Large-molecule Therapeutics

Targeting complex diseases with complex molecules

Overview

Large-molecule therapeutics are drugs that are composed of complex molecules, typically consisting of proteins, peptides, antibodies, or nucleic acids. These are often larger and more structurally complex than small-molecule drugs.

These therapeutics are designed to target specific biological pathways, receptors, or cells and can be used to treat a range of diseases, including cancer, autoimmune disorders, and genetic disorders. Large-molecule therapeutics are typically administered by injection or infusion and can have a longer half-life in the body than small-molecule drugs.

The production and manufacturing of large-molecule therapeutics can be more complex and challenging than small-molecule drugs due to their larger size, increased complexity, and potential for immunogenicity. However, advances in biotechnology and protein engineering have led to the development of new technologies and platforms that have made large-molecule therapeutics an important and growing class of drugs in modern medicine.

Note: Additional sections (e.g., market sizing, detailed overview, incumbents, etc.) can be provided on request.

Market Mapping


Incumbents
Expansion
Go-to-Market
Minimum Viable Product
Ideation
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Monoclonal antibodies (mAbs)
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Antibody-drug conjugates (ADCs)
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RNA-based therapeutics
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Protein therapeutics
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Peptide-based therapeutics
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NBE-Therapeutics
NBE-Therapeutics
NBE-Therapeutics
NBE-Therapeutics
NBE-Therapeutics

The Disruptors


Funding History

Notable Investors


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Industry scope 

This industry focuses on companies developing large molecule-based treatments, which include the following:
  1. Monoclonal antibodies, which are engineered proteins that can target specific proteins or cells in the body. They are used to treat a range of diseases, including cancer, autoimmune disorders, and infectious diseases 
  2. Protein therapeutics used to replace or supplement proteins that are deficient or malfunctioning in the body, such as insulin to treat diabetes
  3. RNA-based therapeutics used to target specific RNA molecules in the body, either to silence or replace them, such as messenger RNA (mRNA)-based vaccines for preventing infectious diseases such as Covid-19
  4. Antibody-drug conjugates (ADCs) that combine the targeting ability of monoclonal antibodies with the cytotoxic effects of chemotherapy drugs
However, we exclude the following areas when selecting companies for this industry:
  1. Gene Therapies, as it involves the direct manipulation of a patient's genetic material, typically using viruses or other vectors to deliver therapeutic genes to cells in the body. Gene therapies do not involve giving a patient a chemical or biological substance that was created outside of their body. Instead, they aim to change the patient's genetic code to treat disease and are often considered to be a separate category of treatment
  2. Biosimilars, which are very similar to existing approved reference products (i.e., an original biologic drug). These are covered in a separate hub
  3. Precision Medicine treatments that are focused on small-molecule drugs
Currently, we do not actively cover this industry, but we have identified it as a potential industry to add to our coverage. For the list of industries in our coverage, please visit https://sp-edge.com/industries.
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