We back visionary founders who are building technologies of the future. 2048 Ventures is a thesis-driven earliest stage venture capital firm. We are founders, experienced operators, nerds and dreamers obsessed with the future. We've backed over 200 startups and have the experience and conviction to lead your pre-seed or seed round. We get you and your vision before others. We are systems thinkers, engineers, and product junkies. We think about the future non-stop and are ready to understand and back you before anyone else. When we decide to invest, we write you a check and then help you close the rest of the round. We lead rounds with high conviction, and write $500K - $2M checks.

2048 Ventures

Y Combinator is a startup accelerator that provides funding and mentorship to early-stage companies. It offers a program where startups receive guidance from experienced entrepreneurs and investors. The organization helps founders in their business models and develop their products. Y Combinator serves industries such as technology, healthcare, and finance.

Y Combinator

Real Ventures is an early-stage venture firm focused on serving daring entrepreneurs with the ambition to create successful, global companies. Since 2007, Real Ventures has dedicated itself to building the Canadian startup ecosystem on the belief that people, not money, build game-changing companies. Real Ventures provides stage-specific guidance, mentorship, and access to networks and resources to fast-track founders’ personal and company growth. Real Ventures manages $325 million across five funds and its active portfolio of 100+ companies is currently valued at $10 billion. www.realventures.com

Real Ventures

First Star partners with entrepreneurs solving real-world problems using data and machine learning, focusing on applications of frontier technologies such as AI, computational biotech, connected sensors, AR/VR, and blockchain. We believe in investing with conviction in visionary, technical founders inventing the future. Drawing on our experience and network of strategic partners across industries and regions, we help startups think big and grow fast.

First Star Ventures

Creative Destruction Lab (CDL) is a no-fee/no-equity organization that delivers an objectives-based mentoring program for massively scalable, pre-seed stage, science- and technology-based companies. Its nine-month program allows founders to learn from experienced entrepreneurs, increasing their likelihood of success. Founded in 2012 by Professor Ajay Agrawal at the University of Toronto’s Rotman School of Management, the program has expanded to thirteen sites across seven countries: Seattle, Oxford, Paris, Atlanta, Estonia, Wisconsin, Vancouver, Calgary, Montreal, Berlin, Melbourne and Halifax.

Creative Destruction Lab (CDL)

BoxOne Ventures is a privately held investment firm that focuses on early-stage companies across all markets: biotech, fintech, agtech, healthcare, data, engineering, and AI/ML. We strive to balance the best elements of patient angel capital with the value-add often found at venture funds. You will often find us as the first cheque into a company. We invest our own capital and bring our experience as operators that have scaled many startups from founding to exit. We like partnering in the earliest days and continuing to support entrepreneurs with capital, expertise, and our network across their entire journey while making sure to never get in their way.

BoxOne Ventures

TechU invests in platform technologies that harness complex science and engineering breakthroughs for enduring global impact. We write patient checks that propel technologists with early capital and knowledgeable support. We scour the world’s leading universities, labs, and research centers for emerging technologies with wide-reaching implications, structured to maximize lasting impact over momentary returns. Our interest spans continents and categories in search of transformative technology that generates distinct competitive advantages. At the helm are experienced entrepreneurs who contribute hard-earned funds and hard-won expertise to deliver the holistic support deep tech pioneers require. In short, we search for the foundations of our collective future.

TechU Ventures

Lux Capital manages over $5 billion in assets focused on founding, seed, early-stage, and growth investments at the intersection of technology and the sciences. Lux takes an active role in helping entrepreneurs build successful businesses in high-growth sectors. Its investment team has built over 20 companies from scratch. Lux's investment strategy ensures portfolio companies are better connected, have a deeper insight, and command industry leadership faster than their competitors.

Lux Capital

SR One is the corporate venture capital arm of GlaxoSmithKline. The firm invests globally in emerging life science companies that are pursuing innovative science which will significantly impact medical care. Since 1985, SR One has invested approximately 800 million in more than 180 companies.

SR One

Casdin Capital is a fundamental research investment firm focused on the life sciences and healthcare industry. It manages a long-short equity fund and makes investments in early-stage to late-stage private investments.  Casdin was launched in 2012 by founder and CIO Eli Casdin and as of October 2020 has approximately $2.2 billion in assets under management.

Casdin Capital

Collaborative venture capital to accelerate disruptive technological innovation in AI, data, analytics, fintech, ad tech, DevOps, mobility, aerospace, and infrastructure. They have worked with and invested in visionaries, category killers, disruptors, and inventive leaders. They collaborate with businesses that are disrupting big industries. Help them expand and hyper-accelerate by using a collective ''operators for operators'' approach to scaling.

Trajectory Ventures

Amplitude Venture Capital deploys a growth model that has successfully been used to build Canadian companies with world-class management teams and scale companies to breakout potential. Since 2012 Amplitude's founding team has raised over $700 million of equity capital in private and public markets. Amplitude, with offices in Montreal, Toronto, and Vancouver, launched its first private capital fund in November 2019, a $200-million fund that applies a proven, evidence-based approach to investing in leading Canadian precision medicine companies.

Amplitude Venture Capital

Early stage and growth equity investments in Life Sciences, TechBio, Healthtech and Diagnostics. There is enormous opportunity in the life sciences, tech bio and healthtech spaces across all investment stages. The next medical breakthroughs will come from combining incredible new technologies with a greater understanding of biology. AVANT BIO LLC was launched to invest in these opportunities and was structured to attract institutional capital interested in these spaces.

Avant Bio

Nomic

Nomic is a bioengineering company working to make the human proteome as broadly and easily accessible as the human genome. They are building the nELISA, a next-generation ELISA platform for measuring proteins at scale and at high throughput. They offer scientists protein profiling solutions to empower them to decide the scope and scale of their experiments.

Nomic Bio is a protein profiling company that has developed a proprietary platform, nELISA, which enables massive multiplexing with flexibility, full quantification, and cost-efficiency in protein measurement. Nomic's technology aims to change how drugs are developed and how diseases are diagnosed by providing a comprehensive solution for inflammation research that allows the high-throughput quantification of hundreds of secreted proteins.&nbsp;

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Nomic Networks

The Protein Profiling Company

Leveraging personal data for custom-fit diagnosis and treatment

Precision Medicine

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Nomic, founded in 2017 and based in Montreal, Canada, is a pioneering protein profiling company that has developed a high-throughput platform called nELISA. This innovative technology aims to revolutionize the traditional ELISA (enzyme-linked immunosorbent assay) method by incorporating DNA nanotechnology, automation tools, and spectral multiplexing. The nELISA platform reduces the size of ELISA components into micro-sized beads, enabling the simultaneous profiling of hundreds of proteins. This approach significantly reduces the turnaround time and cost compared to conventional ELISA tests.
The company's mission is to improve human health by providing scientists with tools to measure proteins at high resolution and unprecedented scale and cost. This enables better decision-making on targets, drugs, and biomarkers. Nomic's technology addresses several industry bottlenecks in a scalable and versatile manner, making proteomic information more broadly and easily accessible for biomedical scientists.
Nomic's nELISA platform uses pairs of target-specific antibodies assembled at the surface of every bead. Target proteins are identified by capture and detection antibodies, forming a sandwich complex. The detection antibody, bound to the bead, is labeled with a fluorescent dye. This process allows researchers to profile proteins faster and more precisely while using a simple workflow based on commercially available instrumentation.

Nomic Bio is a protein profiling company that has developed a proprietary platform, nELISA, which enables massive multiplexing with flexibility, full quantification, and cost-efficiency in protein measurement. Nomic's technology aims to change how drugs are developed and how diseases are diagnosed by providing a comprehensive solution for inflammation research that allows the high-throughput quantification of hundreds of secreted proteins.&nbsp;The nELISA platform miniaturizes immunoassays into small beads, isolating target-specific antibody pairs to their own color-coded beads, which prevents cross-reactive interactions and allows highly specific results at a fraction of the time and cost of traditional methods. As of September 2024, Nomic had profiled more than 25 million proteins. Also, the company was expanding its biological footprint to cover proteins across the entire proteome, aiming to unlock new possibilities for diverse applications, use cases, and disease areas.&nbsp;Key customers and partnershipsAs of September 2024, Nomic had served over 75 companies, including top 10 pharmaceutical companies, biotechs, and research institutes.Nomic Bio's customer base spans various sectors of the life sciences industry, profiling over 400,000 samples using Nomic's technology. The company's platform has been employed across different areas of biomedical research and pharmaceutical development.

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 Praxis Precision Medicines is a clinical-stage biopharmaceutical company that develops precision medicine for central nervous system disorders based on neuronal imbalance caused by genetic mutations.
 
 
 The company has four clinical-stage product candidates in its pipeline for treating disorders such as depression, epilepsy, movement disorders, and pain syndromes. The company&rsquo;s drug candidates include 1) PRAX-944, which is an inhibitor for essential tremor disorder linked to Parkinson&rsquo;s disease and is set to begin Phase 3 in mid-2023, 2) PRAX-222 in Phase 2 of clinical trials targets the SCN2A gene most commonly associated with early-onset epilepsy, 3) PRAX-562 was designed to block persistent sodium for patients suffering from rare diseases such as headache disorders and severe seizures and completed Phase 1 of clinical trials, and 4) PRAX-628 in Phase 2 clinical trials for treating focal epilepsy that originates in one side or area of the brain and affects one side of the body. Additionally, the firm has six pre-clinical drug candidates.
 
 
 Funding and financials
 
 
 The company went public in October 2020, trading on the Nasdaq Global Select Market under the ticker symbol &ldquo;PRAX&rdquo;. 
 <a href="https://sp-edge.com/updates/19453">
 In June 2023 
 </a>
 , the company announced an underwritten public offering of its common shares and pre-funded warrants, to raise approximately USD 59.1 million. The capital raised was used to support the company&rsquo;s ongoing operations and strategic initiatives, furthering the development of its pipeline and potential future endeavors.
 
 
 For the year 
 <a href="https://sp-edge.com/updates/16211">
 2022
 </a>
 , net losses increased by 28% YoY to USD 214 million arising from a significant increase in R&amp;D expense (up by 29% YoY). For the six months ended June 2023, the company is yet to generate revenue from drugs, however received collaboration revenue of USD 1.5 million. Further, it reported a decline in net loss by 43.0% YoY to USD 34.3 million. Its cash and cash equivalent as of June 2023 was at USD 124.3 million, compared to USD 61.6 million in December 2022, which the company believes will be adequate to fund operations till Q1 2025. 
 
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Praxis Precision Medicines

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 Mirati Therapeutics is a commercial-stage biotechnology company developing oncology-targeted therapies to address KRAS mutations present in 25% of tumors, including lung, colorectal and pancreatic cancers. Mirati&rsquo;s lead product KRAZATI (adagrasib/ MRTX849) is an oral&nbsp; KRASG12C inhibitor approved in 2022 for certain non-small cell lung cancers.The company also has sitravatinib, a multi-kinase inhibitor, in Phase 3 trials for non-small cell lung cancer in combination with a Bristol-Myers Squibb checkpoint inhibitor.
 
 
 
 
 Additionally, Mirati is advancing multiple early-stage programs including KRAS G12D inhibitor MRTX1133 for pancreatic and colorectal cancers, which entered Phase 1 in 2023, as well as a synthetic lethal inhibitor MRTX1719. In December 2022, the company submitted an IND application for MRTX1133, a potent and selective KRAS G12D inhibitor, which was cleared by the FDA in January 2023. 
 
 
 Key partnerships and customers
 
 
 
 
 Mirati has multiple partnerships with leading biopharma companies to advance its pipeline, including discovery collaborations with Pfizer and clinical collaborations with Novartis, Boehringer Ingelheim, and 
 <a href="https://sp-edge.com/updates/14345">
 Incyte
 </a>
 . The company also has licensing agreements with BeiGene for sitravatinib and Zai Lab for MRTX849 in certain Asian markets.
 
 
 
 
 
 Funding and Financials
 
 
 
 
 The company went public in June 2013 to trade on Nasdaq under the ticker symbol &ldquo;MRTX&rdquo;. In August 2023, the company closed an 
 <a href="https://sp-edge.com/updates/20988">
 underwritten public offering
 </a>
 at USD 345 million. The new funds were used towards drug development and leadership expansion.&nbsp;
 
 
 
 
 <a href="https://sp-edge.com/updates/16725">
 For the year 2022 
 </a>
 , the firm's net losses increased to USD 740.9 million from USD 581.8 million. Net product revenue for the full year amounted to USD 0.7 million arising from the sale of KRAZATI, which received FDA approval for its commercial launch in December 2022. 
 
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Mirati Therapeutics

<div>
 
 Tvardi Therapeutics is a clinical-stage biotechnology company developing precision medicine for different cancers, chronic inflammatory diseases, and fibrotic diseases. The company&rsquo;s pipeline focuses on the development of small-molecule inhibitors of STAT3, a regulatory protein that allows cancer cells to evade the immune system and survive.
 
 
 The company&rsquo;s orally administered monotherapy and lead product, TTI-101, is in Phase 1 clinical trials for patients with advanced solid tumors who have failed all other lines of therapy. Additionally, the drug is in preclinical trials for treating fibrosis and inflammation. The company is also developing TTI-102, a next-generation STAT3 inhibitor that is structurally similar but chemically different from TTI-101.&nbsp;
 
 
 Founded in 2017, the Texas-based company closed a Series B funding round in June 2021, which brought total funding to USD 81 million and the proceeds will be used to advance Tvardi&rsquo;s drug candidates through its clinical data readouts in mid-stage trials for cancer and fibrosis.
 
</div>

Tvardi Therapeutics

<div>
 
 Tango Therapeutics is a clinical-stage biotech company developing precision oncology therapies targeting synthetic lethality in cancer which leads to cell death. Its discovery platform identifies novel targets to develop drugs focused on: 1) countering tumor suppressor gene loss to help the immune system recognize and kill cancer cells, and 2) reversing cancer cell evasion of the immune system.
 
 
 
 
 Tango has five pipeline programs, including lead candidate TNG908, an inhibitor for multiple cancer indicators. The FDA approved TNG908's IND in January 2022 and granted it Orphan Drug Designation. TNG908 is in Phase I/II trials, with preliminary efficacy data expected in H1 2023. Tango also plans to file INDs for TNG260 (STK11 mutant cancers) and TNG348 (BRCA1/2-mutant cancers). In 
 <a href="https://www.globenewswire.com/news-release/2023/01/25/2595034/0/en/Tango-Therapeutics-Announces-FDA-Clearance-of-Investigational-New-Drug-Application-for-TNG462-Provides-Additional-Business-Updates.html">
 January 2023
 </a>
 , the FDA cleared the IND for TNG462, a next-gen PRMT5 inhibitor for cancers with MTAP deletion.
 
 
 
 
 Key partnerships and customers
 
 
 
 
 
 Outside its pipeline, the company also entered into a collaborative partnership with big pharma Gilead Sciences Inc., in October 2018 which was later expanded for two years in August 2020 to identify new immune evasion targets.
 
 
 
 
 Funding and financials&nbsp;
 
 
 
 
 
 Tango went public in August 2021 via a SPAC deal, trading on Nasdaq under the ticker symbol &ldquo;TNGX&rdquo;, and the company received gross proceeds of USD 353 million. In August 2023, the company raised USD 80 million via a 
 <a href="https://sp-edge.com/updates/20955">
 private placement
 </a>
 , which was led by Nextech. The new funds were used toward expanding its TNG908 and TNG462 PRMT5 programs to various other indications.
 
 
 
 
 Tango has not yet generated any drug sales and does not expect to do so for several years. However, for the full-year the company reported collaboration revenue of USD 24.9 million (down 4.42% YoY) and a net loss of USD 108.2 million (up 85.9% YoY).
 
 
 
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Tango Therapeutics

<div>
 
 IDEAYA Biosciences is a clinical-stage biotech developing precision cancer therapies based on synthetic lethality - when specific gene mutations pair to cause cell death. The company also studies combining synthetic lethality with immunotherapies and DNA damage to enhance treatment efficacy. While current drugs target limited mutations like BRCA1/2, IDEAYA aims to treat broader genetic subpopulations.&nbsp;
 
 
 
 
 Its pipeline includes synthetic lethality-driven precision medicines across four potential first-in-class clinical-stage product candidates. Of these, the company owns/controls commercial rights of the three most-advanced of these product candidates: darovasertib, IDE397, and IDE161. As of May 2024, the company was also advancing Werner Helicase program for which a development candidate has been selected in collaboration with GlaxoSmithKline, and, subject to investigational new drug-, or IND-, enabling studies, are targeting an IND in 2024. In addition. the company also works on multiple earlier-stage preclinical programs. 
 
 
 By targeting specific genetic drivers, IDEAYA advances precision oncology using synthetic lethality approaches. The company is focused on developing novel targeted therapies for patient populations with high unmet need and limited treatment options.&nbsp;&nbsp;
 
 
 In December 2023, IDEAYA Biosciences teamed up with Gilead Sciences to test the combination of IDE397 and Trodelvy in a Phase I clinical trial for MTAP-deletion bladder cancer.
 
 
 
 
 Key partnerships and customers
 
 
 
 
 The company collaborates with pharmaceutical partners to advance its pipeline, including a strategic partnership with GSK in June 2020. The collaboration with GSK covers co-development and commercialization of two synthetic lethality programs. IDEAYA received USD 100 million upfront and USD 20 million in a direct private placement through the GSK deal. In June 2022, IDEAYA announced it would co-develop its Pol Theta candidate with GSK, with a Phase 1 trial starting in the first half of 2023.&nbsp;
 
 
 
 
 IDEAYA also holds an exclusive license from Novartis for LXS196 (IDE196), a PKC inhibitor for metastatic uveal melanoma. Additionally, the company is exploring IDE196 combinations with Pfizer and its potential in other rare skin diseases. In July 2022, IDEAYA signed an agreement with Amgen to evaluate IDE397 with Amgen's AMG 193 in solid tumors. Strategic pharma partnerships help advance and expand IDEAYA's pipeline of synthetic lethality precision oncology programs.
 
 
 
 
 Funding and financials
 
 
 
 
 
 The company was listed on the Nasdaq Global Select Market under the ticker symbol &ldquo;IDYA&rdquo; in May 2019, raising USD 50 million via an initial public offering. In September 2022, the company raised USD 92 million.&nbsp;
 
 
 
 
 For 2022, the company reported a net loss of USD 58.7 million (up 17.9% YoY) while collaboration revenue was USD 50.9 million (up 82.3% YoY). 
 
 
 On October 24, 2023, IDEAYA Biosciences priced an underwritten public offering of 5 million shares of common stock and pre-funded warrants to purchase 319,150 shares of common stock. The common stock offered was priced at USD 23.50 per share, while the exercise price of a pre-funded warrant was USD 0.0001. The offering was expected to bring in approximately USD 125 million in gross proceeds.
 
 
 
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IDEAYA Biosciences

Companies providing genetic tests to identify individuals with high risk or at-risk of having hereditary disease, aid physicians with a diagnosis, and support clinical decision making.

Secure cloud-based platforms and data sharing networks that collect, index, store, and analyze large amounts of health data and patient population data sets from sources including genomic, clinical, wearables, imaging, and population data.

Biopharma and biotechnology companies that develop precision medicine drugs based on novel disease biomarkers present in multi-omic patient population data and genetic insights.

Companies that study intergenomic variations in genes associated with drug response and metabolism to match patients with the appropriate drug and dosage.

Companies that develop an in-vitro medical device or imaging tools and tests that identify genetic mutations for both diagnostic (nature of the disease) and prognostic (likely course of the disease) purposes, allowing providers to match a patient to a specific drug or therapy.

Software analytics platforms that integrate multiple omics datasets (genomics, transcriptomics, proteomics, and metabolomics) to gain insights and support target discovery, drug development, clinical trials, and diagnostics.

Some companies leverage AI/ML to develop tailored medication

Considers individual variability in genes, environment, and lifestyle for each person

Genomics is used across all the segments of precision medicine from diagnostic solutions to treatments

AI/ML analyzes genomic data to find drug targets, predict disease progression, and treatment response

<div>
 
 Protein profiling firm Nomic Bio secured USD 42 million in a Series B funding round, which saw contributions from a number of investors including Amplitude Ventures, AVANT BIO, Lux Capital, Real Ventures, and SR One. The round was oversubscribed and led by a US investor specializing in life sciences.
 With the new funding, Nomic plans to grow its commercial operations and invest in its protein profiling platform, ELISA. In addition, the company plans to expand its array of services.
 Operational from Canada, Nomic Bio is a key developer of the nELISA platform. This technology facilitates quantitative profiling of secretome and is utilized by various pharmaceutical and biotech companies as well as research institutions. Its design is aimed at addressing pressing issues in proteomics research.
 
</div>

Nomic

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