Upfront Ventures is proud to be an early investor and long-term partner to the most exciting founders and startups. Founded in 1996 in Los Angeles with investing professionals based in LA, San Francisco, and Paris, Upfront has backed standout teams across all technology sectors, including Ring (acq. by Amazon), TrueCar (NASDAQ: TRUE), Bird, Maker Studios (acq by Disney), GOAT, Apeel Sciences, thredUP, Invoca and Kyriba (acq by Bridgepoint). We invest about half of our capital in the fast-growing Southern California ecosystem, with the balance across the country as well as investments in Europe and Israel. Upfront Ventures is led by Managing Partners Yves Sisteron, Mark Suster, and Kara Nortman.

Upfront Ventures

Each Founder Collective partner has founded and sold a technology company. The company we wish had existed when we first started out is what we hope to create with Founder Collective. We offer a user guide for managing the risky commodity known as venture capital. The company believes that in order to advance their firms and maintain control, entrepreneurs should aim to raise the least amount of money possible. Founder Collective was established on May 22, 2009 in Cambridge, Massachusetts.

Founder Collective

M13 provides strategic counsel and operational expertise to help founders grow their companies. Through Fund II, M13 will expand its focus to emerging technologies driving change in consumer behavior over the next decade.   Founded in 2016 with offices in Los Angeles, New York, and San Francisco.

Inflect Health is Optimized and accessible for all.

Inflect Health

Ayble Health

Ayble is a clinically-backed digital health platform that uses data-driven machine learning technology to provide comprehensive, precision dietary analysis and holistic care for people with GI conditions.

Chronic care management company Ayble Health is developing a virtual care platform for patients with digestive diseases such as irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). The company claims 81% of patients who used the platform have improved their IBS and IBD symptoms.&nbsp;

Membership-based, non-insurance healthcare companies helping maintain a steady state of well being.

Preventive Healthcare

Chronic care management company Ayble Health is developing a virtual care platform for patients with digestive diseases such as irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). The company claims 81% of patients who used the platform have improved their IBS and IBD symptoms.&nbsp;In April 2023, the company launched its D2C app focused on chronic gastrointestinal (GI) conditions. The platform connects patients to expert dietitians who will provide one-to-one care with personalized nutrition plans for 12–16 weeks to improve symptoms. In addition, the platform includes educational tools and resources.Key customers and partnershipsThe company underwent clinical research in seven academic research institutions, including Mayo Clinic, Cleveland Clinic, and the University of Washington. In <a href="https://sp-edge.com/updates/24346">November 2023</a>, the company partnered with Mayo Clinic to provide a combined virtual and in-person care model for patients with chronic GI conditions.&nbsp;Funding and financialsThe company raised USD 4.6 million in a seed funding round in <a href="https://sp-edge.com/updates/14760">November 2022</a>, co-led by Upfront Ventures and M13. The new funds were allocated toward clinical research, commercialization, and the development of an ML-driven psychology program.

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 Cardiomo Care offers noninvasive wearable devices to alert users and caretakers when there are abnormalities in the heartbeat. The device can also conduct real-time wireless ECGs, track skin temperature, and detect falls. It also leverages AI to predict potential heart problems using cardiac signals.
 
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Cardiomo Care

Omada is a prevention-focused digital therapeutics startup that helps members achieve health goals through lifestyle changes. It offers five evidence-based, virtual prevention programs for managing hypertension, behavioral health, musculoskeletal (MSK) issues, obesity and prediabetes, and diabetes.&nbsp;Omada offers real-time data tracking through connected devices (such as wireless scales, blood pressure, and glucose monitors) and access to personalized coaching sessions via a mobile app as part of its prevention program. It also provides an online community of peers with similar health conditions to discuss challenges and provide support. In May 2021, Omada became the first fully-virtual healthcare provider to earn the National Committee for Quality Assurance’s Population Health Program Accreditation for its type 2 diabetes and type 2 diabetes + hypertension programs.Unlike its peers, Omada operates a performance-based business model where it charges clients an enrollment fee based on the number of users and a performance fee based on how much weight their employees lose.&nbsp; By February 2022, Omada had more than 550,000 members from more than 1,700 enterprise clients across all 50 US states.&nbsp;Key Customers and PartnershipsIts B2B employer and health plan client base include key clients such as American Eagle, Kaiser Permanente, Costco Wholesale, 3M, and Marvin. Additionally, the company has partnered with health systems and hospitals such as Intermountain Healthcare to provide its preventive programs as a covered benefit. In <a href="https://sp-edge.com/updates/15587">January 2023</a>, the company partnered with health service company Castell (a subsidiary of Intermountain Healthcare) to provide its diabetes programs to members from Intermountain Healthcare’s primary care providers in its Utah Medical Group. Further in <a href="https://sp-edge.com/updates/25245">January 2024</a>, the company partnered with Amazon to expand access to its cardiometabolic program.&nbsp;In May 2020, the company purchased virtual physical therapy startup Physera.&nbsp;Funding and FinancialsIn <a href="https://sp-edge.com/updates/8703">February 2022</a>, Omada concluded a USD 192 million Series E funding round to hire more employees, further expand its offerings, as well as to invest in its Omada Insights Lab, which uses health data for better chronic care delivery.

Omada Health

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 VillageMD is a provider of primary care services for patients. It also provides tools, technology, and staffing support needed for physicians to deliver high-quality services. VillageMD&rsquo;s service delivery methods include traditional freestanding clinics, Village Medical at Walgreens co-located clinics, as well as at-home and around-the-clock virtual visits. It also leverages a team-based approach to care where physicians lead nurse practitioners, pharmacists, mental health specialists, and dietitians to offer a holistic care program. The technology of VillageMD includes docOS, an operating system that enables better patient care by connecting various clinical source systems with ongoing patient-generated data coupled with an AI engine to continuously analyze messages to enable patient self-care.
 
 
 The company carried out two major acquisitions in 2022, including the acquisition of chronic care management company Healthy Interactions, healthcare provider Summit Health. Summit Health&rsquo;s USD 8.9 billion acquisition will allow the combined company to offer care services in more than 680 provider locations in 26 markets. VillageMD&rsquo;s latest acquisition, primary care and specialty care provider 
 <a href="https://sp-edge.com/updates/16968">
 Starling Physicians
 </a>
 , took place in March 2023.&nbsp; Following the acquisition, VillageMD operates more than 700 primary care provider locations.
 
 
 Key customers and partnerships
 
 
 In June 2020, VillageMD and Walgreens announced a collaborative effort to open at least 600 Village Medical centers at Walgreens across more than 30 US markets by 2025. Walgreens invested USD 5.2 billion in VillageMD (from the previously announced USD 1.0 billion), raising its ownership stake to 63% (from 30%). More than half of these practices will be opened in medically underserved communities. As of November 2022, Walgreens and VillageMD operated 150 co-located clinics, and plan to increase this to 200 by the end of 2022.&nbsp;
 
 
 Fundings and Financials
 
 
 In July 2020, the company raised USD 275 million in a corporate round from Kinnevik AB and Walgreens Boots Alliance. VillageMD remains a standalone company and it plans to conduct an initial public offering in 2022. It achieved a revenue of USD 1.3 billion by the end of 2021, increasing from USD 217 million in 2017.
 
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VillageMD

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 Cityblock is a tech-driven primary healthcare provider predominantly targeting less privileged communities (for Medicaid and lower-income Medicare beneficiaries). It offers personalized, around-the-clock primary care and behavioral care in partnership with health insurers and community-based organizations to bring care closer to people in underserved communities.
 
 
 Cityblock&rsquo;s care delivery platform, &ldquo;Commons,&rdquo; connects patients with community health providers and leverages data from various sources such as electronic health records, insurance claims, health information exchanges, pharmacies, and through interactions with the platform for decision support in delivering care. The platform enables care providers to communicate and monitor a patient's progress via its virtual healthcare model.&nbsp;
 
 
 The services of Cityblock are available to members at no additional cost if they are covered by an eligible health plan. As of March 2021, Cityblock catered to more than 70,000 patients. As of August 2021, the company was available in five states on the East Coast.
 
 
 Key Customers and Partnerships
 
 
 In September 2022, Cityblock Health partnered with Indiana-based healthcare company MDwise to open care clinics for its members. Prior to that, the company had partnered with insurance providers such as ConnectiCare (Connecticut), Tufts Health Plan (Massachusetts), Emblem Health (New York), Healthy Blue (North Carolina), Molina Healthcare (Ohio) and CareFirst (Washington DC).&nbsp;
 
 
 Funding and Financials
 
 
 Cityblock is a spin-off of Sidewalk Labs, an Alphabet company that incubates and invests in tech companies and products to improve urban infrastructure. It completed a USD 400 million Series D funding round led by Softbank in September 2021, valuing the company at USD 5.7 billion. The company plans to enhance accessibility to its services, increase its membership base, and expand its geographical presence to North Carolina and Ohio with the funds raised.
 
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Cityblock Health

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 Everside Health Group (formerly known as Paladina Health) offers preventative care for chronic conditions and primary, mental and occupational healthcare treatments for acute conditions. Patients benefit from around-the-clock access to care, same-day or next-day appointments for in-person, and virtual care visits with zero copays. Focusing mainly on the B2B segment, Everside aims to generate around 17% healthcare cost savings in three years and 31% in five years for its corporate members by leveraging a data-driven approach to care coordination. The company charges a per-member-per-month fee from its enterprise clients, which includes self-insured employers and labor unions. The company leverages data from past medical records, predictive analytics, and AI in the delivery of preventative care services.
 
 
 Founded in 2010 under the name Paladina Health, the company was rebranded in November 2020 as Everside Health following a merger between three primary care groups (Paladina, Activate Healthcare, and Healthstat). Everside filed its prospectus with the US Securities and Exchange Commission in July 2021 for its initial public offering (IPO). As of July 2022, the company is yet to be listed on the New York Stock Exchange under the ticker “EVSD.” 
 
 
 Funding and financials
 
 
 The company reported a revenue of USD 113 million in 2020, up 40% YoY, while net loss for the year improved to USD 2.9 million from USD 19.6 million in 2019. The DPC operates more than 375 clinics across 34 states and has served hundreds of thousands patients as of July 2022.
 
 
 The company received its most recent investment in July 2022, amounting to USD 164 million in growth equity funding. The round was led by New Enterprise Associates (NEA). The funds were allocated towards  growing its market presence and exploring opportunities for M&A as well as to enhance and improve its product features. Additionally, the firm planned to expand its coverage of specialty care services aimed at individuals, employers, and union organizations.
 
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Everside Health

To gather large amounts of real-time data for chronic care management, DTx, and patient monitoring

XR used by some startups for chronic pain management

Offers digital means of providing direct primary care, passive remote monitoring, chronic care management, etc.

AI/ML is used in predictive analytics, diagnostics tools, and population management

Offers tailored preventive interventions and treatments to the specific needs and characteristics of each individual

Platforms offer a subscription-based or B2B-sponsored, evidence-based program for managing a specific long-term health condition.

Ayble Health

Preventive Healthcare

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Recent Updates

Ayble Health partners with Mayo Clinic to enhance care of chronic GI patients

Ayble Health has raised USD 4.6 million in a seed fund

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