Alpenglow Biosciences

Alpenglow Biosciences is a venture-backed company focused on developing AI-enabled 3D imaging technology for spatial biology applications. The company's platform provides end-to-end 3D spatial biology solutions, including patented high-throughput 3D imaging, cloud-based GPU-accelerated bioinformatics pipelines, and AI-powered spatial analysis. Alpenglow's technology non-destructively digitizes entire tissue samples at subcellular resolution, generating up to 250 times more data than traditional slide-based pathology methods. This approach allows for the analysis of complex tissue architectures and intercellular distributions that can only be visualized in three dimensions.

The company's flagship product, the 3Deep Imager (3Di), rapidly digitizes entire tissue blocks without cutting slides, preserving samples for downstream assays. Alpenglow's platform also includes the 3Dm cloud-based data management system and the 3Deep Analysis (3Da) suite, which uses AI and machine learning algorithms to interpret 3D data. In August 2023, Alpenglow was awarded a USD 1.6 million grant to develop AI-enabled smart microscopy using its multi-resolution 3Di platform. The company is incorporating NVIDIA Holoscan and IGX technologies to enable AI edge computing and rapid processing of large microscopy datasets.

Key customers and partnerships

Alpenglow Biosciences partners with pharmaceutical companies to accelerate drug development through improved understanding of mechanism of action, efficacy, toxicology, and patient trial enrollment. Five of the top 10 pharmaceutical companies were working with Alpenglow as of June 2022. In April 2023, Alpenglow announced a collaboration with Mayo Clinic to integrate its 3D spatial biology platform for drug development and clinical diagnostics applications. The company also partnered with CorePlus, a CLIA-certified laboratory in Puerto Rico, in October 2022 to implement its 3D spatial biology platform for clinical research and development. This collaboration aims to create a 3D database of prostate biopsies and develop AI models for recognizing key tissue structures in cancer samples.