Optum Ventures

New technologies are opening up mental health services to previously overbooked and underserved populations.

Mental Health Tech

Brightline offers behavioral health solutions for children, teenagers, and their families. The services provided on its digital platform include self-guided content, virtual consultations, behavior therapy, psychiatry evaluations, medication support, and speech-language therapy. Brightline covers treatment for behavioral conditions such as anxiety, depression, ADHD, and disruptive behavior. In April 2022, the company <a href="https://sp-edge.com/updates/9742">launched its virtual solution for autism care </a>designed to assist parents and caregivers with children aged 18 months to 6 years old who are at-risk or diagnosed with autism spectrum disorder.Key customers and partnershipsThe company operates a B2B2C business model, partnering with insurance providers such as Blue Shield of California, Blue Cross Blue Shield Massachusetts, and ComPsych. The company’s services were available to over 12 million covered lives via partnerships with health plans as of September 2024. Also in March 2022, Brightline had 10,000 families using its coaching service across 44 states and employees in 33 companies.In March 2023, the company <a href="https://sp-edge.com/updates/16768">partnered with Evernorth</a>, a subsidiary of Cigna Group, to provide Evernorth employer members with access to virtual behavioral care for children, teenagers, and their families. The services were made available across all 50 states and included services such as therapist-led and psychiatrist-led care, one-on-one coaching, interactive exercises, and educational content.&nbsp;Furthermore, in October 2023, Brightline partnered with the California Department of Healthcare Services to launch BrightLife Kids, a program providing free virtual behavioral healthcare. Also, in July 2024, Brightline partnered with Teladoc Health to offer Brightline's mental healthcare services for children, adolescents, and their families through Teladoc's virtual "front door."

Cortica offers various behavioral therapy options for children who face developmental challenges like autism spectrum disorders, pediatric strokes, and behavior disorders. The therapy options include speech therapy, music therapy, neuromodulation therapy, and nutrition counseling. The treatments are available in-person, at home or online, depending on the child's specific needs.The firm leverages data analytics, an in-house scheduling software platform and clinical decision support tools to provide applied behavioral analysis, medical, counseling and developmental services to children diagnosed with autism.In April 2023, the firm acquired two healthcare organizations, which increased Cortica's total integrated autism centers to 23 with 1,600 providers across seven states in the US. Following the acquisitions, the company was expected to serve more than 10,000 neurodivergent children and their families in 2023.Key customers and partnershipsThe company operates a B2B2C business model, partnering with health insurance companies for value-based payment arrangements.&nbsp;In September 2022, Cortica partnered with Point32Health to provide services to Tufts Health Plan commercial members and MassHealth members in Massachusetts. Cortica has also partnered with CVS Health Ventures, which led a USD 40 million funding round for the company in October 2023. This partnership aimed to improve access to Cortica's services for CVS Health members and their dependents.

Groups Recover Together is an evidence-based opioid addiction treatment platform that provides medication-assisted treatments, such as Suboxone (buprenorphine) to reduce cravings, and weekly group therapy sessions led by a licensed counselor for people at different stages of recovery.&nbsp;The company fully transitioned into a telepsychiatry platform in April 2020 during the Covid-19 pandemic and continued to offer virtual services in addition to its brick-and-mortar network of clinics. The company claims to have a 74% member retention rate after 6 months. Its comprehensive approach includes medication management, counseling, peer support, and assistance with social determinants of health such as housing, employment, and relationships.Key customers and partnershipsIn December 2022, the organization served over 20,000 individuals across its network of 142 offices and digital platform, delivering nearly 72,000 hours of group therapy and conducting almost 12,000 biopsychosocial intake appointments.Groups Recover Together works with various health plans and state Medicaid programs to provide services to their members. The company accepts Medicaid, Medicare, and many commercial insurance plans, including Aetna, Optum, United Healthcare, Humana, Anthem, and Blue Cross Blue Shield.

AbleTo was founded in 2008 by Michael B. Laskoff, who suffered from Attention Deficit Disorder. It offers 8-week virtual therapy programs consisting of digital well-being tools and one-on-one therapy (an initial session with a duration of 60 minutes and weekly follow-up sessions lasting 45 minutes each) with a licensed professional. The company focuses on mental conditions such as stress, anxiety, and depression.The company's programs are designed to help participants manage mental health symptoms, develop coping mechanisms, and improve overall well-being through cognitive behavioral therapy (CBT) techniques. In June 2021, AbleTo launched several new product offerings on its platform including a care navigation tool, an integrated app to access its products, and enhanced features for its Therapy+ programs. The new tools are designed to provide a more customized approach to mental healthcare. The company leverages analytics to identify individuals with unmet behavioral health needs and offers members access to personalized virtual therapy. Furthermore, in March 2023, AbleTo expanded its offerings by introducing Self Care+, an on-demand digital wellness program designed to help build everyday resilience and support emotional and mental health.Since the pandemic started, AbleTo has seen a 25% increase in the number of people using its services.&nbsp;Key customers and partnershipsAs of September 2024, AbleTo's services were available to users across the US through partnerships with health insurance providers and employers, covering over 122 million people across 41 health plans and over 1,500 providers. Some of the participating health plans were Aetna, Blue Cross Blue Shield, UnitedHealthcare, and Kaiser Permanente.In July 2022, Sun Life US announced a partnership with AbleTo to offer mental health support services to Sun Life disability and critical illness members receiving benefits due to a cancer diagnosis.

Alma is an electronic health record (EHR) and practice management platform for mental health providers. The platform enables therapists to manage various aspects of their practice, including insurance billing, scheduling, client referrals, and continuing education. Alma's EHR system allows providers to onboard new clients, document care, create evidence-based treatment plans, and track client progress over time using clinical assessments. In June 2024, Alma expanded its EHR suite by introducing AI-generated progress notes through a partnership with Upheal. This feature aims to reduce therapist burnout by automating the note-taking process, allowing providers to spend more time focusing on client care.Alma’s membership for its practice management tools is a monthly fee of USD 125. The company also provides free matching support to patients that use the platform.&nbsp;In <a href="https://sp-edge.com/updates/12631">August 2022</a>, Alma raised USD 130 million in a Series D round led by Thoma Bravo which valued the company at approximately USD 800 million. As of July 2021, the company also experienced a 13x YoY revenue growth compared to April 2020, while its insurance program grew 30x in the past 18 months.Key customers and partnershipsAs of September 2024, Alma’s network of therapists has grown to more than 21,000 members in all 50 US states.In addition to its partnership with Upheal to integrate AI-generated progress notes into its EHR system, it also partnered with Wiley to offer evidence-based treatment plans as part of its EHR functionality.

Equip Health is a digital eating disorder treatment provider that began its operations with a focus on individuals aged 6 to 24. Equip uses a family-based treatment approach by providing patients and their families a dedicated five-person care team; a therapist, dietitian, physician, peer mentor, and family mentor. Sessions can be booked according to a family’s schedule and need instead of sending the patient away to a residential treatment facility.&nbsp;In September 2023, the company announced the extension of its services to adults. The new program for adults had contracts with more than 15 health plans, including national payers and Medicaid plans. The company plans to use a different approach to treating adults, relying on cognitive behavior-enhanced (CBT-E) therapy while also including loved ones in therapy.Key customers and partnershipsAs of September 2024, the product was available in 50 states, and Equip Health worked with 12 major commercial health insurance providers in the US, including Aetna, Anthem, Cigna, Horizon, Magellan Health, Optum, and United Healthcare.&nbsp;

Redefining hospital care with the comfort of home

Hospital-at-Home

Truepill is a digital health company founded in 2016 that provides pharmacy fulfillment services and technology solutions for healthcare organizations. The company offers a B2B application program interface (API) that enables pharmacy fulfillment, delivery, white label packaging, and product design. Truepill's platform encompasses three core pillars: telehealth, diagnostics, and pharmacy fulfillment. As of October 2021, Truepill had delivered over 20 million prescriptions to 3 million patients across all 50 US states.
The company operates multiple pharmacy fulfillment centers across the US, utilizing automation and robotics to efficiently process prescriptions. Truepill focuses on a small number of high-volume medications, with ten drugs representing 80% of its volume. This concentration allows the company to negotiate costs with pharmaceutical companies and pharmacy benefit managers. Truepill's business model positions it as a behind-the-scenes player, providing infrastructure for other healthcare brands rather than competing directly with traditional pharmacies.
In addition to prescription fulfillment, Truepill offers a virtual pharmacy platform, diagnostics services, and a telehealth network. The company's diagnostics platform provides access to over 3,000 at-home or in-person lab tests through CLIA-certified labs. Truepill's telehealth capabilities can facilitate up to 50,000 virtual doctor visits per week.
In December 2022, Truepill faced allegations from the US Drug Enforcement Administration (DEA) regarding the unlawful dispensing of controlled substances, particularly stimulants used to treat ADHD. The company subsequently paused prescriptions for these medications. In November 2023, Truepill settled with the DEA, accepting responsibility for operating an unregistered online pharmacy and filling prescriptions in violation of federal law.
Truepill experienced significant growth and raised substantial funding, reaching a USD 1.6 billion valuation in October 2021. However, the company faced challenges in 2022, including multiple rounds of layoffs and a shift in focus back to its core pharmacy operations. In August 2023, co-founder Sid Viswanathan stepped down as CEO. In November 2023, Truepill disclosed a data breach affecting 2.3 million individuals, compromising personal and health information.

LetsGetChecked is a healthcare solutions company that provides at-home diagnostic testing kits and virtual care services. Founded in 2015 by Peter Foley, the company offers over 30 different health tests covering areas such as sexual health, women's health, men's health, general wellness, and Covid-19. LetsGetChecked's testing process involves customers ordering a kit online, collecting their sample at home, and mailing it back to CLIA-certified and CAP-accredited laboratories for analysis. Results are typically available within 2-5 days through a secure online portal. The company utilizes biomarkers to analyze health conditions and employs highly accurate testing methods like NAAT PCR and electrochemiluminescence arrays for certain tests. In November 2023, LetsGetChecked achieved a significant milestone when the FDA granted marketing authorization for its Simple 2 Test, the first at-home test for chlamydia and gonorrhea. The company has expanded its services to include telehealth consultations and prescription delivery, aiming to provide a comprehensive healthcare solution. LetsGetChecked operates its own manufacturing facilities and laboratories, allowing for quality control throughout the testing process. As of 2024, the company has delivered over 7 million tests and serves more than 30 markets globally.
Key customers and partnerships
LetsGetChecked has partnered with over 300 corporate customers to provide testing services and biometric screening solutions. The company has also collaborated with major retailers and healthcare providers. In 2023, LetsGetChecked announced a partnership with PatientsLikeMe (PLM), a community health network, to offer PLM members access to testing at discounted prices. Additionally, the company has worked with UnitedHealthcare, Optum, HSA Store, FSA Store, and CVS Pharmacy. LetsGetChecked's services are available nationwide in the US, the UK, and most EU countries, with co-headquarters in Dublin and New York.

Contessa Health operates a risk-based model called Home Recovery Care, which aims to provide inpatient hospital care in patients' homes. The company's approach integrates evidence-based home recovery care models for acute care, post-acute care, and surgical procedures. Contessa Health supports this care delivery model with administrative services and a proprietary health informatics platform. This combination of services allows patients to receive essential elements of hospital-level care in the familiar and comfortable environment of their own homes.

DispatchHealth is a Denver-based healthcare company that provides comprehensive in-home medical care services across the US. Founded in 2013, the company aims to transform healthcare delivery by offering high-acuity care in the comfort of patients' homes. DispatchHealth's services include same-day urgent medical care, hospital alternative care, and recovery care. The company employs teams of emergency medicine and internal medicine trained professionals, including nurse practitioners, physician assistants, and emergency medical technicians, who are equipped with advanced medical tools and technologies to treat a wide range of conditions typically handled in emergency rooms or urgent care centers.
DispatchHealth's care model utilizes a proprietary technology platform that manages various aspects of the in-home care experience, including logistics, onboarding, risk stratification, care coordination, and analytics. This platform enables real-time data insights to improve patient outcomes. The company's services are designed to reduce unnecessary emergency room visits, hospital stays, and readmissions, resulting in significant cost savings for the healthcare system. As of December 2023, DispatchHealth reported treating more than one million patients across more than 30 states, leading to a 58% reduction in emergency room visits, an 8.5% 30-day hospital readmission rate, and nearly USD 1.5 billion in medical cost savings.
Key customers and partnerships
DispatchHealth has established partnerships with various healthcare stakeholders, including health plans, provider groups, health systems, employers, senior living facilities, and home health organizations. In May 2023, the company announced a collaboration with Included Health to enhance virtual-to-in-home care delivery, enabling Included Health's virtual primary care clinicians to coordinate with DispatchHealth's in-home clinical services.
DispatchHealth also formed a partnership with Instacart in January 2024 to address food insecurity among patients. This collaboration allows DispatchHealth's medical professionals to provide digital food stipends, offer medically tailored shopping lists, and send food directly to patients' homes.
In the Spokane area, DispatchHealth partnered with MultiCare Health System in August 2019 to improve healthcare access for at-risk patient populations. The company works with almost all major insurance companies, including Medicare and parts of Medicaid, to reduce the cost of care significantly.

CareBridge is a value-based healthcare company founded in 2018 that provides services to Medicaid and dually eligible patients with physical, intellectual, and developmental disabilities who receive home and community-based services (HCBS). The company offers solutions including 24/7 clinical support, decision support, data aggregation, and electronic visit verification. CareBridge's 24/7 clinical support solution involves deploying tablets to high-risk individuals' homes, allowing patients, family members, and caregivers to contact CareBridge's interdisciplinary clinical team of physicians, nurses, pharmacists, and social workers via video visits at any time. The company also conducts regular assessments to ensure patients have the necessary resources and support to maximize their independence and safety at home. CareBridge's decision support product provides health plan care managers with recommendations on HCBS types and levels to help members achieve greater independence while managing costs. The company's electronic visit verification solution is compliant with the 21st Century Cures Act. As of June 2023, CareBridge served 84,000 HCBS members across 12 states and Washington, DC The company's interventions have been shown to reduce emergency room visits, hospitalizations, and total costs while improving clinical quality and independence. CareBridge takes financial risk for the total cost and quality of care for patients, aiming to ensure individuals receive appropriate services at home to prevent unnecessary hospitalizations and ER visits.
Key customers and partnerships
CareBridge partners with managed Medicaid and DSNP plans, including four of the nation's five largest managed Medicaid plans: Optum Ventures, CVS Ventures, Anthem Inc., and HLM Venture Partners (on behalf of Centene Corp.). These organizations collectively serve nearly 60% of all Americans receiving home and community-based services. CareBridge had expanded its services to approximately 115,000 patients across 13 states and the District of Columbia. The company collaborates with home care and home health companies that utilize CareBridge's electronic visit verification and session-data tools.

More important now than ever, telehealth will long outlast the pandemic that drove its growth.

Telehealth

Buoy Health offers an AI-powered symptom checker to help individuals and patients navigate their health concerns by providing personalized clinical guidance. Buoy's platform assesses users’ symptoms and suggests appropriate care options, ranging from telemedicine to primary care and behavioral health resources. The platform aims to reduce unnecessary healthcare visits by directing users to the right level of care by helping patients connect with healthcare providers covered by their health insurance.The company is able to navigate users based on a variety of symptoms relating to several areas, including back and extremities, chest and breast, digestive and genitals, head and face, behavioral, neurological, skin conditions, sleep, and systemic. Based on the user’s patients, the platform can coordinate care for users with regard to a range of healthcare and healthcare-related offerings, including doctors and providers, lab testing, nutrition and vitamins, pharmacy services, skincare products, supplements, and weight management practices and medication. The platform also has community features as well as curated educational material.Key customers and partnershipsIn <a href="https://www.prnewswire.com/news-releases/buoy-health-selected-as-preferred-partner-in-ai-enhanced-symptom-checker-digital-front-door-category-by-consortium-health-plans-301112518.html">August 2020</a>, the company partnered with Consortium Health Plans to be a preferred partner. Through the partnership, Consortium's Clinical Innovation and Partnerships team began recommending Buoy as the AI-Enhanced Digital Front Door for its member plans for patient evaluations when serving their 25 million national account members.In <a href="https://healthcare-digital.com/technology-and-ai/buoy-health-leveraging-ai-partnership-cvs-health">May 2020</a>, the company partnered with CVS Health subsidiary MinuteClinic to provide users with access to convenient, accessible, and affordable care at any of MinuteClinic’s locations across the US.

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 UK-based Vira Health is a specialized telemedicine company that offers treatment and lifestyle suggestions to help women deal with symptoms of menopause. Its downloadable Stella app can help users control symptoms such as hot flushes and night sweats, bladder problems, difficulty sleeping, menopause-related weight gain, mood changes, anxiety, sex issues, and other symptoms. Users are offered a tailor-made 12-week treatment plan via the app to ease symptoms through cognitive behavioral therapy, pelvic floor exercises, diet, and lifestyle changes. Treatments adhere to National Health Service (NHS) guidelines and come with an assigned coach who helps users to be involved in their treatment plans by setting goals, staying motivated, and adhering to treatment schedules. 
 
 
 
 
 The company operates on a D2C and B2B2C basis, where employers can sign up with the company to offer Stella to their employees. The app operates on a freemium model and is currently available only in the UK and only on the App Store for individuals. For employers, the company can integrate Stella into their employee benefits and have full access to all of the platform&rsquo;s features for a fee that is dependent on the scale of the contracting company. 
 
 
 In November 2022, 
 <a href="https://sp-edge.com/updates/14405">
 the company acquired fellow menopause treatment prescriber Alva
 </a>
 for an undisclosed sum. This acquisition enabled Vira Health to launch a fully-regulated online menopause clinic that can prescribe hormonal therapies and non-hormonal alternatives, in addition to its current services.
 
 
 
 
 Funding and financials
 
 
 The latest funding round for the company was in March 2022, where the company raised USD 12 million in Series A financing, led by Octopus Ventures, to boost its app&rsquo;s functionality by including a telehealth component through which virtual consultations can be arranged and medication can be prescribed. These added features were meant to supplement the existing virtual coaching sessions and symptom tracker currently available on the app. 
 
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Heartbeat is a New York-based startup facilitating reactive cardiac care to proactive care leveraging remote monitoring technologies and telemedicine services. The main offering of Heartbeat Health is “Know Your Rhythm,” which is an at-home program for the detection and treatment of heart arrhythmia.&nbsp;Through its virtual-first cardiac care offering, patients receive Heartbeat’s “Zio XT” patch heart monitor directly to their homes along with instructions on how to wear the device. After the patient wears the sensor for the designated amount of time, they mail it back to Heartbeat Health, where the results are analyzed by cardiologists, who then virtually consult with patients on how to interpret their results and what the patient’s next steps should be and order any necessary follow-up visits or tests required. Based on the results, patients are enrolled in a treatment plan with their progress being tracked along the treatment cycle.&nbsp;Key customers and partnershipsIn <a href="https://www.fiercehealthcare.com/health-tech/medarrive-taps-heartbeat-health-connect-medicaid-members-virtual-cardiology-care#:~:text=and%20high%20cholesterol.-,MedArrive%2C%20a%20care%20management%20platform%20offering%20in%2Dhome%20care%2C,network%20of%20high%2Dquality%20cardiologists.">August 2023</a> Hearbeat Health partnered with in-home and virtual healthcare provider MedArrive to provide in-home cardiac care services. Through this partnership, MedArrive will offer Heartbeat Health’s cardiac services to patients of health plans working with MedArrive, with a special focus given to health plans working with Medicaid beneficiaries.

New York-based Unite Us is a healthcare coordination and community management platform that connects community organizations, healthcare providers, state and local governments, and foundations to screen individuals for co-occurring needs, make electronic referrals, share information, and create and monitor patient care plans.&nbsp;As part of its ongoing mission to help healthcare providers recognize patients with unmet social needs and strengthen community-based partnerships, Unite Us acquired a health data analytics platform, Carrot Health, in <a href="https://uniteus.com/press/carrot-health/">August 2021</a>.Key customers and partnershipsIn <a href="https://www.vhchealth.org/news-publications/press-releases/2023/vhc-health-partners-with-unite-us/">May 2023</a>, the company partnered with the Virginia Hospital Center, a health system providing care services across the Washington Metropolitan Area, to meet unaddressed health needs of patients within the area. Through the partnership, users and patients were connected with community-based resources through Unite Us’ Virginia-based network. Community-based resources that are part of the network included community health centers, free health clinics, and nonprofit organizations.As of <a href="https://www.prnewswire.com/news-releases/over-1000-innovative-customers-partner-with-unite-us-on-a-joint-mission-to-improve-health-in-communities-301990754.html">November 2023</a>, the company had surpassed working with 1,000 organizations and healthcare providers, providing 1 million services on its platform. The company worked with organizations such as Lexington Medical Center, Center for Employment Opportunities, Georgia Department of Veteran Service, Coordinated Behavioral Health Services, and Care Partner Network.

A concentration of wealth and a willingness to adopt age-in-place technologies present new opportunities.

Age Tech

DUOS, a digital health startup, provides a virtual service for the elderly to get assistance in completing their daily tasks (B2C business). The platform connects the elderly with a personal assistant to manage tasks, including assisting them with technology, ordering groceries, transportation, and health-related issues (such as booking vaccine appointments). The service is available to eligible Medicare and Dual Eligible Medicaid members (depending on health plan coverage) and is available across all 50 US states.In <a href="https://sp-edge.com/updates/22555">October 2023</a>, DUOS announced the launch of DUOS+AI platform at the HLTH conference 2023. The platform uses a large language model to recommend services based on the social determinants of health of older adults. DUOS+AI is a conversational interface that triages member needs and matches them with resources. The company claimed that its AI technology can interpret various levels of written literacy and support multiple languages, making it accessible and inclusive.In <a href="https://sp-edge.com/updates/35206">October 2024</a>, DUOS launched Chat 2.0, an AI-powered healthcare platform that helps older adults access healthcare services. The platform builds upon its predecessor Chat 1.0 and integrates Retrieval Augmented Generation (RAG) with member-specific documents.Key customers and partnershipsIn <a href="https://press.humana.com/news/news-details/2024/Humana-and-DUOS-Launch-Groundbreaking-Initiative-Enhancing-Care-for-U.S.-Veteran-Seniors/default.aspx#gsc.tab=0">March 2024</a>, the company partnered with healthcare provider Humana to introduce a program to support Humana's veteran seniors in Louisiana. Through the partnership, veteran seniors with chronic conditions that are part of Humana's Medicare Advantage plan offered in Louisiana receive the option to connect with DUOS to receive benefits and resources to help them meet their health-related needs and goals. The companies noted that the program would run until the end of 2024.&nbsp;

New York-based Vesta Healthcare, formerly known as HT Health is a home-focused digital health platform. The company follows a “Homecareist” model supporting the needs of the elderly at home and providing real-time insights such as vitals to the rest of the care team from insurance providers and doctors to care managers. The company claims its program has proven that 88% of urgent alerts can be managed and resolved at home itself, resulting in a 30% reduction of emergency admission rates.Key customers and partnershipsAs of September 2024, Vesta Healthcare serves more than 50,000 people, offering services from home-based primary care to passive monitoring.In <a href="https://sp-edge.com/updates/36072">November 2024</a>, the company partnered with Medical Guardian, a medical alert device company, to enhance chronic care management and remote patient monitoring for Medicaid and Medicare members. The partnership integrated Medical Guardian's cellular-connected vitals monitoring devices and personal emergency response systems with Vesta Healthcare's 24/7 clinical oversight.&nbsp;In <a href="https://www.businesswire.com/news/home/20231219675802/en/Highland-Valley-Elder-Services-Partners-with-Vesta-Healthcare-a-specialized-virtual-home-based-care-provider-to-Support-Elderly-Home-Residents">December 2023</a>, Vesta Healthcare partnered with Highland Valley Elder Services to support elders with complex needs and chronic conditions, allowing them to remain in their home.&nbsp;

Synapticure is a telehealth provider that offers personalized care for individuals living with neurodegenerative diseases such as Amyotrophic Lateral Sclerosis (ALS), Alzheimer’s, and Parkinson’s disease. Synapticure's services include personalized care plans developed through advanced testing, data analytics, and consultations with neurodegenerative disease specialists. The company’s specialized platform additionally provides caregiver education and support, assists with identifying potential clinical trials to enroll patients in, and assigns a dedicated nurse or social worker for care coordination.Synapticure provides its services across all 50 states and accepts most major health plans including UnitedHealthcare, Medicare, and BlueCross and BlueShield. Key customers and partnershipsIn June 2023, Synapicture partnered with the Michael J. Fox Foundation (MJFF) to advance telehealth care via specialty offerings. Through the partnership, MJFF formed an advisory board of patients diagnosed with Parkinson's Disease and care partners to help identify potential clinical trials for Synapticure patients to join.In April 2024, the company partnered with the ALS Association to improve access and quality of care for ALS patients across the US. Through the partnership, Synapticure's telemedicine platform was made available to members of the ALS Association to supplement in-person visits at certified ALS treatment centers, primarily benefiting those living in remote areas. With Synapticure's asynchronous model offering flexibility in scheduling and monitoring, the partnership further alleviated the burden on ALS patients and their caregivers. Additionally, ALS patients gained access to local and national resources, with a designated ALS Association liaison offering customized support within Synapticure's virtual clinic.Most recently, in August 2024, the company partnered with Pearl Health a value-based care technology company, to support dementia patients through the CMS GUIDE (Guiding an Improved Dementia Experience) program. The partnership aimed to improve the quality of life for dementia patients and caregivers by providing access to specialized neurologists, behavioral health support, and comprehensive caregiver assistance. Pearl Health primary care providers began referring Medicare patients to Synapticure for proactive, value-based dementia care. Through the CMS GUIDE program, patients began receiving fully covered online visits with Synapticure neurologists and approximately 80 hours of respite care services at no additional cost.

Automation in clinical diagnostics to improve speed and accuracy in patient diagnosis and treatment.

Clinical Decision Support Systems

Ultromics is a patient outcomes-focused AI-driven health technology company specializing in precision heart failure detection. The company's flagship product, EchoGo, is an AI platform that transforms the way heart failure is diagnosed using artificial intelligence and cardiac ultrasound. The technology empowers clinicians to make precise, efficient, and accurate assessments of heart failure by leveraging the largest known heart disease outcomes dataset in echocardiography.
The EchoGo platform encompasses several FDA-cleared AI algorithms, including EchoGo Core for detecting coronary artery disease (cleared in 2021), EchoGo Heart Failure for detecting heart failure with preserved ejection fraction (HFpEF) (cleared in November 2022), and EchoGo Amyloidosis for detecting cardiac amyloidosis (received Breakthrough Device Designation in April 2023). These algorithms analyze routine echocardiograms to detect various heart conditions that often go undiagnosed during standard assessments.
EchoGo Heart Failure, in particular, has demonstrated exceptional accuracy, with a sensitivity of 87.8% and specificity of 81.9% in identifying HFpEF patients, outperforming clinical algorithms. The technology received New Technology Add-On Payment (NTAP) from the Centers for Medicare & Medicaid Services in August 2023, facilitating its adoption and reimbursement for Medicare beneficiaries.
Ultromics has collaborated with renowned institutions like Mayo Clinic and NHS England to develop its technology. The company has raised over USD 50 million in capital from investors such as Blue Venture Fund, Optum Ventures, Oxford Science Enterprises, and GV to support continued innovation.

Lumeon is a digital health company that provides a cloud-based Care Orchestration platform designed to automate and streamline the care coordination process for healthcare providers. The platform leverages real-time, bi-directional data integration and applies dynamic clinical intelligence to ensure that patients receive the right care at the right time, every time.
Lumeon's Care Orchestration platform acts as a "care traffic control" center, synchronizing disparate data across the care continuum, orchestrating and automating care pathway activities, and delivering relevant information to care teams and patients. By automating routine tasks and workflows, the platform enables care teams to focus on providing direct patient care, working at the top of their licenses.
The platform integrates with electronic health records (EHRs) and other systems, creating a real-time synthetic patient record to inform care decisions. It visualizes care plans, virtualizes monitoring, and automates routine tasks, ultimately reducing manual intervention and associated costs for providers. The platform can be deployed enterprise-wide and applied across various use cases within a healthcare system.
Key features of Lumeon's Care Orchestration platform include real-time bi-directional data integration with EHRs and other systems, automation of care orchestration tasks and workflows, and the ability to present information through multiple modalities, including within EHRs, native interfaces, web portals, and mobile apps.
Lumeon's platform has been deployed by leading healthcare providers in the US and Europe across more than 2,000 care locations, delivering measurable results in as little as 90 days.

Digital Diagnostics is a healthcare technology company that develops artificial intelligence (AI) systems for disease diagnosis by analyzing medical images. The company's flagship product, LumineticsCore (formerly known as IDx-DR), is an FDA-cleared autonomous AI system designed to detect diabetic retinopathy and diabetic macular edema during a patient encounter without needing a physician to interpret the images. LumineticsCore increases patient access to care by providing diagnostic results at the point-of-care, eliminating the need for an additional appointment for most patients. This enables healthcare providers to close the gap in eye exams for diabetes care by offering a specialty-level diagnostic exam where the patient receives care.
Digital Diagnostics has also developed DermSpot, an AI system for detecting certain types of skin cancer, which is currently for investigational use only. The company aims to create AI diagnostic solutions that improve patient outcomes, increase healthcare productivity, and enhance accessibility and affordability of care. In April 2023, Digital Diagnostics expanded LumineticsCore to Labcorp patient service centers in Alabama.
Key customers and partnerships
In 2022, Digital Diagnostics signed a long-term strategic partnership with Baxter International to help front-line care providers deliver high-quality care and improve outcomes. The company also partnered with ArchWell Health to bring LumineticsCore to ArchWell Health centers across the US.
Additionally, Digital Diagnostics entered into a memorandum of understanding with the Kingdom of Saudi Arabia's Ministry of Investment in 2022 for international expansion.

Membership-based, non-insurance healthcare companies helping maintain a steady state of well being.

Preventive Healthcare

Calibrate is a virtual weight loss management platform focused on chronic conditions such as obesity. It is built on the concept of metabolic reset, offering a one-year virtual program for weight loss via a mobile application. The app allows users to consult with obesity specialists, receive metabolism medication, access educational tools and health coaching to treat conditions such as pre-diabetes. In addition, users can track food intake, energy levels, and weight daily using the Calibrate app.The platform charges an annual subscription charge of USD 199 per month for its 52-week program, which includes a metabolic health assessment and a free kit with a smart scale and blood pressure cuff. Members can also purchase a one-time assessment with a Calibrate physician for USD 249.Calibrate claims to be the first D2C telemedicine startup to prescribe Wegovy, a FDA-approved (June 2021) injection for chronic weight management, and to deliver a holistic metabolic reset program with lifestyle interventions. As a result, Calibrate members have reported an annual weight loss of 15%, exceeding the goal of 10%.Key customers and partnershipsThe company’s services were available in 28 US states (as of May 2024) and had experienced a 51% month-over-month membership growth since June 2020.In February 2024, the company partnered with OptumRx to provide weight loss programs to employers. Furthermore, in February 2022, Calibrate partnered with Withings Health Solutions to integrate connected devices with Calibrate’s program.Funding and financialsIn February 2024, it raised an undisclosed funding from Madryn Asset Management to fund its growth initiatives.

Kaia Health is a digital therapeutics company that provides personalized physical therapy and chronic care management solutions for a range of musculoskeletal (MSK) conditions and chronic obstructive pulmonary disease via a mobile app. The app acts as a digital trainer, by tracking a user’s body movements through their camera (mobile phone) and using proprietary motion analysis technology and computer vision to provide real-time feedback. Kaia, unlike its competitors, uses a purely software-based approach to treating MSK, without the need for additional sensor-based devices.It offers a 12-week pain management program comprising access to unlimited 1-on-1 support from certified health coaches, daily curated physical exercises, relaxation exercises, and knowledge modules. The company has also expanded access to underserved communities, launching a Spanish-language version of its MSK platform in January 2024. Further, in <a href="https://sp-edge.com/updates/29648">May 2024</a>, launched the Balance Program for people aged 65 and above as an extension to its digital musculoskeletal therapy.Key customers and partnershipsAs of May 2024, Kaia Health had enrolled over 560,000 users worldwide as well as around 2,000 enterprise clients, covering 90 million lives. The company’s key corporate clients include Fairway Independent Mortgage Corp., Alstom, and Lafargeholcim. Kaia Health has partnered with several health plans, such as VirginPulse, Harvard Pilgrim Health Care and UnitedHealthcare.In October 2021, the company partnered with Luna, an on-demand physical therapy provider to expand into in-person care.Funding and financialsIn April 2021, Kaia Health concluded a EUR 62 million (USD 75 million) Series C funding round led by an unnamed group of investors, and the funds were used to expand its MSK capabilities and COPD solutions across the US and Europe.

Simplifying healthcare administration with intuitive tech tools

Hospital Management

DocASAP is a company that provides an advanced patient access and engagement platform designed for healthcare providers, including health systems, health plans, and physician groups. Their platform aims to streamline the patient journey by enabling patients to find suitable providers based on their preferences, schedule appointments online round-the-clock without needing to call, communicate with their care team in real-time, receive timely care and billing reminders, check-in digitally before visits, and pay bills online.
DocASAP's solutions empower healthcare organizations to navigate patients to the optimal provider and care setting at the right time throughout their access journey. This approach helps improve outcomes, reduce costs, and enhance the overall patient experience. The company's platform integrates with practice management systems and offers real-time data analytics through DocASAP Insights, which tracks scheduling performance to drive operational improvements.
In December 2021, DocASAP partnered with Holy Cross Health, a non-profit Catholic healthcare system based in Fort Lauderdale, Florida, to expand patient access by implementing their online scheduling platform across various specialties. This integration allowed patients to schedule appointments online 24/7 and provided seamless routing to a call center for scheduling assistance.
In April 2020, DocASAP collaborated with LifeStance Health, a national provider of behavioral healthcare services, to streamline access to telehealth and in-person visits during the Covid-19 pandemic. Their platform's provider search, appointment scheduling, and integration with practice management solutions facilitated patient acquisition and accommodated LifeStance's complex workflows.
Additionally, in January 2019, DocASAP partnered with Florida Orthopaedic Institute, Florida's largest orthopedic group, to provide a new standard of access for their patients. Their platform enabled intelligent patient-provider matching, accurate online scheduling across multiple locations, and integration with the institute's practice management system.

Ambience Healthcare is a platform that assists clinicians in managing the administrative aspects of their work, including patient documentation, operational procedures, and accounting processes. The platform caters to various ambulatory specialties, such as cardiology, oncology, pediatrics, and ENT. Ambience Healthcare's product suite, including AutoScribe, AutoCDI, AutoAVS, AutoRefer, and AutoPrep, is fine-tuned for each specialty’s unique workflows, care models, reimbursement frameworks, and prior authorization requirements. It also integrates with EHR workflows like Epic, Cerner, Athena Health, eClinicalWorks, Elation, and AdvancedMD.&nbsp; Key customers and partnerships As of June 2024, Ambience Healthcare’s disclosed customers included Pediatric Associates and Midi Health. Its partnerships include, GI Alliance (February 2024) to introduce AI documentation tools customized for gastroenterology, Oncology Institute (TOI; August 2023) to develop an AI operating system for oncology care, and Eventus WholeHealth (October 2023) to launch a platform of GenAI tools to support workflows of value-based primary care.

A new industry proving that digital connectivity and mental health can co-exist.

Digital Wellness

RealizedCare is a digital care management company focused on addressing chronic pain and mental health conditions. Formed in <a href="https://www.prnewswire.com/news-releases/behavr-and-fern-health-merge-to-form-realizedcare-launch-digital-care-management-platform-to-unlock-the-value-of-digital-therapeutics-301989779.html">November 2023</a> through the merger of BehaVR and Fern Health, RealizedCare combines digital therapeutics (DTx) technology with traditional wraparound services to deliver personalized care at scale.&nbsp;The company's platform uses immersive digital therapeutics, offering a suite of clinically validated treatments across a spectrum of mental wellness and behavioral conditions, including serious mental illness. RealizedCare's offerings include personalized care plans comprising pain neuroscience education, mindfulness practices, calming experiences, and immersive, gamified, graded exercise and movement. Key customers and partnershipsRealizedCare works with health plans, employers, and value-based providers to identify, assess, and engage members with chronic pain. In November 2023, the company partnered with digital health community <a href="https://www.realizedcare.com/press">PatientsLikeMe</a> to provide peer and community support for its members. In November 2023, <a href="https://www.grunenthal.com/en/press-room/press-releases/2023/realizedcare-merge-of-behavr-and-fern-health">Grünenthal</a>, a global research-based pharmaceutical company, became RealizedCare's largest investor and strategic partner, with the CEO of Grünenthal joining RealizedCare's board of directors.

New data privacy regulations have opened up space for a new wave of compliance-focused startups.

Digital Privacy Tools

Secureframe provides an automated security compliance platform designed to protect businesses and individuals from online threats and vulnerabilities. The platform provides protection against malware, phishing, and other types of cyber attacks while also ensuring that sensitive data remains confidential and secure in compliance with privacy regulations such as the GDPR and CCPA. The platform features real-time threat detection, network security, data protection, and compliance management tools to ensure the confidentiality and integrity of data. The platform provides automated collection of audit evidence, security awareness training, infrastructure monitoring, and additional capabilities.Secureframe has a risk register that continuously monitors and mitigates regulatory, legal, and financial risks. It also provides automated real-time alerts to notify users when there is a critical vulnerability that requires immediate attention. The company also has its own in-house compliance team to help users navigate security and privacy compliance issues. Secureframe’s machine learning streamlines and automates the process of managing and completing requests for proposals (RFPs) and security questionnaires based on past responses.Secureframe integrates with over 200 services, including AWS, Google Cloud, Azure, Github, JAMF, and Okta.The company houses more than 200 employees across the US, Canada, and Europe.Key customers and partnershipsAs of September 2024, the company said it served thousands of companies, including Nasdaq, Remote, Finch, Coda, Smartcar, Generali, Doodle, and Ramp. The company serves customers in the technology, retail, financial services, media, healthcare, manufacturing, government, and professional services sectors.

Long-term demographic changes are finally bringing fertility technologies into focus.

Fertility Tech

<div>
 
 Headquartered in Dublin and New York, LetsGetChecked (LGC) offers more than 100 at-home healthcare test kits for fertility, cholesterol, diabetes, thyroid, and Covid-19, among others. It provides the test results online and offers follow-up care through its telehealth and pharmacy offerings.
 
 
 In the fertility tech space, the company offers two types of finger-prick test kits (a progesterone test and an ovarian reserve test) that allow samples to be gathered at home, later being mailed to the lab for analysis. The progesterone test assesses whether ovulation has occurred, and the ovarian reserve test measures the Anti-Mullerian Hormone (AMH) to indicate the number of a woman’s remaining eggs.
 
 
 LetsGetChecked acquired the health and diagnostics company 
 <a href="https://sp-edge.com/updates/10149">
 BioIQ
 </a>
 in May 2022. BioIQ works with employers and health plans to provide health testing solutions such as lab testing, health screening, and vaccination services. The company operates through a nationwide network of labs and served millions of customers as at the date of acquisition. The acquisition expanded LetsGetChecked’s personalized at-home healthcare testing services including lab analysis, affiliated physician support, and prescription fulfillment to BioIQ’s health plans, employers, consumers, and public health partners.
 
 
 Key customers and partnerships
 
 
 As of September 2022, LetsGetChecked offered more than 100 at-home wellness and chronic condition tests, delivered over 10 million tests, and partnered with more than 300 business customers in the US, UK, and the EU.
 
 
 Funding and financials
 
 
 In June 2021, the company 
 <a href="https://sp-edge.com/updates/3009">
 raised USD 150 million
 </a>
 in Series D funding led by Casdin Capital, reaching unicorn status with a valuation of over USD 1 billion. The funds were utilized to expand internationally and strengthen its telehealth services, pharmacy capabilities, and at-home testing. In September 2022, the company 
 <a href="https://sp-edge.com/updates/12938">
 secured a USD 20 million extension
 </a>
 to its Series D round from Morgan Health, bringing the total funding raised to USD 283 million.
 
 
 The company benefited from the Covid-19 pandemic promoting at-home healthcare and claimed its revenue grew 1,500% YoY owing to the pandemic.
 
</div>

Leveraging personal data for custom-fit diagnosis and treatment

Precision Medicine

Scipher Medicine, a precision immunology company, focuses on matching each patient with their most effective therapy, believing that treatment options should be based on clear scientific data. Utilizing Spectra, a proprietary network medicine platform, Scipher develops tests that reveal a person’s unique molecular disease signature and match it to the most effective therapy, claiming to ensureoptimal treatment from the start. The molecular data generated by their tests also supports the discovery and development of novel, more effective therapeutics. Its first commercially available product, PrismRA, is a blood test developed to identify patients that are unlikely to respond to TNF inhibitor therapies, a commonly used treatment for rheumatoid arthritis (RA), and provide alternative options. The company claims this first-of-its-kind molecular test analyzes 23 biological features to generate insights that can help healthcare providers with RA treatment decisions. The B2B2C company partners with payers, health care providers, and pharmaceutical companies such as UnitedHealth Group, Johnson &amp; Johnson, Ambry Genetics, and Optum.Scipher Medicine’s Spectra AI Platform offers an approach to identifying the biological mechanisms that influence drug response. This insight into disease biology enables Scipher to discover new therapeutic targets, find new uses for existing drugs, and improve patient stratification.

Technologies bringing about a new reality

Extended Reality

RealizedCare is a VR-based mental health startup that focuses on chronic pain management, stress, anxiety disorders, depression, and addiction recovery. The company was formed via the merger of BehaVR and Fern Health in <a href="https://sp-edge.com/updates/24126">November 2023</a>. The company provides VR interventions that are available, without its full care management system, to clinicians for their in-clinic use.Evidence-based VR programs include 1) Mind &amp; Motion, a set of gamified experiences to help improve locomotion; 2) First Resort, a transdiagnostic intervention, which provides cognitive behavioral therapy (CBT) skills and tracked assessments for individuals suffering from stress, anxiety disorders, and depression; 3) gameChange (available exclusively in the UK), which models 3D simulations of café, street, doctor's office, and other environments for individuals with agoraphobia.The company’s pain management solutions, studied in 165 subjects across two completed randomized controlled trials (RCT), showcased a 2.5x greater likelihood of a clinical reduction in disability and 20% improvement in pain catastrophizing.Other services offered include the company’s digital management platform. This assigns patients a pain coach and a personalized care plan, inclusive of pain neuroscience education, mindfulness practices, and other exercises. Members will also have access to PatientsLikeMe's digital health community to provide peer support.Key customers and partnershipsPartnerships focused on the company’s product development efforts include the following:1) gameChange, developed by a multi-partner team led by researchers at the University of Oxford and Oxford Health NHS Foundation Trust2) Mind &amp; Motion developed with notable pain scientist Dr. Adriaan Louw to digitize PNE, an evidence-based curriculum for improving pain coping skills3) The digital care platform, developed in collaboration with scientific advisors and pain experts at Massachusetts General HospitalFunding and financialsIn December 2022 (prior to the merger forming RealizedCare) BehaVR and OxfordVR merged to operate under BehaVR’s brand. The merged entities raised USD 13 million in a Series B funding round co-led by Oxford Science Enterprises and Optum Ventures, along with participation from other venture capital firms. The funds raised were allocated to support the merger of the two entities.The company also received an investment of an undisclosed amount from Accenture, through Accenture Ventures, in December 2022. Following the investment, the company became a part of Accenture Ventures’ Project Spotlight, an investment and engagement platform that connects emerging technology startups with the Global 2000 to fill in strategic innovation gaps.

Enabling the health systems to seamlessly connect, exchange, and interpret shared data

Hospital Interoperability

Diameter Health is a company specializing in clinical data interoperability solutions. It offers an automated, scalable technology platform called Upcycling Data that transforms multi-source and multi-format clinical data into a standardized, enriched, and interoperable longitudinal data asset. Diameter Health's Fusion engine upcycles raw clinical data by normalizing it to industry standard terminologies, reorganizing and deduplicating disparate sources, and leveraging clinical informatics best practices. The resulting Upcycled Data is compliant with national standards, consistent with its original intent, and optimized for broad application and actionable intelligence across various use cases. This technology addresses common challenges that limit data usability and exchange, such as non-conformant codes, details buried in text, and inconsistencies from multiple formats or sources. Diameter Health's solutions enable healthcare organizations to unlock the full potential of clinical data for driving better health outcomes and operational efficiencies.
Key customers and partnerships
Diameter Health partners with national and regional health plans, healthcare technology developers, government entities, insurtech providers, health information exchanges, data aggregators, and health IT vendors across the healthcare ecosystem. In February 2022, Diameter Health announced a partnership with Ciox Health, a leading clinical data retrieval company, to enhance Ciox's data network strategy. Ciox leverages Diameter Health's Fusion engine to deliver actionable insights from medical record data to its customers, including healthcare payers, providers, legal firms, and life insurance companies.

Pushing the envelope in MedTech with emerging technologies

Next-gen Medical Devices

Caresyntax is a healthcare technology company that focuses on making surgery smarter and safer through its data-driven surgery platform. The company's enterprise-grade digital surgery platform utilizes proprietary software and artificial intelligence to analyze large volumes of data from various sources in and around the operating room. This includes video, audio, images, device data, clinical, and operational data. The platform generates actionable insights that can be used by surgical teams during procedures and accessed remotely via a dedicated telehealth link.The Caresyntax platform offers a range of features to improve surgical outcomes and operational efficiency. It provides real-time clinically relevant support tools during surgery, surgical workflow optimization before procedures, and clinical safety modules post-procedure. The platform also generates data analytics and insights for medical device companies, insurers, and other healthcare ecosystem players to drive innovation in healthcare delivery.In terms of operational improvements, Caresyntax has reported significant benefits for hospitals using its platform. These include a 39% increase in operating room scheduling block utilization, a 25% increase in billable minutes, and a 40% decrease in after-hours cases. Financially, hospitals using Caresyntax have reported up to 1.5 more surgeries per day, over USD 300,000 additional revenue per operating room, and more than USD 500 additional savings per operating room case based on better block time utilization.Caresyntax has expanded its offerings to include Risk Management as a Service (RMaaS) in partnership with Relyens, a European insurance and risk management leader. The company also offers Clinical Data as a Service (CDaaS) for industry partners to grow revenue, measure and improve value, and inform product development.Key customers and partnershipsCaresyntax has established partnerships with several notable institutions and companies. The University of Iowa healthcare has partnered with Caresyntax to evaluate and standardize pathways in the operating room. The University of Massachusetts Medical School has collaborated with the company to modernize virtual training and identify safety indicators for clinical settings. In April 2021, the American Board of Surgery selected Caresyntax to provide a platform for its pilot program incorporating video-based assessments into their board certification process.The company has also formed partnerships with international institutions. The University Hospital of Strasbourg in France has used Caresyntax software applications to document orthopedic training, leading to better scores, an optimized learning curve, and improved risk management. Sheba Medical Center, the largest medical center in the Middle East, has a research partnership with Caresyntax measuring oncological surgical data across more than 300 variables to develop algorithms for predicting surgical outcomes.

Threat Prevention Toolchain

Secureframe is a leading provider of security compliance automation software. The company's platform streamlines and automates the process of obtaining and maintaining compliance certifications such as SOC 2, ISO 27001, HIPAA, and PCI DSS. Secureframe integrates with over 100 core services like AWS, Google Cloud, Azure, GitHub, JAMF, and Okta to automatically and continuously collect audit evidence, run security awareness training, monitor infrastructure, and more.
The platform uses AI and machine learning to automate manual compliance tasks like evidence collection, continuous monitoring, policy management, risk assessments, and task management. Secureframe's AI capabilities can generate tailored remediation guidance based on an organization's specific configurations and infrastructure. The company's software also provides automated cloud monitoring, scanning resources daily to identify non-compliant configurations.
Secureframe aims to reduce the time and resources required for companies to achieve and maintain compliance. According to a 2024 survey, 97% of Secureframe users reported reducing time spent on compliance tasks, with 76% reducing that time by at least half. The platform provides a centralized view of compliance status across frameworks, automatically mapping controls between different standards to streamline multi-framework compliance.
Key customers and partnerships
Secureframe has experienced rapid growth, increasing its annual recurring revenue by 10x in 2021 and growing its customer base by 7x that same year. As of February 2022, the company's customer list included Stream, Dooly, Lob, Instabase, Slab, Doodle, AngelList, Ramp, and Coda.
In February 2022, Secureframe announced a USD 56 million Series B funding round led by Accomplice, with participation from Kleiner Perkins, Optum Ventures, Kaiser Permanente, Gradient Ventures, Soma Capital, and others. The company planned to use this funding to expand its product offerings, grow its team, and support larger enterprise customers. As of February 2022, Secureframe had grown its team to over 80 people and planned to double in size during 2022.

Synapticure provides neurodegenerative disease patients with disease specialist and wrap around care, no matter where you live in the US. Founded by patients, we support Dementia, Parkinson's, ALS and more with everyone from on-demand disease-specific neurologists to SLT to 24/7 care coordination and support.

Caresyntax is a digital surgery platform that enables OR teams to predict and improve surgical performance. Its enterprise-grade digital surgery platform delivers insights to improve patient outcomes by using proprietary software and AI to analyze large volumes of video, audio, images, device data, clinical, and operational data in and around the OR. Caresyntax insights help surgeons benchmark and improve their care, hospital administrators use surgical resources more efficiently, medical device companies advance better products, and insurance companies understand risk and devise more tailored policies. The software is used in more than 4,000 operating rooms worldwide, has supported more than 30,000 surgeons, and improved care for more than 2 million patients.

Heartbeat Health is a healthcare technology company that delivers virtual-first cardiovascular disease prevention and management. Through its data-powered platform and clinical services, the company helps patients and at-risk organizations benefit from higher-value care by reducing cardiovascular risk and the likelihood of future adverse events. It offers tools and resources critical to supporting digital care by virtually connect patients with doctors securely and helps in sharing information in real-time, and collaborate on treatment and diet consultation, and helps patients to keep track of their heart health and be in touch with a cardiologist.

Humata Health is an AI-enabled deep clinical integration that creates prior authorizations for payers and providers using AI and automation.

Ambience Healthcare’s mission is to supercharge clinicians with breakthrough generative AI technology. The Ambience AI operating system consists of a synergistic suite of applications, designed to alleviate clinician burnout, improve overall system efficiency, and enable high-quality care. By partnering with Ambience, healthcare systems reduce documentation time by an average of 78%, improve coding integrity, and achieve at least a 5X return on investment.

Nema provides comprehensive trauma care administered by PTSD-trained therapists.

Greater Good Health is a healthcare organization enabling and expanding access to value-based, holistic primary care. Through an innovative Nurse Practitioner-led model, Greater Good Health partners with health plans to build primary care practices in underserved, often rural, communities, and partners with risk-bearing organizations to deploy private-labeled clinical programs that enable the shift to value-based, outcomes-focused care. Greater Good Health's proven care model and clinical programs benefit patients, providers, and payers alike, improving outcomes, reducing costs, and delivering a best-in-class patient experience.

Endear Health is the first technology company built from the ground up for the growing needs of an aging population. Endear acts as the single front door, empowering Medicare eligibles with a platform to easily manage their health and benefits.

Cortica provides diagnoses for autism, ADHD, developmental delays, and developmental differences. They offer in-home, in-clinic, and telehealth services. Their services include gene sequencing, metabolic testing, electroencephalography, nutrition evaluation, medication management, ABA therapy, parent coaching, speech-language therapy, occupational therapy, physical therapy, music therapy, and more.

BehaVR creates digital therapeutics for behavioral health using Virtual Reality.  It focuses on the intersection of behavioral health and chronic disease, building skills of stress resilience, emotional regulation, and self-efficacy, helping people better cope with their conditions, be more adherent to care plans, and improve their overall health.

DispatchHealth is a provider of mobile and virtual healthcare for people of all ages in the comfort of their own homes.  DispatchHealt was founded in 2013 and was formerly known as True North Health Navigation. It aims to create an integrated, convenient, triage, and care delivery solution that extends the capabilities of the patient's care team and provides quality care in the home while decreasing costs. It was founded in 2013 and headquartered in Denver, Colorado.

Alma is a membership-based network for mental health care providers that aims to improve access to high-quality, affordable mental health care. Its platform enables providers to accept insurance and also provides a member directory, client-matching service, scheduling, and billing functions, as well as education, training, and a community for support.

Digital Diagnostics, formerly IDx, is a pioneering AI diagnostics company founded with a mission to transform the quality, accessibility, equity, and affordability of healthcare worldwide through the application of technology in the medical diagnosis and treatment process. Founded by Michael Abramoff, MD, PhD, a fellowship-trained retina specialist, neuroscientist, and computer engineer, Digital Diagnostics developed a patented biomarker-based approach to build an autonomous AI platform that makes clinical decisions without human intervention, removing the diagnostic burden of common diseases from specialists. Digital Diagnostics is paving the way for autonomous AI diagnosis to become the new standard of care, helping to democratize healthcare and close care gaps to improve patient outcomes. By working closely with patient advocacy groups, federal regulators, and other quality of care and ethics-focused stakeholders, Digital Diagnostics is working with the healthcare system to enable the continued adoption of autonomous AI.

Medallion provides a network management platform for the healthcare industry. Its all-in-one licensing, credentialing, and payer enrollment platform gets rid of the logistical headaches that all too often eat up valuable time and energy. The company was founded in 2020 by Derek Lo and is headquartered in San Francisco, California, United States.

CareBridge exists to improve the lives of individuals who live with physical, intellectual, or developmental disabilities and receive home and community-based services. Founded in 2018 by Brad Smith and headquartered in Nashville, Tennessee, CareBridge focuses on providing 24/7 clinical support to patients, their family members, and their paid caregivers while helping to ensure that members receive the services, equipment, and support they need to live at home and remain independent. CareBridge exclusively serves patients on Medicaid or patients dually eligible for Medicare and Medicaid.

By using data, technology, and high quality medical expertise, we aim to deliver an empathetic people-centric healthcare experience that helps people live longer.

DUOS is a technology-enabled service provider connecting Medicare beneficiaries to the resources needed to attain the highest level of health. Our proactive and personalized activation platform engages your membership throughout their health journey, delivering quality health outcomes and improving member satisfaction for our valued partners. Our underlying technology aggregates historically siloed data and resources from across the ecosystem, removing barriers to health literacy and access to care, and facilitating contextual and timely connections with closed loop visibility.

Brightline is a technology-enabled behavioral health home for children and their families. Brightline delivers integrated care through innovative technology, virtual behavioral health services, and a collaborative care team focused on supporting children across developmental stages and their families. The company was founded in 2019 and is based in Palo Alto, California.

Vira is a digital health company focused on improving long-term health for women. We do this by addressing female-specific conditions and improving the collection and use of female data in healthcare.

Flume Health makes self-insured health plans affordable and easy to use. They do this by combining the incredible best customer support that they would never expect from their health plan administrator, along with a new payments technology that allows its members to see the same providers for 20-40% less than traditional network rates. The company was founded in 2018  and is headquartered in New York.

Scipher Medicine develops a healthcare platform designed to determine which drug will work best for each patient. The company is committed to transforming the way providers prescribe drugs, as well as the way manufacturers, develop new drugs. They are building a molecular map of all protein interactions that identifies genomic signatures and links those to disease and predictive treatment outcomes. Using a simple blood sample to analyze RNA, Scipher Medicine can predict if a patient is likely to respond to a targeted therapy before therapy is prescribed. This insight allows patients to start the most effective therapy from day one. For its first commercial product, they have developed PrismRA®, a first-of-its-kind blood test that can predict which patients with rheumatoid arthritis are less likely to respond to TNFi therapies such as Humira® and Enbrel® so that such patients can go on alternative approved drugs.   Scipher Medicine is building the future of patient treatment. Most patients who are prescribed blockbuster therapies today don't respond to treatment, costing the healthcare industry billions in wasted drugs while patients continue to suffer. Scipher's platform identifies which drug will work based on the patient's fundamental disease biology, and not based on symptoms, disease classification, or medical bias. A routine blood test predicts which drug he/she will respond to, with our first product focusing on rheumatoid arthritis, ensuring that the most optimal treatment is prescribed from day one. The molecular data generated by our tests are then used to fuel novel target discovery to address a clear unmet medical need in patients who do not respond to any existing therapy.

Secureframe empowers businesses to build trust with customers by automating information security and compliance. Thousands of fast-growing businesses such as AngelList, Ramp, Remote, and Coda, trust Secureframe to simplify and expedite their compliance journey for global security and privacy standards such as SOC 2, ISO 27001, PCI DSS, HIPAA, GDPR, and more.

Somatus is a healthcare company that partners with health plans, health systems, nephrology, and primary care groups. It provides integrated care for patients with or at risk of developing kidney disease. Somatus' vertically integrated clinical services and technology delay or prevent disease progression, improve quality and care coordination, and increase the use of home dialysis modalities and rates of kidney transplantation. The company is headquartered in McLean, Virginia and is founded by a team of healthcare operators, entrepreneurs, and clinicians who treat kidney disease.

Equip is a virtual program helping families recover from eating disorders at home with comprehensive, gold-standard care created by experts in the field and people in recovery. Equip’s five-person care teams include dieticians, physicians, therapists, and mentors who deliver wrap-around support to provide families progress and lasting recovery. Kristina Saffran and Erin Parks co-founded the company in San Diego, California in 2019.

Future offers one-on-one digital training with fitness coaches, at home, at the gym, or on-the-go. Future pairs its clients with coaches who have trained pro athletes, Hollywood celebrities, and working professionals.

MPulse Mobile specializes in conversational AI and digital engagement solutions for the healthcare industry. The company combines technology, analytics, and industry expertise that helps healthcare organizations activate their customers to adopt healthy behaviors.

Garner Health is a provider of healthcare services used to help employers give their employees a better healthcare experience. The company offers its solution through employers who want to give their employees a better quality healthcare experience and in-turn save on the cost of healthcare because the best doctors end up costing the least money. Garner Health was founded in 2019 and is headquartered in New York.

Holmusk develops a real-world evidence platform in behavioral health and chronic diseases to expand data-driven, evidence-based care for people managing behavioral health conditions. It works by bringing together specialty behavioral health data and Holmusk’s novel analytics platform to deliver evidence-based insight that can be used to make treatment decisions, as well as the commercialization of new drugs.

Calibrate is a digital metabolic health business that provides a virtual program for weight loss. It is creating a new category by improving metabolic health to drive long-term, sustainable weight loss with a program designed by world leaders in obesity and nutrition science. Calibrate combines FDA-approved metabolic medication with a holistic curriculum and 1:1 virtual coaching sessions that drive lasting behavior change.  The company was founded in 2020 and is headquartered in New York.

They are building world-class diagnostic aids to help cardiologists — powered by artificial intelligence. To date, they have developed the world’s most accurate echocardiography software to improve the diagnosis of coronary heart disease by more than 90%.

Rey is a membership-based, on-demand mental health company on a mission to revolutionize mental health and wellness by improving access to personalized services through technology.

LetsGetChecked is an at-home health testing platform that connects customers to regulated laboratory testing to better manage and control one's individual health. LetsGetChecked is making healthcare and diagnostics open and patient-led, empowering people to use technology in a simple yet powerful way. This offers consumers greater control over their individual health.  LetsGetChecked is headquartered in New York, New York, with tests covering general wellness, sexual health, women's health, and men's health, and is available nationwide, as well as in Canada and Europe.

Main Street Health is a provider of value-based, care-focused healthcare services aimed at addressing rural wellness concerns. The company's healthcare services are data-driven, and it provides partner clinics with employees, technology, critical access hospitals, community health centers, and possibilities to flourish in the care delivery model, allowing rural residents to receive the high-quality treatment they need.

Groups Recover Together was founded to make treatment for opioid addiction respectful, accessible, and affordable. We empower our members to regain control of their lives through a proven, evidence-based model of medication-assisted treatment (MAT) with buprenorphine and weekly group therapy.

Founded in 2015, Vim connects data to workflow at health care’s “last mile”: within clinical operations at the point of patient care. Health plans, patients, and medical providers of every size – from independent practitioners to integrated delivery systems – use Vim software to connect data and care across the health system. Vim’s mission is to power affordable, high quality health care through seamless connectivity. For more information, please visit getvim.com.

Kaia Health is a digital therapeutics company that creates evidence-based treatments for a range of disorders including back pain and COPD. Working with experts in various medical fields, the company uses machine learning to deliver individualized app interventions that aim to empower and motivate patients to take control and self-manage their condition with digital alternatives from their home using devices they already own (i.e. smartphones and tablets). The company has enrolled more than 400,000 users to date in its digital therapy program. It was founded in 2016 and is headquartered in Brooklyn, New York.

Vesta Healthcare is an industry-leading technology and clinical services organization, dedicated to connecting caregiver insights to the rest of the care team. Vesta Healthcare proactively identifies the need for additional resources in the home and provides 24/7 telehealth support for caregivers and care recipients, with a focus on high-need, frail senior populations. Vesta partners with home care agencies, health plans and providers to create value-based population health programs that emphasize clinical quality, improved health outcomes and personalized engagement. Vesta Healthcare is headquartered in New York, NY.

Unite Us is a veteran-led technology company that builds coordinated care networks connecting health and social service providers together. The company helps systems and communities efficiently deliver care and services by inter-connecting providers across communities, seamlessly integrating the social determinants of health into patient care. Providers across the continuum and community are able to externally refer and track every patient’s total health journey while reporting on all tangible outcomes across a full range of services in a centralized, cohesive, and collaborative ecosystem. This social infrastructure helps communities move beyond legacy resource directories, and transform their ability to measure impact, improved health, and outcomes at scale. The company was founded in 2013 by military veterans Dan Brillman and Taylor Justice in New York, New York.

PatientsLikeMe is a personalized health network of an integrated community, health management, and real-world data platform. It helps people find new options for treatments, connect with others, and take action to improve their outcomes. The company has worked with every major pharmaceutical company and a range of government organizations to bring the patient voice to research, development, and public policy. With more than 600,000 members, PatientsLikeMe is a trusted source for real-world disease information and a clinically robust resource that has published more than 100 research studies. The Boston, Massachusetts-located company was founded by Ben Heywood, James Heywood, and Jeff Cole in 2004

Sitka is a customizable video software platform that connects primary care providers to the virtual specialty provider network. By upskilling primary care providers, collapsing the care cycle, and enabling patient inclusion, Sitka is transforming specialty care in the US. Founded by healthcare experts in medicine, technology, policy, and product, Sitka’s mission is to foster informed, effective and trusted care delivery for all patients by every provider. The company is backed by investors including Venrock, Optum Ventures, First Round, Rock Health, Homebrew, Lifeforce Capital, and Box Group. It was established in San Francisco, California in 2018 by Kelsey Mellard, Shaun Lindsay, and Sohrab Gollogly.

Diameter Health transforms patient information into the quantity and quality of interoperable data for healthcare organizations.  The core of the Diameter Health platform is Fusion, which enables intelligent data exchange ingestion and cleansing through sophisticated normalization and cleansing processes. Data originating from any certified Electronic Health Record (EHR) is transformed into clinical information optimized for use at the point of care or to be consumed as a rich substrate for analytics.

Springtide Child Development offers personalized, holistic treatment plans for children 2-18 years old with autism and other developmental difficulties. Our interdisciplinary team of caring specialists coordinates daily to track progress and help your child succeed.

Buoy provides a personalized all-in-one platform to help guide consumers back to health. Whether it's chatting about symptoms with Buoy Assistant to get help in the moment of sickness or researching benefits through Buoy Dashboard, Buoy is available 24/7 to help make self-diagnosis and navigating the healthcare system simple and easy. For employers, Buoy can be custom configured to surface benefits information and wellness programs, guide employees to in-network providers, and fully integrate with other health portals.  The company was founded in 2014 and is headquartered in Boston, Massachusetts.

Truepill is a B2B pharmacy fulfillment service. They provide a pharmacy API and fulfillment of medications to 50 states from their own facilities. They work directly with D2C consumer brands (e.g. Hims, Nurx), digital health companies, and other healthcare organizations. They are a team of 150 employees and have raised funding from Initialized Capital, Y Combinator, Slow Ventures, Sound Ventures, Tuesday Capital, Foundation Capital, Index Ventures, Social Capital, Box Group, Joe Montana, and others. Founded in 2016 by Umar Afridi and Sid Viswanathan, Truepill is headquartered in San Mateo, California.

Lumeon is a digital health company that has defined the market for Care Pathway Management (CPM). From scheduling and revenue management to clinical reporting and aftercare, by looking across the end-to end care pathway, Lumeon addresses the system, and not just the symptom, behind healthcare transformation. Lumeon's customers number among Europe’s fastest growing and most innovative healthcare providers including BUPA, Nuffield Health, Alliance Medical, HCA, Optegra and Newmedica. It is headquartered in London employing over 90 people.

DocASAP is a hospital and healthcare company that provides patient access and engagement platform for health systems, payors, and physician groups. DocASAP builds unique payer-provider connections with an eye towards simplified access, increased care compliance, and improved population risk management. DocASAP's intelligent patient-provider matching enables patients to connect with optimal care providers to enhance access, improve outcomes and reduce costs.'s  The company was founded in 2012 and headquartered in Virginia, United States.

Mindstrong is a virtual mental health platform that combines care, data and technology to help members do better, feel better & stay better. They offer mental health care with the strength to tackle anything and have helped thousands of members grow and improve their mental health— including those with serious mental illness.

RubiconMD is a web-based eConsult service that enables primary care providers to quickly and easily discuss their cases with top specialists, so they can provide better care—improving the patient experience and reducing costs. RubiconMD was founded in 2013 by Gil Addo, Carlos Reines, and Julien Pham. It is headquartered in New York, New York.

Oxford VR is a spin-out from Oxford University built on the work of Professor Daniel Freeman who has been developing effective VR-based mental health treatments for 15 years. Ground-breaking research, combined with the advent of highly immersive consumer VR, means that they can provide millions of treatments that are: faster and more effective than traditional treatments; significantly lower cost to health providers; loved by users. Their focus is on developing clinically validated, cost-effective, user-centered treatments for clinical conditions with significant impact on patients, the health system, and the wider economy.

Based in Nashville, Contessa is the leader and pioneer of Home Recovery Care, a risk-based model that combines all the essential elements of inpatient hospital care in the comfort of patients’ homes.  Founded in 2015, Contessa utilizes a cutting-edge proprietary health informatics platform to facilitate Home Recovery Care that is safe, affordable and improves patient outcomes. Contessa’s turnkey solution provides upfront savings to health plans, enables health systems to reinvent their care delivery model by treating patients without admitting them into the hospital, and helps physicians deliver a better experience for patients. For more information, visit contessahealth.com or follow us at @contessahealth.

With wasteful healthcare spending in the U.S. estimated at $935 billion, we take our role as a healthcare innovator very seriously. Simply put, we’re on a mission to transform quality measurement and care delivery. To drive toward a Learning Health System—a framework that drives better outcomes and cost efficiencies across the health ecosystem—the industry has to commit to real change. Apervita is that change. Through our solutions and trusted collaboration platform, we’re committed to making the Learning Health System a reality, making healthcare smarter and ultimately improving patient care. As we move into our next phase of growth, we’re looking for passionate and fearless professionals to help us pursue our mission. We’ve earned the trust of our investors, including Optum Ventures, Baird Capital, Pritzker Group Venture Capital and Math Venture Partners, to further grow and scale our business. We’ve also been recognized as an industry leader by Gartner, CIOReview, Healthcare Tech Outlook, and Healthcare Informatics. Always in search of the next “first,” Apervita was named the first company to certify electronic clinical quality measures from the National Committee for Quality Assurance (NCQA) using our proprietary clinical quality language (CQL) ingestion engine. And, we were recently awarded by Healthcare Innovation for our innovative work with The Joint Commission, one of the nation’s largest regulatory organizations. We believe we’re making a difference every day to drive improvements in quality care that lead to better patient outcomes with a lower cost of care. We’re honored to be on this incredibly important journey to build a better healthcare system.

icometrix provides clinicians with standardized measurements on their patients’ brain MRI scans in order to improve personalized care of people with a neurological disorder.  icometrix was founded in 2011 by Dirk Loeckx and Wim Van Hecke. It is a spin-off company of the universities and university hospitals of Leuven and Antwerp. Today, icometrix has grown to a team of over 25 people and is internationally active, with headquarters in Leuven and an office in Boston, USA. They are the worldwide standard in MRI biomarkers in routine clinical practice.  icometrix developed MSmetrix, which detects brain lesions, calculates lesion volume and measures the whole brain and grey matter volume and atrophy. MSmetrix, received market approval in the EU and other countries including Canada, Brazil and Australia. FDA clearance is pending. Furthermore, icometrix is ISO9001 and ISO13485 (Medical Devices) and ISO27001 (Information Security) certified.  icometrix also acts as an image analysis expert in clinical trials and research studies. Imaging biomarkers constantly lead to new insights on neurological disorders. Since recently, imaging biomarker outcomes often serve as the primary endpoints in clinical trials for the development of new drugs. For these purposes large batches of brain imaging data are frequently transferred to icometrix for fast and high quality processing. This way our software-as-a-service is incorporated in clinical trials and large research studies regarding Traumatic Brain Injury (TBI), Epilepsy, Alzheimer’s Disease, Stroke, etc.

AbleTo is a leading provider of virtual behavioral health care. Deep behavioral health insights and an integrated proprietary platform identifies and engages the right patients with the right support – when and how they want it. Their proven programs improve clinical outcomes and lower health care costs. AbleTo is committed to reach people with unmet behavioral health needs and eliminate barriers through virtual care. Their high-quality behavioral health care delivers results for their patients and their clients. AbleTo is proven to improve health outcomes and reduce medical costs with a program that earns high satisfaction scores from patients.

SHYFT is an integral part of the life sciences ecosystem and as the market undergoes a dramatic transformation to deliver more personalized and value-based medicine, the role of SHYFT has never been more important. The SHYFT Platform helps life science companies integrate clinical and commercial data and translate it into patient-centric intelligence and analytics for use across functional groups, shortening development cycles and commercialization activities while improving the probability of success.

Optum Ventures provides capital and strategic guidance to startup companies solving health care's pressing challenges. It is the venture capital investment arm of Optum that invests in digital health companies that use data and insights to help improve consumers' access to health care services and how care is delivered and paid for, and that makes the health care system more reliable and easier to navigate.

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