RebelBio is the London based team of the venture capital firm SOSV. RebelBio specializes in pre-seed investments in BioTech, HealthTech & Life Sciences. It invests broadly in science-based, tech-enabled early stage startups.    RebelBio backs 16 companies per year through its 3 months investment programme. During that time founders receive pre-seed funding and hands-on support from the VC team, working closely to de-risk and fast track the growth of their companies.   After the programme, startups can get follow-on investment from RebelBio’s fund SOSV, and support to its founders over the following years.

RebelBio

SOSV is a global, deep tech venture capital firm that operates the HAX and IndieBio startup development programs focused on human and planetary health. SOSV invests $500,000 in startups at their inception as they onboard either HAX or IndieBio for a 4-6 month period designed to accelerate the raise of their next institutional round. SOSV joins the later rounds of HAX and IndieBio graduates.  HAX, based in a 35,000 sq ft facility in Newark, NJ, is equipped with machine tools, 3D printers, chemical, electrical and mechanical engineering labs, as well as on-staff engineering and design experts. SOSV's IndieBio has locations in NYC and San Francisco, both of which offer extensive services and facilities to founders including on-site BSL-2 labs, well equipped lab benches and hoods, and advanced lab equipment, such as chromatography equipment.

SOSV

Microendo

Microendo operates to protect and care for the environment. Environmental damage due to climate change poses a great risk to crop security. By harnessing the natural microbiota of the plants they develop products that are in harmony with the environment. They take the microorganisms from your own plants, identify their needs and provide you with a tailored biofertilizer. This biofertilizer is personalized to each crop, fully organic and naturally helps to increase crop health & crop yield.

Based in Mexico, Microendo offers a range of crop-specific bio-inoculants, protection products, fungicides, insecticides, and biofertilizers. The company sells biofertilizers under the brands NitrogenProtect, PhosphoProtect, and PotassiumProtect, which increase the availability of nitrogen, phosphorus, and potassium in the soil, respectively. The company's biofertilizers are made from plant-based microbes that are stated to improve the plant’s health, reduce fertilizer usage, and improve yields.

Natural Fertilizers

Based in Mexico, Microendo offers a range of crop-specific bio-inoculants, protection products, fungicides, insecticides, and biofertilizers. The company sells biofertilizers under the brands NitrogenProtect, PhosphoProtect, and PotassiumProtect, which increase the availability of nitrogen, phosphorus, and potassium in the soil, respectively. The company's biofertilizers are made from plant-based microbes that are stated to improve the plant’s health, reduce fertilizer usage, and improve yields.As of June 2022, Microendo sold its products online as well as through a network of distributors across Mexico. Microendo’s products come in 0.5 L–20 L packages with prices ranging from USD 142 to USD 7,790. Although the company has not disclosed its product reach, it reported that it was actively attracting distributors for its products via its website.Key customers and partnershipsIn <a href="https://microendo.com.mx/microendo-se-asocia-con-cooperativa-agropecuaria-para-la-distribucion-de-nuestros-biofertilizantes/">February 2024</a>, Microendo announced a strategic partnership with Cooperativa Agropecuaria to expand the distribution of its crop-specific biofertilizers throughout the country. During the same period, the company announced signing a license with <a href="https://microendo.com.mx/microendo-expande-sus-horizontes-a-colombia-en-colaboracion-con-bioest/">Bioest</a>, a Colombian company in the field of agriculture to start its operations in Colombia.

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 Based in Michigan, Gantec offers plant-based liquid fertilizers, micronutrient supplements, concentrates and biopesticides using a proprietary process called “Bio-Adaptive Supplementation” (BAS). BAS extracts properties from plants that thrive in extreme environments such as the neem tree and converts them into fertilizers. Gantec’s products can be applied to a range of crops, including field crops, root crops, vegetables, and tree and bush crops. The company initially began sourcing its raw materials from West Africa, and, as of May 2022,  sourced it from six continents.  
 
 
 Gantec’s BAS solutions claim to improve plant resiliency, nutrient uptake, yield, and growth. For instance, based on a trial conducted by the Saginaw Valley State University, applying the company’s GantecPro liquid fertilizer to cherry tomatoes increased the yield by 17%. For potatoes, based on another trial conducted by the Michigan State University, applying GantecPro increased the yield by 11%. 
 
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Gantec Inc

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 Based in Washington, Impact Bioenergy manufactures portable systems that convert organic waste to produce electricity and fertilizer. The company started manufacturing its own biofertilizer product called “ProBiotic Plant Food” (PBF)  in July 2020. PBF is a compost biofertilizer, which is made by first creating a “smoothie” from waste food such as spent yeast, curds, whey, and trub. This is then digested by microbes in a 30-day process to convert it into PBF. The final product is dried and pulverized to create a mix called “PBF Mix No 7.” Based on a trial conducted by Forest Garden Farm for a butternut squash tree, PBF increased yields by almost 30% compared to using a standard fertilizer. 
 
 
 The company also adds fish bone meal, poultry feather meal, biochar, and mealworm frass to the base product to produce different blends of PBF, which is offered as a dry blend or concentrated liquid blend that can be mixed with water to make a fertigation liquid. PBF initially was available to B2B customers on a subscription basis and then later targeted B2C customers selling online via ecommerce sites such as Amazon.  
 
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Impact bioenergy

Based in France, Toopi Organics converts human urine (which is naturally high in nitrogen, phosphorus, and potassium) into fertilizer called “BACTIPI" using a proprietary patented fermentation process. The process involves collecting and filtering ‘pure’ urine (not mixed with water) from public places including schools, stadiums, and amusement parks before fermentation. The company ferments the cleaned urine at its production facility in Loupiac de la Réole France using 5,000 liter fermentation tanks along with sugar and Lactobacillus paracasei lactic bacteria to create a 100% organic fertilizer.“BACTIPI” can be applied to field crops, vine crops, home gardening, and industrial crops and promotes the growth of microorganisms and solubilizes phosphorus in the soil, increasing plant and root growth. The company has demonstrated that its fertilizer has similar efficiency and is a cheaper alternative to other chemical fertilizers in the market.Toopi aims to partner with local companies including farmers, fertilizer distributors, and sanitation companies to set up and operate urine processing plants. Toopi will handle the production of the fertilizer, while the partnering company will handle distribution. As of May 2022, Toopi states had set up a subsidiary in Belgium and was actively working with companies in Benin and Kenya to commercialize its products. The company had also signed an agreement with a large fertilizer distributor in France (name undisclosed) to sell its fertilizer for the following three years. Toopi has received approval to sell its products in Belgium and expects to obtain the same in France in 2022.Financials and Funding:In <a href="https://techfundingnews.com/french-startup-toopi-organics-raises-95m-to-turn-human-urine-into-crop-biostimulants/">November 2023</a>, Toopi Organics raised EUR 8.4 million (~USD 9 million) from EIC Accelerator, a European innovation programme for deep tech startups. The funding comprises a EUR 2.4 million non-dilutive grant and EUR 6 million in equity to be invested in 2025. Also, in <a href="https://techfundingnews.com/french-startup-toopi-organics-raises-95m-to-turn-human-urine-into-crop-biostimulants/">September 2023</a>, the company raised EUR 16 million (~USD 17 million) in funding to expand its urine collection network.&nbsp;Previously, In <a href="https://www.eu-startups.com/2021/04/bordeaux-based-toopi-organics-scales-up-urine-recycling-network-in-france-with-e3-8-million-funding">April 2021</a>, The company received a EUR 3.8 million (~USD 4.1 million) grant from ADEME (The French Agency for Ecological Transition). The company planned to use the funds to build a network of urine recycling plants in partnership with toilet manufacturers, installers, and collectors.

Greentech TOOPI Organics

Reazent is a Canadian company that has developed a patented technology to organically replace agrochemicals. The company focuses on loading plant growth-promoting rhizobacteria (PGPRs) to treat the soil and the plant. The company states that its technology can be applied across a wide range of crops such as soybean, peanuts, wheat, kale, and lettuce.Studies show that only 0.1% PGPR strains have been commercialized to date. Reazent claims that its competitive advantage is that it can work with up to 116 PGPR strains and has identified that soil bacteria have a second metabolite that can be used to up-regulate plant defense and root growth genes in plants. The company further claims that its technology helps in achieving an improvement of 5x in the plant’s immune system, thereby providing protection against pesticides as well.As of June 2022, the company has not commercialized and is actively working on obtaining regulatory approval for the sale of its products in Canada and the US. Based on trials conducted in 2020 across different growing conditions, its product has demonstrated a 400% increase in soybean root nodules, a 30% increase in peanuts above-ground biomass, and up to a 35% increase in peanuts pod dry weight when compared with synthetic and other organic products. In October 2020, the company reported that it had many trials underway, including for tomato, and was expecting results by December 2021. The company noted in November 2021 that it would be extensively trialing its fertilizer product for soybeans in North America, Brazil, and India during the following growing season.Funding and financialsIn May 2020, the company received CAD 350,000 (USD 250,000) in seed funding as part of joining IndieBio’s accelerator program. The funds were to be used to conduct trials for its prototype fertilizer product at the <a href="http://www.verschurencentre.ca/">Verschuren Center for Sustainability in Energy and the Environment </a>at Cape Breton University ass well as to develop its product for large-scale trials. In <a href="https://crushdynamics.com/news/natural-products-canada-supports-over-4m-in-commercialization-activity-for-seven-promising-canadian-food-and-agriculture-companies/">February 2023</a>, the company raised USD 15,600 from Natural Products Canada, a non-profit organization that supports Canadian bio-based innovation and commercialization to fast-track the development of a regulatory plan.

Reazent

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 Based in Spain, Ficosterra is a marine biotechnology company that offers seaweed and algae-based fertilizers and biostimulants, with applications in agriculture, landscaping, and turf. The company offers fertilizer under the brands “Ficosterra-g” (algae-based) and “Ficosgreen” (algae and seaweed-based), made using its “Biological Crop Booster” (BCB) technology. BCB combines microbes and algae extracts to produce soil-regenerating microbes.
 
 
 As of June 2022, Ficosterra operated two manufacturing facilities in Mexico and Spain and sold its products via its own online store, serving the local and overseas markets (launched across the US and Europe in 2019). 
 
 
 To expand the reach of its products in Spain, in October 2018, the company partnered with Sipcam Jardin, a Spanish multinational distributor of fertilizers, nutrients, and biostimulants, for the distribution of “Ficosterra-g,” Ficosterra’s algae-based fertilizer. In January 2021, Ficosterra also partnered with Algas Marinas (AlgaMar), a Mexico-based company producing algae-based products for agriculture and human consumption, to jointly launch “Ficosterra America,” which would serve both the American and European markets. Ficosterra and AlgaMar were to combine their seaweed and algae nutrient-extracting technologies to develop and produce fertilizer.
 
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Focisterra

Contain bacteria such as Rhizobia, Azotobacter, Azospirillum, and blue-green algae that transform nitrogen into organic compounds that can be absorbed by the plant

Contain bacteria and fungi capable of breaking down insoluble phosphates to make them available to crops

Contain rhizobacteria that can act as biofertilizers, bioprotectants

Contain organic matter such as animal dung which enriches the soil with microorganisms

Fertilizers derived from animal materials such as cow manure, crushed animal bones, animal blood, shellfish, and fish meal

Fertilizers made with plant material such as compost produced from plant waste, seaweed, cottonseed meal, and soybean meal

Fertilizers developed from natural elements like greensand, rock phosphate, and nitrogen from air

Provides a natural alternative to chemical fertilizers

Microendo

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