LeFrak is a preeminent, family-owned property company committed to community development and long-term ownership. Its investments are geographically diverse and span many business sectors. It has significant investments in securities, private businesses, and energy.

LeFrak

Apple Core Holdings, founded in 1995, is a privately held company with investments across a range of verticals. They own and operate hotels and event spaces, and provide seed capital to hedge funds, venture capital funds, and private equity funds.  Apple Core Holdings also makes direct investments in early and mid-stage companies in a variety of fields, including Internet and mobile technologies and services, biotech, and entertainment.

Apple Core Holdings

Alpha Wave Ventures is an investment firm.

Alpha Wave Ventures

Abundance Partners was founded in 2003 as an alternative investment firm based in the Union Square area of New York City. The Firm has been an active investor in both public and private markets. While the partners of Abundance have been involved in entrepreneurial ventures for over 30 years, the firm formally began making investments in private companies in 2007.  Through multiple funds, Abundance Partners has had a significant focus on investing in early-stage enterprise technology companies. Abundance’s approach to venture investments emphasizes the building of businesses and supporting entrepreneurs through operational, sales and marketing support. Investment partners of Abundance bring a broad mix of experienced entrepreneurs, operators and investment professionals, focused on helping to build dynamic companies that create tremendous enterprise value for founders and investors.  Abundance Partners main office is located in New York, NY; the firm is opening a second office in Israel.

Abundance Partners

Life Biosciences

Life Biosciences is a developer of drugs designed to promote longevity and find treatments for age-related diseases. Developer of drugs designed to promote longevity and find treatments for age-related diseases. The company's drugs help to combat the eight pathways of age-related decline and it's work addresses health decline due to aging as a systemic breakdown of the body, rather than a series of isolated events and conditions, enabling senior citizens to tackle age-related diseases with a view to ultimately extending healthy life spans.

<div>Life Biosciences is a biotech company that develops therapeutics seeking to prevent, treat, and reverse various aging-related diseases. The company targets two biological mechanisms contributing to aging: Epigenetic alterations and loss of proteostasis. Its Epigenetic Reprogramming Platform focuses on therapies inducing the expression of three Yamanaka factors (OCT4, SOX2, and KLF4 [OSK]) to reprogram the epigenome. The company claims that this has demonstrated safety and efficacy in preclinical nerve crush and glaucoma models and, as of October 2023, this was at the preclinical stage.</div>

Longevity Tech

Forge fires up gene therapy production partnership with Life Biosciences

<div>
 
 Life Biosciences is a biotech company that develops therapeutics seeking to prevent, treat, and reverse various aging-related diseases. The company targets two biological mechanisms contributing to aging: Epigenetic alterations and loss of proteostasis. Its Epigenetic Reprogramming Platform focuses on therapies inducing the expression of three Yamanaka factors (OCT4, SOX2, and KLF4 [OSK]) to reprogram the epigenome. The company claims that this has demonstrated safety and efficacy in preclinical nerve crush and glaucoma models and, as of October 2023, this was at the preclinical stage.
 
 
 
 
 In addition, Life Biosciences' Chaperone-Mediated Autophagy Platform focuses on small molecule activators of chaperone-mediated autophagy that reduce the aggregated protein accumulation. This is claimed to have demonstrated safety and efficacy in preclinical models of neurodegeneration and retinal degeneration. As of October 2023, this was at the discovery stage.
 
 
 
 
 In October 2018, Life Biosciences acquired Lua, the communication and technology platform to utilize its technology in the development of Life Bioscience&rsquo;s platforms.&nbsp;Lua is a web and mobile-based technology platform focused on enhancing patient outcomes by facilitating communication between providers and patients.&nbsp;
 
 
 
 
 Key customers and partnerships
 
 
 
 
 In May 2023, Life Biosciences entered a manufacturing partnership with Ohio-based gene therapy development company 
 <a href="https://sp-edge.com/companies/1083510">
 Forge Biologics
 </a>
 to help advance its epigenetic reprogramming platform. Through this partnership, Forge Biologics is expected to provide adeno-associated virus (AAV) process development, toxicology, current good manufacturing practices, and analytical services to Life Biosciences. Life Biosciences will utilize Forge&rsquo;s platform processes, such as HEK293 suspension ignition cell and pEMBR adenovirus helper plasmid.
 
 
 
 
 Funding and financials
 
 
 
 
 In January 2022, Life Biosciences raised USD 82 million in a Series C funding round led by Alpha Wave Ventures. The company expected to use the funds to accelerate R&amp;D efforts toward the company&rsquo;s platforms.
 
 
 
 
 
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Mitrix Bio addresses mitochondrial dysfunction by developing bioreactor-grown mitochondria to be transplanted into the human body to regenerate organs, reverse age-related disease, and support other longevity therapies. Large-scale mitochondrial transfusion could potentially treat Alzheimer's, Parkinson's, AMD, glaucoma, infectious disease, and other age-related diseases, along with children's mitochondrial mutation diseases. The company believes that the same technique can be used in healing and reducing frailty for the aged, speeding healing of wounded soldiers, or combating aging itself. The company is developing technologies and infrastructure targeting to reverse mitochondrial mtDNA degeneration targeting parts of the body that most commonly experience mitochondrial dysfunction. The company has six programs at preclinical stages in its pipeline (as of October 2023). These programs are focused on immunology (infectious diseases), neurology (Alzheimer's/Parkinson’s), ophthalmology (AMD/glaucoma), dermatology (aking aging/wound healing), musculo-skeletal (sarcopenia, frailty), and organs (liver/kidney).

Mitrix Bio

Sierra Sciences engages in research to develop therapeutics targeting aging based on telomeres. These get shorter as people age and lead to various diseases. The company aims to extend the human lifespan and healthspan based on addressing telomere shortening as a solution to address effects of human aging. The company receives royalties from the sale of Product B, a nutraceutical supplement developed in a partnership and distributed through Isagenix. The company develops therapeutics focused on pharmaceuticals to slow and reverse the aging process, nutraceuticals to slow and reverse aging, telomere protection, telomere length measurement, cancer diagnostics, cancer treatments, telomerase gene therapy, immortal pet cloning, and human growth hormones.

Sierra Sciences

Turn.bio is a biotech company developing therapies based on epigenetic reprogramming and reverse cellular aging. The company develops mRNA medicines that induce the body to heal itself by instructing specific cells to fight disease or repair damaged tissue. This is focused on reprogramming the epigenome to restore capabilities that are often lost with age. Its proprietary ERA Platform can reportedly be used to revitalize different cells throughout the body. The company is exploring its applicability across multiple therapeutic areas, including dermatologic conditions, immunology, osteoarthritis, and ophthalmology. The platform is claimed to enable control of the time, duration, and dosage of transcription factors to optimize the mRNA cocktail for each indication. This reportedly allows control of reprogramming, moving the epigenome to a more youthful state step-by-step by carefully pulsing the cell with the transcription factors. The company claims to have discovered that the use of quiescent stem cells can significantly help to repair or replace specific types of damaged tissue. In these cases, the company reportedly deploys its Artificial Niche (AN) technology to protect the stem cells. AN technology combines stem-cell biology with biomolecular materials engineering and micro-fabrication technologies to generate novel cell-culture platforms that mimic crucial biochemical or structural aspects of the niche. turn.bio’s novel eTurna Platform can reportedly deliver a variety of cargoes requiring different routes of administration and be fine-tuned and targeted to specific tissue and cells. Funding and financials In July 2022, biotech company VitaDAO made a USD 1,000,000 investment into turn.bio. The investment was intended to fund turn.bio’s preclinical efficacy testing phase for mRNA therapeutics for dermatological and ophthalmological longevity research.

Turn.bio

<div>
 
 AgeX Therapeutics is a biotech company engaged in the development and commercialization of novel therapeutics focused on aging.&nbsp;
 
 
 
 
 The company is building upon the foundation of its proprietary technologies, such as PureStem and induced Tissue Regeneration, to develop medicines targeting aging and related diseases. Through PureStem, the company claims to have the ability to generate pluripotent stem cell-derived young cells of any type for potential application in a range of degenerative diseases of aging. iTM is claimed to be the company's longevity platform intending to unlock cellular immortality and regenerative capacity to reverse age-related changes in the body.
 
 
 
 
 Its product pipeline includes two cell-based and two iTR-based product candidates in development: AGEX-BAT1 and AGEX-VASC1.
 
 
 AGEX-BAT1 is a cell therapy product candidate in the discovery stage of development utilizing PSC-derived brown adipocytes for the treatment of certain age-related metabolic disorders, such as type 2 (adult-onset) diabetes and obesity. AGEX-VASC1 is a cell-based therapy in the discovery stage of development, composed of young regenerative vascular-forming cells.&nbsp;
 
 
 
 
 The company was founded by leading gerontologist, bioentrepreneur, and Ph.D. holder Dr. Michael D. West,&nbsp; a highly-regarded pioneer in cellular aging, stem cell research, telomerase, and cloning.
 
 
 
 
 In August 2023, the company entered a merger agreement with Serina Therapeutics, a privately held, clinical-stage biotech company developing a pipeline of therapies for the treatment of Parkinson&rsquo;s disease and other neurological diseases. Under this, Serina merged with a wholly-owned subsidiary of AgeX therapeutics in an all-stock transaction. The combined company continues under the &ldquo;Serina Therapeutics&rdquo; name and focuses on advancing Serina&rsquo;s pipeline of small-molecule drug candidates targeting central nervous systems indications.
 
 
 
 
 Funding and financials
 
 
 
 
 The company recorded total revenue of USD 34 million in 2022, compared to USD 144 million in 2021 (77% decrease). This is due to absence of grant revenues in 2022, as opposed to 2021, where grant revenue was USD 104 million. Net loss reported for 2022 was USD 10.5 million, compared to the loss of USD 8.7 million recorded in the preceding year.
 
 
 
 
 
</div>

AgeX Therapeutics

<div>
 
 UNITY Biotechnology develops therapeutics targeting age-related diseases, particularly focusing on therapy in ophthalmologic diseases, including diabetic macular edema and age-related neurologic conditions.
 
 
 
 
 Its therapeutics are intended to selectively eliminate or modulate senescent cells to slow down, stop, or even reverse age-related disease and restore aging or damaged tissue to a more functionally healthy state. The approach is expected to remedy diseases of aging, such as retinopathies, neurodegenerative disorders, fibrosis, and cancer.&nbsp;
 
 
 
 
 The company&rsquo;s lead drug candidate, UBX1325, is evaluated for the treatment of age-related diseases of the eye, including diabetic macular edema. The small molecule targets Bcl-xL, a protein that senescent cells rely on for survival. It is claimed that UBX1325 demonstrated a statistically significant and clinically meaningful improvement in mean best corrected visual acuity (BCVA) across 48 weeks compared to sham treatment in the Phase II BEHOLD study in patients with DME. A Phase IIb study (ASPIRE) was enrolling patients with DME to evaluate UBX1325 head-to-head against aflibercept.
 
 
 
 
 UNITY Biotechnology was also developing programs targeting the Tie2 signaling pathway for therapeutic benefit. Tie2 pathway activity declines with age and causes the loss of vascular barrier integrity and diseased blood vessel formation in the eye. The Tie2/VEGF bispecific molecule targets two pathways believed to be core to disease progression in DME and AMD. Another program directed at Tie2 activation is in preclinical studies for multiple indications.
 
 
 
 
 The company's neurology programs intend to explore new mechanisms for cognitive benefit, and the company licensed its &alpha;-Klotho program, UBX2089, to Jocasta Neuroscience for development and commercialization in cognitive dysfunction associated with neurological and psychiatric conditions.
 
 
 
 
 
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UNITY Biotechnology

Companies conducting R&D on cell and gene therapies that aim to repair or replace dysfunctional cells to address the root cause of age-related diseases

Companies involved in the development of novel small molecules or chemical drugs that target specific proteins or pathways in the body to treat age-related diseases as well as the identification of existing drugs that can be repurposed for the treatment of such diseases

Platforms and tools that collect and analyze patient data to detect, prevent, and monitor age-related damage

Dietary supplements and wellness products that are developed through scientific approaches to slow down age-related damage

Companies developing therapies for age-related sensory deficiencies such as vision and hearing loss

Companies in the neurotechnology sector that develop tools such as neuroimaging and neurostimulation devices; pharmaceutical drugs and therapies aimed at treating age-related neurological conditions

Diagnostic tests and services focused on assessing the health of an individual's gut microbiome and their metabolic processes to identify internal age-related issues

Platforms and tools that provide personalized remedies for general well-being and to mitigate the risk of age-related diseases

Genomics is used for diagnostics and to offer tailored treatment for age-related diseases

Offers digital platforms and devices that allow individuals to measure, track, and potentially modify the physiological changes associated with aging

AL/ML is used in drug discovery and development as well as diagnostic tools to support longevity-related treatments

Life Biosciences

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