other leading institutional and strategic investors. Focus areas include applications of genomics in life science research, healthcare, agriculture and environmental science, public safety and personal wellness.

Illumina Ventures

Blue Ivy Ventures is a community of Yale alumni: investors, executives, entrepreneurs, and innovation enthusiasts with a connection to Yale University.   Blue Ivy Ventures was founded in 2016 and is led by Managing Partner David Shapiro (Yale '91). Its Investment Committee and investors include experienced investors and entrepreneurs from around the country and across multiple generations.

Blue Ivy Ventures

Kaiser Permanente Ventures, the corporate venture capital arm of Kaiser Permanente, is dedicated to forming effective partnerships with innovative companies. Kaiser Permanente Ventures invests predominantly in HCIT and services, as well as diagnostics, drug delivery and therapeutic medical devices.

Kaiser Permanente Ventures

GE Ventures combines capital, technical, and commercial services. They invest in the healthcare and life sciences, energy and mobility, manufacturing and supply chain, enterprise productivity applications, digital infrastructure, and frontier technologies sectors.

GE Ventures

LRVHealth is the “Inside Healthcare” venture capital platform. LRVHealth’s investors include leading provider, payer, and vendor organizations, comprising a network that touches one in three healthcare consumers across the U.S. Together, this network collaborates to identify, invest in, and adopt innovative solutions to the industry’s most pressing needs. Founded in 2000 by an experienced team of healthcare investors, operators, and advisors, the LRVHealth team provides early stage capital, operating experience, and industry insights to build the next generation of great healthcare companies.

LRVHealth

Perceptive Advisors, LLC is a privately owned hedge fund sponsor. The firm invests in the public equity markets across the globe. It employs a long/short equity strategy as a hedging technique while making its investments. The firm typically invests in biotechnology and life sciences sectors to make its investments. Perceptive Advisors is based in New York, New York.

Perceptive Advisors

Casdin Capital is a fundamental research investment firm focused on the life sciences and healthcare industry. It manages a long-short equity fund and makes investments in early-stage to late-stage private investments.  Casdin was launched in 2012 by founder and CIO Eli Casdin and as of October 2020 has approximately $2.2 billion in assets under management.

Casdin Capital

The Manatt Venture Fund is the investment arm of [Manatt, Phelps & Phillips, LLP](/company/manatt-phelps-phillips-llp), a Los Angeles-based law firm. The Fund makes early-stage investments, and since its founding in 2000 it has made investments in over 90 companies. The official investment entity is MPP Holdings, LLC.

Manatt Venture Fund

Echo Health Ventures is a venture capital firm that focuses on investing in health care companies. From offices in Durham, Portland, and Seattle, Echo Health Ventures invests in health care companies. They work with portfolio companies to accelerate their innovations to scale nationally. As stage-agnostic investors, they are committed to a new approach to strategic investing – an approach that brings more than capital to the table, an approach focused on developing deep, high-value relationships with their portfolio companies.

Echo Health Ventures

Dreamers VC they invest in early stage companies through the application of emerging technology in seed, A, or B rounds.

Dreamers VC

Revelation Partners invests broadly across healthcare sectors with a focus on commercial companies with proven business models or companies with novel technologies that have clear clinical and regulatory pathways. They actively invest in the following healthcare verticals - medical devices, biopharmaceuticals, healthcare IT and healthcare services.

Revelation Partners

Manatt Ventures is a Los Angeles-based law firm.

Manatt Ventures

Alumni Ventures Group provides high-quality, diversified venture portfolios to individual investors who previously haven't had access to VC. It helps accredited alums from top entrepreneurial schools invest together in the ventures of fellow alums. The firm backs companies with an alumni connection and an institutional lead investor with expertise in the space. AVG also offers focused funds that allow any accredited investor access to a venture portfolio, diversified by type, sector, stage, and geography. Beth Obermiller, Michael Madden, and Mike Collins co-founded the firm in Manchester, New Hampshire in 2013.

Alumni Ventures

The Samsung Catalyst Fund is Samsung Electronics’ evergreen multi-stage venture capital fund that invests in the new data economy and strategic ideas for Samsung’s mobile, device solutions and consumer electronics groups. Investment spans across Automotive, Robotics, Digital Health, Internet of Things, Artificial Intelligence, Cloud Infrastructure, and Device-Level Solutions. Through Samsung Catalyst Fund, entrepreneurs are enabled by Samsung’s global brand, manufacturing and distribution, domain expertise, recruiting network, and world-class Innovation Fellows for advice and mentorship.

Samsung Catalyst Fund

Avestria Ventures is an investment firm that focuses on women's health and female-led life science and healthcare companies. They define women's health as illnesses that affect women exclusively (such as menopause), differently (such as cardiovascular disease), or disproportionately (such as Alzheimer's).

Avestria Ventures

GV supports innovative founders moving the world forward. We invest across the life sciences, consumer, enterprise, crypto, climate, and frontier technology sectors. With Alphabet as a sole limited partner, GV operates on long time horizons and deals in decades, not rounds. Our operating partners support startups at the earliest stages of company-building across design, equity, diversity & inclusion, talent, and engineering. We also help startups interface with Google, providing unique access to the world's best technology and talent. Launched as Google Ventures in 2009, GV has over $8 billion in assets under management and 400 active portfolio companies across North America and Europe. Notable investment outcomes include Uber, Nest, Slack, GitLab, Duo Security, Flatiron Health, Verve Therapeutics, and One Medical. GV is headquartered in the San Francisco Bay Area, with offices in Cambridge, New York, and London.

Google Ventures

Amgen Ventures is a venture capital investment arm of Amgen Inc. specializing in investments in early and later stage companies. The firm primarily invests in the biotechnology sector with a focus on discovering and developing human therapeutics with a focus on oncology, inflammation, hematology, nephrology, metabolic disorders, neuroscience, and cardiovascular therapeutics. In oncology and hematology it focuses on novel therapeutics including signal transduction, cell cycle, and apoptosis; hematopoiesis including anemia, neutropenia, and stem cell mobilization; and supportive care including mucositis and cachexia. In nephrology the firm focuses on renal failure and hyperparathyroidism. For inflammation the firm focuses on rheumatoid arthritis, psoriasis, systemic lupus erythematosus, inflammatory bowel disease, multiple sclerosis, asthma and COPD, and osteoarthritis. Under cardiovascular, it focuses on acute coronary syndromes, dyslipidemia, and heart failure and under metabolic disorders it focuses on diabetes, metabolic syndrome, and osteoporosis. The focus on neuroscience included pain including neuropathic and inflammatory, alzheimer's disease, parkinson's disease, sleep disorder, cognition, and schizophrenia. In discovery research and technology the firm focuses on early-stage drug discovery collaborations, innovative chemical entity collections, diagnostics and biomarkers, novel antibody platforms, assay biologicals and devices, and target-focused structural biology and computational tools. It primarily invests in the North America, Europe, and the United Kingdom. The firm typically invests between $2 million and $3 million per transaction and may invest up to $10 million per company. It prefers to have an ownership stake of less than 15 % in its portfolio companies. Amgen Ventures was founded in 2004 and is based in San Francisco, California with additional offices in Seattle, Washington; Thousand Oaks, California; and Cambridge, Massachusetts.

Amgen Ventures

Founded in 2019, Parkway operates at the intersection of vision and execution with a focus on cutting-edge technologies and business models. The firm is largely focused on the trend of digital transformation of businesses, products and systems with software and hardware technologies in data science, artificial intelligence (AI), simulation, automation, spatial computing, internet of things (IOT), augmented reality (AR), generative design and optimization technologies.  Parkway primarily targets investments in the Climate Tech, Construction Tech (Contech), Property Tech (Proptech), Generative Design, Business Intelligence, Health Tech, Metaverse and Direct-to-Consumer sectors. Companies in which Parkway investments typically have a software as a service, unique technology, valuable patents and intellectual property that make them highly competitive in the market, valuable to potential strategic acquirers and/or display the potential for high growth annual recurring revenue.

Parkway Venture Capital

Genome Medical

Genome Medical is a national telegenomics technology, services, and strategy company bringing genomic medicine to everyday care. Through its nationwide network of genetic specialists and an efficient Genome Care DeliveryTM technology platform, we provide expert virtual genetic care for individuals and their families to improve health and well-being. They also help health care providers and their patients navigate the rapidly expanding field of genetics and utilize test results to understand the risk for disease, accelerate disease diagnosis, make informed treatment decisions and lower the cost of care. The company was founded in 2016 and is based in South San Francisco, California, United States.

<div>Genome Medical offers cloud-based, virtual genomic services including genetic testing and counseling via its platform. The company serves both the D2C and B2B segments with a focus on therapeutic areas such as cancer, cardiovascular disease, reproductive health, pediatric genetics, pharmacogenomics, and proactive health management. Individuals attend an initial consultation with a genetic counselor to review their health history and their family's health history. Thereafter, the company will send a sample collection kit to the individual and the results will be shared with the genetic counselor, costing USD 179 per session.</div>

Leveraging personal data for custom-fit diagnosis and treatment

Precision Medicine

<div>
 
 Genome Medical offers cloud-based, virtual genomic services including genetic testing and counseling via its platform. The company serves both the D2C and B2B segments with a focus on therapeutic areas such as cancer, cardiovascular disease, reproductive health, pediatric genetics, pharmacogenomics, and proactive health management. Individuals attend an initial consultation with a genetic counselor to review their health history and their family's health history. Thereafter, the company will send a sample collection kit to the individual and the results will be shared with the genetic counselor, costing USD 179 per session.
 
 
 The company also partners with healthcare providers and hospitals to facilitate precision medicine programs for patients. Genome Medical&rsquo;s partners as of August 2021 included healthcare providers such as Kaiser Permanente Northwest, Renown Health, and Shriners Hospitals for Children as well as insurance providers such as United Healthcare, Cigna, and Aetna.
 
 
 In August 2021, the company raised USD 60 million in series C funding to build out its full suite of testing services and ordering capabilities. In the same month, the company acquired GeneMatters to expand its nationwide network of genetic specialists and its service offering. 
 
</div>

<div>
 
 Praxis Precision Medicines is a clinical-stage biopharmaceutical company that develops precision medicine for central nervous system disorders based on neuronal imbalance caused by genetic mutations.
 
 
 The company has four clinical-stage product candidates in its pipeline for treating disorders such as depression, epilepsy, movement disorders, and pain syndromes. The company&rsquo;s drug candidates include 1) PRAX-944, which is an inhibitor for essential tremor disorder linked to Parkinson&rsquo;s disease and is set to begin Phase 3 in mid-2023, 2) PRAX-222 in Phase 2 of clinical trials targets the SCN2A gene most commonly associated with early-onset epilepsy, 3) PRAX-562 was designed to block persistent sodium for patients suffering from rare diseases such as headache disorders and severe seizures and completed Phase 1 of clinical trials, and 4) PRAX-628 in Phase 2 clinical trials for treating focal epilepsy that originates in one side or area of the brain and affects one side of the body. Additionally, the firm has six pre-clinical drug candidates.
 
 
 Funding and financials
 
 
 The company went public in October 2020, trading on the Nasdaq Global Select Market under the ticker symbol &ldquo;PRAX&rdquo;. 
 <a href="https://sp-edge.com/updates/19453">
 In June 2023 
 </a>
 , the company announced an underwritten public offering of its common shares and pre-funded warrants, to raise approximately USD 59.1 million. The capital raised was used to support the company&rsquo;s ongoing operations and strategic initiatives, furthering the development of its pipeline and potential future endeavors.
 
 
 For the year 
 <a href="https://sp-edge.com/updates/16211">
 2022
 </a>
 , net losses increased by 28% YoY to USD 214 million arising from a significant increase in R&amp;D expense (up by 29% YoY). For the six months ended June 2023, the company is yet to generate revenue from drugs, however received collaboration revenue of USD 1.5 million. Further, it reported a decline in net loss by 43.0% YoY to USD 34.3 million. Its cash and cash equivalent as of June 2023 was at USD 124.3 million, compared to USD 61.6 million in December 2022, which the company believes will be adequate to fund operations till Q1 2025. 
 
</div>

Praxis Precision Medicines

<div>
 
 Mirati Therapeutics is a commercial-stage biotechnology company developing oncology-targeted therapies to address KRAS mutations present in 25% of tumors, including lung, colorectal and pancreatic cancers. Mirati&rsquo;s lead product KRAZATI (adagrasib/ MRTX849) is an oral&nbsp; KRASG12C inhibitor approved in 2022 for certain non-small cell lung cancers.The company also has sitravatinib, a multi-kinase inhibitor, in Phase 3 trials for non-small cell lung cancer in combination with a Bristol-Myers Squibb checkpoint inhibitor.
 
 
 
 
 Additionally, Mirati is advancing multiple early-stage programs including KRAS G12D inhibitor MRTX1133 for pancreatic and colorectal cancers, which entered Phase 1 in 2023, as well as a synthetic lethal inhibitor MRTX1719. In December 2022, the company submitted an IND application for MRTX1133, a potent and selective KRAS G12D inhibitor, which was cleared by the FDA in January 2023. 
 
 
 Key partnerships and customers
 
 
 
 
 Mirati has multiple partnerships with leading biopharma companies to advance its pipeline, including discovery collaborations with Pfizer and clinical collaborations with Novartis, Boehringer Ingelheim, and 
 <a href="https://sp-edge.com/updates/14345">
 Incyte
 </a>
 . The company also has licensing agreements with BeiGene for sitravatinib and Zai Lab for MRTX849 in certain Asian markets.
 
 
 
 
 
 Funding and Financials
 
 
 
 
 The company went public in June 2013 to trade on Nasdaq under the ticker symbol &ldquo;MRTX&rdquo;. In August 2023, the company closed an 
 <a href="https://sp-edge.com/updates/20988">
 underwritten public offering
 </a>
 at USD 345 million. The new funds were used towards drug development and leadership expansion.&nbsp;
 
 
 
 
 <a href="https://sp-edge.com/updates/16725">
 For the year 2022 
 </a>
 , the firm's net losses increased to USD 740.9 million from USD 581.8 million. Net product revenue for the full year amounted to USD 0.7 million arising from the sale of KRAZATI, which received FDA approval for its commercial launch in December 2022. 
 
</div>

Mirati Therapeutics

<div>
 
 Tvardi Therapeutics is a clinical-stage biotechnology company developing precision medicine for different cancers, chronic inflammatory diseases, and fibrotic diseases. The company&rsquo;s pipeline focuses on the development of small-molecule inhibitors of STAT3, a regulatory protein that allows cancer cells to evade the immune system and survive.
 
 
 The company&rsquo;s orally administered monotherapy and lead product, TTI-101, is in Phase 1 clinical trials for patients with advanced solid tumors who have failed all other lines of therapy. Additionally, the drug is in preclinical trials for treating fibrosis and inflammation. The company is also developing TTI-102, a next-generation STAT3 inhibitor that is structurally similar but chemically different from TTI-101.&nbsp;
 
 
 Founded in 2017, the Texas-based company closed a Series B funding round in June 2021, which brought total funding to USD 81 million and the proceeds will be used to advance Tvardi&rsquo;s drug candidates through its clinical data readouts in mid-stage trials for cancer and fibrosis.
 
</div>

Tvardi Therapeutics

<div>
 
 Tango Therapeutics is a clinical-stage biotech company developing precision oncology therapies targeting synthetic lethality in cancer which leads to cell death. Its discovery platform identifies novel targets to develop drugs focused on: 1) countering tumor suppressor gene loss to help the immune system recognize and kill cancer cells, and 2) reversing cancer cell evasion of the immune system.
 
 
 
 
 Tango has five pipeline programs, including lead candidate TNG908, an inhibitor for multiple cancer indicators. The FDA approved TNG908's IND in January 2022 and granted it Orphan Drug Designation. TNG908 is in Phase I/II trials, with preliminary efficacy data expected in H1 2023. Tango also plans to file INDs for TNG260 (STK11 mutant cancers) and TNG348 (BRCA1/2-mutant cancers). In 
 <a href="https://www.globenewswire.com/news-release/2023/01/25/2595034/0/en/Tango-Therapeutics-Announces-FDA-Clearance-of-Investigational-New-Drug-Application-for-TNG462-Provides-Additional-Business-Updates.html">
 January 2023
 </a>
 , the FDA cleared the IND for TNG462, a next-gen PRMT5 inhibitor for cancers with MTAP deletion.
 
 
 
 
 Key partnerships and customers
 
 
 
 
 
 Outside its pipeline, the company also entered into a collaborative partnership with big pharma Gilead Sciences Inc., in October 2018 which was later expanded for two years in August 2020 to identify new immune evasion targets.
 
 
 
 
 Funding and financials&nbsp;
 
 
 
 
 
 Tango went public in August 2021 via a SPAC deal, trading on Nasdaq under the ticker symbol &ldquo;TNGX&rdquo;, and the company received gross proceeds of USD 353 million. In August 2023, the company raised USD 80 million via a 
 <a href="https://sp-edge.com/updates/20955">
 private placement
 </a>
 , which was led by Nextech. The new funds were used toward expanding its TNG908 and TNG462 PRMT5 programs to various other indications.
 
 
 
 
 Tango has not yet generated any drug sales and does not expect to do so for several years. However, for the full-year the company reported collaboration revenue of USD 24.9 million (down 4.42% YoY) and a net loss of USD 108.2 million (up 85.9% YoY).
 
 
 
</div>

Tango Therapeutics

<div>
 
 IDEAYA Biosciences is a clinical-stage biotech developing precision cancer therapies based on synthetic lethality - when specific gene mutations pair to cause cell death. The company also studies combining synthetic lethality with immunotherapies and DNA damage to enhance treatment efficacy. While current drugs target limited mutations like BRCA1/2, IDEAYA aims to treat broader genetic subpopulations.&nbsp;
 
 
 
 
 Its pipeline focuses on synthetic lethality-driven precision medicines across five clinical and preclinical programs. The lead candidate, darovasertib (IDE196), is a PKC inhibitor treating metastatic uveal melanoma (MUM) with GNAQ/GNA11 mutations that lack FDA-approved therapies. The FDA granted orphan drug designation to IDE196 for MUM in May 2022. It is in Phase 2 trials. Other pipeline assets include IDE397, a Phase 2 MTAP inhibitor for solid tumors, IDE161, a Phase 1 inhibitor for cancers like ovarian and breast, and IDE705, a pol theta helicase inhibitor planned for IND submission in Q3 2023.&nbsp;
 
 
 
 
 By targeting specific genetic drivers, IDEAYA advances precision oncology using synthetic lethality approaches. The company is focused on developing novel targeted therapies for patient populations with high unmet need and limited treatment options.&nbsp;&nbsp;
 
 
 In December 2023, IDEAYA Biosciences teamed up with Gilead Sciences to test the combination of IDE397 and Trodelvy in a Phase I clinical trial for MTAP-deletion bladder cancer.
 
 
 
 
 Key partnerships and customers
 
 
 
 
 The company collaborates with pharmaceutical partners to advance its pipeline, including a strategic partnership with GSK in June 2020. The collaboration with GSK covers co-development and commercialization of two synthetic lethality programs. IDEAYA received USD 100 million upfront and USD 20 million in a direct private placement through the GSK deal. In June 2022, IDEAYA announced it would co-develop its Pol Theta candidate with GSK, with a Phase 1 trial starting in the first half of 2023.&nbsp;
 
 
 
 
 IDEAYA also holds an exclusive license from Novartis for LXS196 (IDE196), a PKC inhibitor for metastatic uveal melanoma. Additionally, the company is exploring IDE196 combinations with Pfizer and its potential in other rare skin diseases. In July 2022, IDEAYA signed an agreement with Amgen to evaluate IDE397 with Amgen's AMG 193 in solid tumors. Strategic pharma partnerships help advance and expand IDEAYA's pipeline of synthetic lethality precision oncology programs.
 
 
 
 
 Funding and financials
 
 
 
 
 
 The company was listed on the Nasdaq Global Select Market under the ticker symbol &ldquo;IDYA&rdquo; in May 2019, raising USD 50 million via an initial public offering. In September 2022, the company raised USD 92 million.&nbsp;
 
 
 
 
 For 2022, the company reported a net loss of USD 58.7 million (up 17.9% YoY) while collaboration revenue was USD 50.9 million (up 82.3% YoY). 
 
 
 On October 24, 2023, IDEAYA Biosciences priced an underwritten public offering of 5 million shares of common stock and pre-funded warrants to purchase 319,150 shares of common stock. The common stock offered was priced at USD 23.50 per share, while the exercise price of a pre-funded warrant was USD 0.0001. The offering was expected to bring in approximately USD 125 million in gross proceeds.
 
 
 
</div>

IDEAYA Bioscience

Some companies leverage AI/ML to develop tailored medication

Considers individual variability in genes, environment, and lifestyle for each person

Genomics is used across all the segments of precision medicine from diagnostic solutions to treatments

AI/ML analyzes genomic data to find drug targets, predict disease progression, and treatment response

Companies providing genetic tests to identify individuals with high risk or at-risk of having hereditary disease, aid physicians with a diagnosis, and support clinical decision making.

Companies that study intergenomic variations in genes associated with drug response and metabolism to match patients with the appropriate drug and dosage.

Genome Medical

Precision Medicine

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