The BioGenerator, the non-profit venture development organization of BioSTL, facilitates the formation of successful, sustainable bioscience companies in the St. Louis region. It provides start-up bioscience companies with pre-seed and seed investment funds, shared lab space with specialized equipment, and in-depth management support.

BioGenerator

Cultivation Capital is a venture capital firm that manages a family of funds focused on early-stage investing. Most of our initial investments are during a startup’s Seed or Series A phase, and our initial checks range from $500k – $3.5M. Our industries of focus include life sciences and health tech, software and IT, agriculture tech, and geospatial tech.

Cultivation Capital

Arch Grants is a nonprofit organization that accelerates economic development and community revitalization by providing $50,000 equity-free grants and pro bono support services to entrepreneurs who  locate their early-stage businesses in St. Louis. Through its rigorously competitive Global Startup Competition, Arch Grants retains and attracts the most innovative entrepreneurs to the St. Louis region. This program is an aggressive effort to inspire the next generation of employers, civic leaders, and philanthropists for St. Louis.   The industry-agnostic Global Startup Competition is year-round, with grants awarded once in the spring and again in the fall.  Arch Grants funds innovative technologies, products, and services wrapped within scalable business models that have the potential to make a national or international impact.

Arch Grants

Pinpoint Holdings is a diversified communications company providing local and long distance telephone, IPTV, Internet and data center services.

Pinpoint Holdings

Venture capital fund helping entrepreneurs launch exponential organizations generally with an impact or sustainability element. Passionate about creating positive impact at scale for humanity and the planet. Particular interest in human optimization, healthcare, and strategic interest in automotive and manufacturing technology. Specialties: HealthTech, Healthcare, DeepTech, impact, Startups, Early Stage, seed, Series A, VC, Angel investor, AutoTech, ManufacturingTech, Robotics, IoT, AgTech, connecting the dots.

Harmonix Fund

With an in-depth focus on research and exceptional due diligence plus a 30-year track record, VCapital Management Co. identifies early-stage, institutional-quality venture capital opportunities with potential to grow, succeed, and deliver returns to investors. Operational support and active guidance are provided to entrepreneurs for increasing chances for a successful outcome. Of particular interest are technology, medical, and science-related deals where growth potential is greatest. Employing a concierge and flexible service structure for investors, the VCapital team guides professional investment advisors and individuals who seek to add venture capital to diversify portfolios, manage risk, and meet wealth management goals.

VCapital

TechWald Holding is a participation holding company investing in Medical Technologies

TechWald Holding S.p.A.

cultivate(MD) is a unique, medical venture capital fund.

cultivate(MD)

MedVenture Partners invests in seed to early stage projects and start-ups in the life science field focusing mainly on medical devices.

MedVenture Partners

QRM Capital is an investment firm. QRM develops industry-leading risk management principles, practices, and models, and provides clients with the advice, knowledge, and tools necessary to adopt those innovations. Since 1987, QRM has partnered with clients to enhance their ability to measure risk, identify profitable opportunities, and make sound financial decisions.

QRM Capital

SentiAR

SentiAR is digital health, software device company adding a new dimension to clinical practice in interventional procedures. Spun out of Washington University, it develops a 3D visualization platform using real-time holography of the patient's anatomy and catheter location, over the patients, with the goal of providing the clinician and patient a faster, safer delivery of care. SentiAR’s mission is to transform the experience for both patient and clinician in interventional procedures with a 3D augmented reality platform featuring real-time holographic visualization of the patient’s actual anatomy, over the patient. The visualization is fully controllable by the clinician, providing an ergonomic breakthrough for the treatment and analysis of cardiac arrhythmias within an interventional catheter lab environment. SentiAR is developing the platform for eventual FDA submission.

SentiAR, a company spun out of Washington University, is a digital health software company that has created a VR visualization platform for interventional procedures, using real-time holography of the patient's anatomy and catheter location. SentiAR's flagship platform, CommandEP, running on the Microsoft HoloLens, offers physicians a real-time, interactive, 360-degree view of the treatment they're delivering, providing them with a single source of truth during interventional procedures. The platform uses real-time data from catheters and 3D electroanatomic mapping systems to create interactive 3D visuals of a patient’s inner heart surface.

Technologies bringing about a new reality

Extended Reality

cultivate(MD) Capital Funds Portfolio Company SentiAR Announces Second FDA Clearance for CommandEP™ Interface

SentiAR, a company spun out of Washington University, is a digital health software company that has created a VR visualization platform for interventional procedures, using real-time holography of the patient's anatomy and catheter location. SentiAR's flagship platform, CommandEP, running on the Microsoft HoloLens, offers physicians a real-time, interactive, 360-degree view of the treatment they're delivering, providing them with a single source of truth during interventional procedures. The platform uses real-time data from catheters and 3D electroanatomic mapping systems to create interactive 3D visuals of a patient’s inner heart surface.These visuals help physicians visualize surgical procedures and improve localization accuracy by up to 50% within the heart. Other benefits include a significant improvement in communication efficiency, with the company claiming that its technology reduces an average of 1.7 commands per target point to 0.17. The company also notes that it has tested its technology in a variety of clinical trials and peer-reviewed studies.Furthermore, the company received FDA clearance in September 2020, which allowed for SentiAR’s platform to be marketed and sold in the US and made it the first holographic guidance system to be used during an invasive cardiac procedure. In <a href="https://sp-edge.com/updates/22659">October 2023</a>, the company announced its second FDA clearance for its CommandEP interface, compatible with the Magic Leap 2.Funding and financialsIn <a href="https://sp-edge.com/updates/17624">April 2023</a>, SentiAR raised USD 8.5 million in a Series B funding round led by cultivate (MD) Ventures. Funding was earmarked for the expansion of clinical deployments alongside the establishment of new partnerships.

Interplay Learning (Interplay) provides on-demand, interactive, and hands-on simulation learning courses for skilled trades, including HVAC, plumbing, electrical, solar, and facilities maintenance, through VR, mobile, and desktop applications. The learning courses also include simulated walkthrough videos where experts lead users through procedure guides methodically, with knowledge testing features and additional learning material such as wiring diagrams, equations, sample system configs, and charts at the end of each lesson. The platform also enables managers to track user progress.The company operates a subscription-based model with monthly packages for individuals (USD 54) and teams (USD 229), alongside a custom plan for larger organizations.Key customers and partnershipsNotable customers include Tesla and Rheem Manufacturing. Interplay’s customer usage rose by 445% YoY in 2020. As of February 2021, the platform had over 2,000 customers and 110,000 users across the US.Funding and financialsIn its last funding round (February 2021), Interplay raised USD 18 million in Series B funding co-led by S3 Ventures and Owl Ventures, the world’s largest venture capital firm focused on education technology. As part of the deal, Managing Director of Owl Ventures, Ian Chiu, joined Interplay’s board. The funds were raised to expand its offering to new markets and to accelerate its vision to combine immersive learning experiences with a human connection.

Interplay Learning

Switzerland-based WayRay develops holographic AR technology and hardware for the automobile sector. Its technology is used in head-up displays (HUDs) that project images into a driver’s field of vision to assist with navigation. Although its initial focus was on developing HUDs that can be purchased and installed in any vehicle, it has since pivoted to producing embedded HUD systems (i.e., hardware built into vehicles). WayRay’s HUDs are considered to provide a wider field of vision and combine data (location and mapping information) with vision data to generate images by projecting a laser beam through a Picture Generating Unit (PGU) onto a Holographic Optical Element (HOE).&nbsp;In <a href="https://sp-edge.com/updates/18537">May 2023</a>, WayRay announced integration of its AR displays into Tesla Model 3's in Switzerland, with plans to follow shortly afterwards in the US. Previously, in September 2021 the company launched its deep reality system that replaces the traditional car dashboard. In addition, WayRay launched “The Holograktor” dubbed the first “metaverse on wheels”, which can be driven conventionally or using a remote control via a 5G and satellite connection (November 2021).&nbsp;The company’s founder and CEO, Vitaly Ponomarev, identified that its systems are more advanced, backed by more patents, and potentially 20x smaller than comparable devices in the market. WayRay’s HQ in Switzerland also acts as a product design and development hub, while its R&amp;D center and prototyping factory are based in Russia.&nbsp;Key customers and partnershipsThe company is backed by strategic investors such as luxury automaker Porsche, which highlighted the management’s expertise in space engineering, hardware, and software development as key reasons for its investment, Hyundai Motor Co., and Alibaba. It is also notable that these investors, particularly Hyundai, are looking at ways to potentially use WayRay’s technology to offer more services in the future. For instance, Hyundai believed that the technology could be used for smart cities and smart buildings, which are its new areas of interest.WayRay partnered with Karma Automotive, a producer of luxury electric vehicles, in December 2021 to support the implementation of its HUDs into their test fleet. Moreover, it partnered with a leader in designing and manufacturing specialty glass, AGP eGlass, in September 2021 to further proliferate its technology.&nbsp; Funding and financialsIt was reported in April 2021 that the company is considering a public listing at a USD 2 billion valuation via a SPAC, although no further updates on this have been announced as at January 2024.&nbsp;

WayRay

AmazeVR initially focused on developing VR technologies but pivoted to VR concerts in late 2019. The concerts are backed by proprietary 9K cameras and software that automate complex VR concert visual effects that run on more than 100 headsets simultaneously. Users join and hang out with other users as avatars while experiencing VR concerts. It intends to bring VR concerts by major artists to theaters and eventually, homes.AmazeVR rolled out its first commercial VR concert, which will feature 3x Grammy winner Megan Thee Stallion, in 2022. The artist is expected to tour select AMC Theaters across the US. It is also in the final stages of closing deals with its second and third artists. AmazeVR also revealed plans to release weekly content by 2024 in theaters and for at-home viewers.In <a href="https://sp-edge.com/updates/20145">July 2023</a>, AmazeVR launched its official AmazeVR Concerts app, featuring an exclusive VR concert from Swedish pop star, Zara Larsson. The app is available on major VR app stores, and the exclusive Zara Larsson VR concert can be accessed for a year at a launch price of USD 6.99. AmazeVR also produces and monetizes VR content on a subscription basis.As of August 2023, the company was in the process of producing and releasing mixed reality concerts by overlaying virtual elements onto live, real-world video.Funding and financialsThe company’s most recent funding was in <a href="https://sp-edge.com/updates/13338">September 2022</a>, when it raised USD 17 million in a Series B funding round led by Mirae Asset Capital. The fresh funds were allocated to expand partnerships with artists, artist management companies, labels, publishers, and agencies.

AmazeVR

Dispelix, based in Finland, designs and manufactures single-layer, full-color waveguide displays, a thin (about 1mm) transparent element that takes in a projected image and relays it to the eye, using a nanophotonics-based approach catering to AR applications (e.g., smart glasses). It uses laser beam scanning technology to render laser-sharp images with a gamut of color palettes, which are displayed using beam-combiner technology. Its patented and proprietary approach includes diffractive surface relief gratings, which are elements used for high-power laser applications, fabricated on high refractive index glass wafers that enhance field-of-view and image quality.The company had a total of more than 40 granted or pending patent families as of November 2021. Its product line, Dispelix DPX, includes Dispelix DPX - Ohut, Dispelix DPX - Selva, and Dispelix DPX - Sade with a varying degree of field of view, form factor, and weight. According to Co-Founder and CTO Juuso Olkkonen, its displays are the lightest and thinnest in the market.Key customers and partnerships1) Foxconn and Pegatron: to create reference designs for AR glasses based on its Selvä waveguide display (October 2023)&nbsp;2) VividQ: created a “waveguide combiner” which accurately displays variable-depth 3D content in a user’s environment (January 2023)3) ColorChip and Maradin: To further Light Beam Scanning (LBS) solutions for AR glasses (October 2022)4) Jade Bird Displays: To develop multiple reference designs for AR devices (June 2022)5) AAC Technologies: To improve waveguide displays for the AR and MR industry (March 2022)6) OQmented: for the development and commercialization of MEMS-based LBS technology (November 2021)7) Coretronic: To develop a range of AR optical module solutions (December 2020)8) Hoya Corporation: To improve quality of waveguide displays (November 2020)Funding and financialsIn its most recent funding round (November 2021), Dispelix raised USD 33 million in a Series B funding round co-led by Atlantic Bridge, CCB Trust, and Flashpoint with participation from Lifeline Ventures, VTT Ventures, and 3M Ventures. The funds were allocated to product development. It revealed that several OEM customers were slated to integrate its technology into their consumer offerings by 2023.

Dispelix

DigiLens is a developer of holographic waveguides, which is a clear, thin piece of glass or plastic, used for AR devices. In January 2023, the company launched ARGO, an XR smartglass designed for enterprise and industrial use, the first AR device to utilize Qualcomm’s SnapDragon XR2 platform. Other specifications included 6-degrees of freedom (6-DoF) tracking, a 30-degree field-of-view, spatial audio, a 48MP RGB camera, voice and gaze recognition, access to real-time data visualizations, and a 2,500-nits HD display.&nbsp;The company’s first product, the DigiLens Crystal was introduced in 2019, was a thin-film laser-etched photopolymer embedded with microscopic holograms of mirror-like optics. By projecting a micro display to one end of the lens and another set of optics working to guide the light wave toward the eye, this proved to be an ideal piece of hardware for AR devices, which are preferred with as little hardware as possible.&nbsp;It claims that its patented optical platform and photopolymer technology coupled with a holographic copy manufacturing process enable it to produce cheaper and more scalable solutions. In <a href="https://sp-edge.com/updates/17598">April 2023</a>, the company announced the launch of SRG+, a surface relief gratings product that improves upon its waveguide technology.The company generates revenue by licensing its technology across a range of industries including the automobile, enterprise, consumer, avionics, and military sectors. DigiLens also offers a white-label solution for automotive companies whereby it creates holographic waveguides for windshields that could offer in-cabin experiences for drivers.&nbsp;&nbsp; Key customers and partnershipsKey partnerships include that with1) Phantom Technologies: - Phantom Technology: To integrate Phantom's CASSI Spatial AI assistant into the DigiLens ARGO glasses, providing features such as spatial search, a contextual assistant, and task management using voice commands (October 2023)2) Wisear: To integrate its neural interface-powered earphones with the ARGO smart glasses (May 2023)3) Mojo Vision: To utilize Mojo Vision's micro-LED technology to build improved AR glasses (May 2023)4) Taqtile: To integrate the company's ARGO smart glasses with Taqtile's AR work platform, Manifest (May 2023)5) OMNIVISION: To develop new XR product offerings (January 2023)Other partnerships include that with OMNIVISION (January 2023), a leading global developer of semiconductor solutions to develop new XR product offerings. OMNIVISION’s liquid crystal on silicon (LCOS) panels allowed DigiLens to build LCOS/LED projectors optimized for its holographic waveguides. OMNIVISION's core camera technology provides DigiLens' devices with features such as visual odometry and six degrees of freedom.&nbsp;DigiLens also works with Taiwanese licensed waveguide manufacturer Young Optics, Chinese original design manufacturer and electronics supplier Malata, Korean display manufacturer Sekonix, international technology company Continental, Chinese optical elements manufacturer Crystal Optech, and Mitsubishi Chemical.&nbsp;Funding and financialsIn April 2022, DigiLens announced the second close of its Series D funding round (intiial close in November 2021) in which it raised USD 50 million at a valuation of USD 530 million. The funds were allocated for the development of DesignV1, its second-generation product.

DigiLens

Companies developing XR headsets and relevant sub-components (displays, sensors, and processors). Also includes complementary XR hardware (tracking devices, haptic vests, and gloves)

Companies offering engines that enable the development of AR/VR content, also includes companies offering capabilities to capture and create 3D images for immersive environments

Companies offering AR/VR solutions or toolkits for specific industry applications, including VR game developers

Companies offering location-based AR/VR experiences

AR/VR platforms offer remote assistance to field experts and headset manufacturers facilitate virtual work

Some solutions in the "content" segment are offered under a B2B SaaS model

Headsets and content segments provide the building blocks for the metaverse

AR, VR, and MR are the primary enabling technologies for the XR industry

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SentiAR has announced that its CommandEP interface, integrated with Magic Leap 2, has received a second FDA 510K clearance. This interface provides physicians with a real-time 3D holographic interface of a patient's heart anatomy, allowing for more precise cardiac ablation therapy. The system can be worn by doctors, offering hands-free manipulation of patient data during procedures. SentiAR plans to conduct new clinical studies later this year. Analyst QuickTake: SentiAR initially received FDA clearance for its CommandEP platform, accessible via Microsoft’s HoloLens headset in September 2020 , making it the first holographic guidance system to be used during an invasive cardiac procedure. The launch of the platform on the Magic Leap 2 will further democratize access to its HealthTech solutions, with the company having raised USD 8.5 million to expand clinical deployments of its platform in April 2023 .

SentiAR

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